DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and Toll-4

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	122/594 - (20%)
Similarity:	215/594 - (36%)	Gaps:	194/594 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DLPTEVRIAEDGTTYEVGDEEHSRTLIFENCTFTNFPLRLF-----YTLEVSELDMRGCGIRFIY 132
            |...:::..|..|..|:  .|.|:...|:|  ||.|....:     :||.::|:   .|.::.
  Fly   321 DNMVDLKSFEKFTNLEI--IEVSQYKGFKN--FTAFICEPYKSHCKFTLGINEV---ACPLKC-- 376

  Fly   133 WENFSIGADKLVI------------------------LLLSDNHIEVLPTKTFRGAGNLEFIFLN 173
              |.|...||..:                        |:...|.:..||..:..|..||:.:.::
  Fly   377 --NCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVS 439

  Fly   174 RNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTI-----ESDLF 233
            .|:|..|.......  .|.|||:..|::..|:..|...|.|:......||:.:..     ..:.|
  Fly   440 YNQLTSLSVSQLPE--SLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFF 502

  Fly   234 AHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNNPELV--VLLLNINATNLTARNCSL 296
            .:...||.:  :.::.:.:             |:|::||:....|  ..:.||:...|.|....:
  Fly   503 WYKAKLLRI--KTSKFQTI-------------MEYIELSSKGSFVENFFVQNIDQLYLEANEDEI 552

  Fly   297 DRVNLYGSVTNVDLSDNRVRELYF--PASEALEH-----------LVLRN-NS------------ 335
              ::.:|.      ||.     ||  ...|||.|           ::|.: ||
  Fly   553 --IDAFGP------SDK-----YFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEW 604

  Fly   336 -----LVQLASLSR--VPRL---------RHLD--------------VADNPNLGQLPDGWRTPH 370
                 |:...:||.  .|||         .:||              ||.:.::.:|       |
  Fly   605 HTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKL-------H 662

  Fly   371 LEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTL---TQLTHFYIHGNNWNC- 431
            :...:||     ||||..|.  :|:..||:..|.|..:|......|   ..:|...:.||.|.|
  Fly   663 MSQNLLR-----ELPLHLLP--ENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECN 720

  Fly   432 FSLRNIMDVLIRANGIAY-----TVDNYDPDFPGEYFHGIACMYRLPEKEGVDSSSSSEISASVE 491
            ...:..:..|.|...:.|     .|:..|...|.:.   |.|         ||:|:|..::..|:
  Fly   721 CKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDC---ICC---------VDTSNSDSLAYVVD 773

  Fly   492 SSPITSSSDPSEVDKL-------------RDELK----AVVQHFDS--KFDLIFSKLA---QLNE 534
                .|..:.||:.:|             |:.||    :::..:.|  :|.|..::|:   ||.:
  Fly   774 ----CSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPD 834

  Fly   535 QIQAFEVLN 543
            :::..::.|
  Fly   835 KLEYLDISN 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	4/23 (17%)
		LRR_RI	143..407	CDD:238064	69/350 (20%)
		leucine-rich repeat	143..166	CDD:275380	5/46 (11%)
		LRR_8	166..225	CDD:290566	16/58 (28%)
		leucine-rich repeat	167..190	CDD:275380	4/22 (18%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..238	CDD:275380	3/27 (11%)
		leucine-rich repeat	239..265	CDD:275380	2/25 (8%)
		leucine-rich repeat	266..325	CDD:275380	14/62 (23%)
		LRR_8	304..357	CDD:290566	21/108 (19%)
		leucine-rich repeat	326..347	CDD:275380	8/51 (16%)
		leucine-rich repeat	348..394	CDD:275380	14/68 (21%)
		LRR_8	369..428	CDD:290566	17/61 (28%)
		LRR_4	393..433	CDD:289563	12/43 (28%)
		leucine-rich repeat	395..418	CDD:275380	6/25 (24%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380	2/12 (17%)
		leucine-rich repeat	335..386	CDD:275380	16/61 (26%)
		leucine-rich repeat	388..408	CDD:275380	0/19 (0%)
		LRR_8	412..465	CDD:290566	15/54 (28%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	11/39 (28%)
		leucine-rich repeat	433..454	CDD:275378	4/22 (18%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	9/34 (26%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380	5/23 (22%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	5/18 (28%)
		leucine-rich repeat	836..859	CDD:275378	1/8 (13%)
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930