Protein Alignment cDIP and NRROS

DIOPT Version :9

• Sequence 1: NP_650951.1
• Gene: cDIP / 42512
• FlyBaseID: FBgn0038865
• Length: 554
• Species: Drosophila melanogaster
• Sequence 2: NP_940967.1
• Gene: NRROS / 375387
• HGNCID: 24613
• Length: 692
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 107/451 - (23%)
• Similarity: 171/451 - (37%)
• Gaps: 118/451 - (26%)

  Fly    34 SGSSRIVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLPTEVRIAEDGTTYEVGDEEHSRTL 98
            ||::    .::.:|.|:..|....|||...|        .:|:.:             ..|:|.|
Human    23 SGTA----TAASQGVCKLVGGAADCRGQSLA--------SVPSSL-------------PPHARML 62

  Fly    99 IFEN---CTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKT 160
            ..:.   .|..|..|:.:..||  .|.:..|                         |:|.:....
Human    63 TLDANPLKTLWNHSLQPYPLLE--SLSLHSC-------------------------HLERISRGA 100

  Fly   161 FRGAGNLEFIFLNRNKLG---KLQAGAFDNLLKLQYLDLTENRL-EALAADVFAGLKSLRHVGLA 221
            |:..|:|..:.|..|.|.   :..|.|...|..|:.|||:.|.| |.:||.:...|.|||.|.||
Human   101 FQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLA 165

  Fly   222 GNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLS-NNPELVVLLLNIN 285
            ||.:..::..:|.....|..:.:|.|.:.|:...||....   ::::::|: ||...:|   :..
Human   166 GNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLA---ELRHLNLAFNNLPCIV---DFG 224

  Fly   286 ATNLTARNCSLDRVNLY--------GSVTNVDLSDNRVRELYF---PASEALEHLVLRNN----- 334
            .|.|...|.|.:.:..:        ..:..:|||.|::  |:|   |....|..|:||:|
Human   225 LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL--LFFPLLPQYSKLRTLLLRDNNMGFY 287

  Fly   335 -----------------------------SLVQLASLSRVPRLRHLDVADNPNLGQLPDGW--RT 368
                                         ||.:..|.|.:..||.||::.| ....||||:  :.
Human   288 RDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQN-QFQYLPDGFLRKM 351

  Fly   369 PHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEID--PSAFPTLTQLTHFYIHGN 427
            |.|..|.|.....|.|.:...:....|.:||:|.|.|:|:.  |.....|..|..|.:..|
Human   352 PSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSN 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	2/23 (9%)
		LRR_RI	143..407	CDD:238064	81/315 (26%)
		leucine-rich repeat	143..166	CDD:275380	3/22 (14%)
		LRR_8	166..225	CDD:290566	25/62 (40%)
		leucine-rich repeat	167..190	CDD:275380	7/25 (28%)
		leucine-rich repeat	191..214	CDD:275380	10/23 (43%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..265	CDD:275380	6/25 (24%)
		leucine-rich repeat	266..325	CDD:275380	15/70 (21%)
		LRR_8	304..357	CDD:290566	20/89 (22%)
		leucine-rich repeat	326..347	CDD:275380	9/54 (17%)
		leucine-rich repeat	348..394	CDD:275380	15/47 (32%)
		LRR_8	369..428	CDD:290566	18/61 (30%)
		LRR_4	393..433	CDD:289563	12/37 (32%)
		leucine-rich repeat	395..418	CDD:275380	9/24 (38%)
NRROS	NP_940967.1	leucine-rich repeat	42..61	CDD:275380	6/39 (15%)
		LRR 1. /evidence=ECO:0000255	58..79		6/20 (30%)
		leucine-rich repeat	62..82	CDD:275380	4/19 (21%)
		LRR_RI	76..>285	CDD:238064	61/243 (25%)
		LRR_8	81..144	CDD:290566	20/89 (22%)
		LRR 2. /evidence=ECO:0000255	82..103		7/47 (15%)
		leucine-rich repeat	83..106	CDD:275380	7/49 (14%)
		LRR 3. /evidence=ECO:0000255	106..127		5/20 (25%)
		leucine-rich repeat	107..133	CDD:275380	7/25 (28%)
		LRR 4. /evidence=ECO:0000255	133..155		9/21 (43%)
		leucine-rich repeat	134..158	CDD:275380	10/23 (43%)
		LRR_8	157..217	CDD:290566	17/62 (27%)
		LRR 5. /evidence=ECO:0000255	158..179		9/20 (45%)
		leucine-rich repeat	159..182	CDD:275380	8/22 (36%)
		LRR 6. /evidence=ECO:0000255	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	6/25 (24%)
		LRR 7. /evidence=ECO:0000255	206..227		4/23 (17%)
		leucine-rich repeat	207..227	CDD:275380	4/22 (18%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		LRR 8. /evidence=ECO:0000255	228..239		3/10 (30%)
		LRR 9. /evidence=ECO:0000255	251..272		7/22 (32%)
		leucine-rich repeat	252..273	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	273..294		5/20 (25%)
		LRR 11. /evidence=ECO:0000255	329..350		9/21 (43%)
		LRR_8	330..388	CDD:290566	20/58 (34%)
		leucine-rich repeat	330..353	CDD:275380	9/23 (39%)
		LRR 12. /evidence=ECO:0000255	353..374		5/20 (25%)
		leucine-rich repeat	354..377	CDD:275380	5/22 (23%)
		LRR_RI	357..594	CDD:238064	16/56 (29%)
		LRR 13. /evidence=ECO:0000255	377..398		8/20 (40%)
		LRR_8	378..438	CDD:290566	12/35 (34%)
		leucine-rich repeat	378..403	CDD:275380	9/24 (38%)
		LRR 14. /evidence=ECO:0000255	403..424		3/10 (30%)
		leucine-rich repeat	404..427	CDD:275380	3/9 (33%)
		LRR 15. /evidence=ECO:0000255	427..447
		leucine-rich repeat	428..463	CDD:275380
		LRR 16. /evidence=ECO:0000255	463..484
		leucine-rich repeat	464..486	CDD:275380
		LRR 17. /evidence=ECO:0000255	486..507
		leucine-rich repeat	487..512	CDD:275380
		LRR 18. /evidence=ECO:0000255	512..534
		LRR_8	513..570	CDD:290566
		leucine-rich repeat	513..537	CDD:275380
		LRR 19. /evidence=ECO:0000255	537..558
		leucine-rich repeat	538..559	CDD:275380
		LRR 20. /evidence=ECO:0000255	559..580
		LRR 21. /evidence=ECO:0000255	585..594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100