Protein Alignment cDIP and CG42346

DIOPT Version :10

• Sequence 1: NP_650951.1
• Gene: cDIP / 42512
• FlyBaseID: FBgn0038865
• Length: 554
• Species: Drosophila melanogaster
• Sequence 2: NP_001036303.2
• Gene: CG42346 / 3355160
• FlyBaseID: FBgn0259677
• Length: 1817
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 144/607 - (23%)
• Similarity: 239/607 - (39%)
• Gaps: 141/607 - (23%)

  Fly    29 DADVDSGSSRIVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLP--TEVRIAEDGTTYEVGD 91
            |..|...:.|:..|.....|..|.|.|.|               :||  .||.::|:.......|
  Fly   524 DPKVFEKNKRLQTVDLSHNHIHTIGGVFS---------------NLPQLREVFLSENNILELPAD 573

  Fly    92 EEHSRT----LIFENCTFTNFPLRLFYTL-EVSELDMRGCGIRFIYWENFSIGADKLVILLLSDN 151
            ...:.|    :..|:....:....:|.|| .:..|.:|...|..:....|. .:.||..|.|.:|
  Fly   574 AFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFD-KSTKLTSLSLDNN 637

  Fly   152 HIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLR 216
            .|:.|....||...:|..:.|:.|::.:::.|.|:.|..||.|.:.:|.:|.:....|..|::::
  Fly   638 EIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQ 702

  Fly   217 HVGLAGNQLTTIESDLFA-HNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN------ 274
            |:.|..||||.:| |:|. .|..||||.::.|.|.:|....|   .|..::|.:.|.:|
  Fly   703 HINLQDNQLTVLE-DIFPDENSSLLSVQLEANYLHKVHPRTF---SRQQKVQIMWLKDNQLTRVE 763

  Fly   275 -------PELVVLLLNINATNLTARNCSLDR-VNLYGSVTNVDLSDNRVREL---YFPASEALEH 328
                   |:|..|.|:.|    ..|:...|. |||. .:..:|||.|::|:|   ||...:.||.
  Fly   764 RSFFADTPQLGRLYLSDN----KIRDIEKDTFVNLL-LLQFLDLSGNQLRQLRRDYFAPLQDLEE 823

  Fly   329 LVLRNNSL--VQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPH-LEMLVLRNTGQMELPLEALQ 390
            |.|..|.:  ::..:.:::..|:.||::.||.:....|.:.... |..|.|.|....:|...|.:
  Fly   824 LSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFK 888

  Fly   391 GMQNLQKLDISGNNLTEIDPSAFPTL--TQLTHFYIHGNNW------------------------ 429
            .:.||.:|::..|   :::|:...||  ..|....:..||:
  Fly   889 SLTNLNELNLERN---QLNPADIQTLDIPNLRRLLLSHNNFSYAGSVGIMAGMLDRLRSLQQLSM 950

  Fly   430 -NCFSLRNIMDVLIRANGIAYTVDNYD---------------------------PDFPGEYFHGI 466
             || ||..|.|:|...|.....:|..|                           .|||    |
  Fly   951 SNC-SLGQIPDLLFAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFP----H-- 1008

  Fly   467 ACMYRLPEKEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFSKLAQ 531
            ..:|.|...|.:|.:.:.  .||::...::.:.:..:: .|||                 :|:..
  Fly  1009 IALYNLSTLESLDLARNQ--LASIDFFKLSGTLNLRQL-ILRD-----------------NKITA 1053

  Fly   532 LNEQIQAFEVLNKTVWSQVTLS 553
            |:    .|..:|.|....|.||
  Fly  1054 LS----GFNAVNLTQLDSVDLS 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	LRR	107..>410	CDD:443914	90/324 (28%)
		leucine-rich repeat	118..142	CDD:275380	4/23 (17%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	10/23 (43%)
		leucine-rich repeat	239..265	CDD:275380	9/25 (36%)
		leucine-rich repeat	266..325	CDD:275380	21/75 (28%)
		leucine-rich repeat	326..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..394	CDD:275380	12/46 (26%)
		leucine-rich repeat	395..418	CDD:275380	6/24 (25%)
CG42346	NP_001036303.2	LRR	<301..606	CDD:443914	20/96 (21%)
		leucine-rich repeat	303..325	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR	486..>736	CDD:443914	61/228 (27%)
		leucine-rich repeat	486..509	CDD:275380
		leucine-rich repeat	510..533	CDD:275380	2/8 (25%)
		leucine-rich repeat	534..556	CDD:275380	7/36 (19%)
		leucine-rich repeat	557..580	CDD:275380	4/22 (18%)
		leucine-rich repeat	581..604	CDD:275380	4/22 (18%)
		leucine-rich repeat	605..628	CDD:275380	4/23 (17%)
		PPP1R42	627..860	CDD:455733	72/241 (30%)
		leucine-rich repeat	629..652	CDD:275380	8/22 (36%)
		leucine-rich repeat	653..676	CDD:275380	6/22 (27%)
		leucine-rich repeat	677..700	CDD:275380	7/22 (32%)
		leucine-rich repeat	701..748	CDD:275380	19/50 (38%)
		leucine-rich repeat	725..736	CDD:275378	5/10 (50%)
		leucine-rich repeat	749..772	CDD:275380	3/22 (14%)
		leucine-rich repeat	773..793	CDD:275380	6/23 (26%)
		leucine-rich repeat	821..844	CDD:275380	5/22 (23%)
		leucine-rich repeat	845..868	CDD:275380	6/22 (27%)
		LRR	869..1226	CDD:443914	47/237 (20%)
		leucine-rich repeat	869..892	CDD:275380	6/22 (27%)
		leucine-rich repeat	893..915	CDD:275380	6/24 (25%)
		leucine-rich repeat	916..944	CDD:275380	3/27 (11%)
		leucine-rich repeat	945..968	CDD:275380	8/23 (35%)
		leucine-rich repeat	969..992	CDD:275380	2/22 (9%)
		leucine-rich repeat	993..1014	CDD:275380	5/26 (19%)
		leucine-rich repeat	1017..1040	CDD:275380	4/24 (17%)
		leucine-rich repeat	1041..1064	CDD:275380	7/44 (16%)
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		PPP1R42	1155..1317	CDD:455733
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380