DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cDIP and CG42346

DIOPT Version :9

Sequence 1:NP_650951.1 Gene:cDIP / 42512 FlyBaseID:FBgn0038865 Length:554 Species:Drosophila melanogaster
Sequence 2:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster


Alignment Length:607 Identity:144/607 - (23%)
Similarity:239/607 - (39%) Gaps:141/607 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 DADVDSGSSRIVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLP--TEVRIAEDGTTYEVGD 91
            |..|...:.|:..|.....|..|.|.|.|               :||  .||.::|:.......|
  Fly   524 DPKVFEKNKRLQTVDLSHNHIHTIGGVFS---------------NLPQLREVFLSENNILELPAD 573

  Fly    92 EEHSRT----LIFENCTFTNFPLRLFYTL-EVSELDMRGCGIRFIYWENFSIGADKLVILLLSDN 151
            ...:.|    :..|:....:....:|.|| .:..|.:|...|..:....|. .:.||..|.|.:|
  Fly   574 AFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFD-KSTKLTSLSLDNN 637

  Fly   152 HIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLR 216
            .|:.|....||...:|..:.|:.|::.:::.|.|:.|..||.|.:.:|.:|.:....|..|::::
  Fly   638 EIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQ 702

  Fly   217 HVGLAGNQLTTIESDLFA-HNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN------ 274
            |:.|..||||.:| |:|. .|..||||.::.|.|.:|....|   .|..::|.:.|.:|      
  Fly   703 HINLQDNQLTVLE-DIFPDENSSLLSVQLEANYLHKVHPRTF---SRQQKVQIMWLKDNQLTRVE 763

  Fly   275 -------PELVVLLLNINATNLTARNCSLDR-VNLYGSVTNVDLSDNRVREL---YFPASEALEH 328
                   |:|..|.|:.|    ..|:...|. |||. .:..:|||.|::|:|   ||...:.||.
  Fly   764 RSFFADTPQLGRLYLSDN----KIRDIEKDTFVNLL-LLQFLDLSGNQLRQLRRDYFAPLQDLEE 823

  Fly   329 LVLRNNSL--VQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPH-LEMLVLRNTGQMELPLEALQ 390
            |.|..|.:  ::..:.:::..|:.||::.||.:....|.:.... |..|.|.|....:|...|.:
  Fly   824 LSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFK 888

  Fly   391 GMQNLQKLDISGNNLTEIDPSAFPTL--TQLTHFYIHGNNW------------------------ 429
            .:.||.:|::..|   :::|:...||  ..|....:..||:                        
  Fly   889 SLTNLNELNLERN---QLNPADIQTLDIPNLRRLLLSHNNFSYAGSVGIMAGMLDRLRSLQQLSM 950

  Fly   430 -NCFSLRNIMDVLIRANGIAYTVDNYD---------------------------PDFPGEYFHGI 466
             || ||..|.|:|...|.....:|..|                           .|||    |  
  Fly   951 SNC-SLGQIPDLLFAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFP----H-- 1008

  Fly   467 ACMYRLPEKEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFSKLAQ 531
            ..:|.|...|.:|.:.:.  .||::...::.:.:..:: .|||                 :|:..
  Fly  1009 IALYNLSTLESLDLARNQ--LASIDFFKLSGTLNLRQL-ILRD-----------------NKITA 1053

  Fly   532 LNEQIQAFEVLNKTVWSQVTLS 553
            |:    .|..:|.|....|.||
  Fly  1054 LS----GFNAVNLTQLDSVDLS 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cDIPNP_650951.1 leucine-rich repeat 118..142 CDD:275380 4/23 (17%)
LRR_RI 143..407 CDD:238064 82/284 (29%)
leucine-rich repeat 143..166 CDD:275380 8/22 (36%)
LRR_8 166..225 CDD:290566 16/58 (28%)
leucine-rich repeat 167..190 CDD:275380 6/22 (27%)
leucine-rich repeat 191..214 CDD:275380 7/22 (32%)
leucine-rich repeat 215..238 CDD:275380 10/23 (43%)
leucine-rich repeat 239..265 CDD:275380 9/25 (36%)
leucine-rich repeat 266..325 CDD:275380 21/75 (28%)
LRR_8 304..357 CDD:290566 16/57 (28%)
leucine-rich repeat 326..347 CDD:275380 5/22 (23%)
leucine-rich repeat 348..394 CDD:275380 12/46 (26%)
LRR_8 369..428 CDD:290566 14/61 (23%)
LRR_4 393..433 CDD:289563 12/66 (18%)
leucine-rich repeat 395..418 CDD:275380 6/24 (25%)
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064 31/139 (22%)
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566
leucine-rich repeat 486..509 CDD:275380
LRR_8 508..567 CDD:290566 14/57 (25%)
leucine-rich repeat 510..533 CDD:275380 2/8 (25%)
LRR_RI 527..785 CDD:238064 72/281 (26%)
leucine-rich repeat 534..556 CDD:275380 7/36 (19%)
LRR_8 555..613 CDD:290566 12/57 (21%)
leucine-rich repeat 557..580 CDD:275380 4/22 (18%)
leucine-rich repeat 581..604 CDD:275380 4/22 (18%)
LRR_8 604..663 CDD:290566 16/59 (27%)
leucine-rich repeat 605..628 CDD:275380 4/23 (17%)
leucine-rich repeat 629..652 CDD:275380 8/22 (36%)
LRR_8 652..711 CDD:290566 16/58 (28%)
leucine-rich repeat 653..676 CDD:275380 6/22 (27%)
leucine-rich repeat 677..700 CDD:275380 7/22 (32%)
leucine-rich repeat 701..748 CDD:275380 19/50 (38%)
leucine-rich repeat 725..736 CDD:275378 5/10 (50%)
leucine-rich repeat 749..772 CDD:275380 3/22 (14%)
LRR_8 771..831 CDD:290566 23/64 (36%)
leucine-rich repeat 773..793 CDD:275380 6/23 (26%)
LRR_RI 804..1076 CDD:238064 63/302 (21%)
LRR_8 821..903 CDD:290566 21/84 (25%)
leucine-rich repeat 821..844 CDD:275380 5/22 (23%)
leucine-rich repeat 845..868 CDD:275380 6/22 (27%)
leucine-rich repeat 869..892 CDD:275380 6/22 (27%)
leucine-rich repeat 893..915 CDD:275380 6/24 (25%)
leucine-rich repeat 916..944 CDD:275380 3/27 (11%)
leucine-rich repeat 945..968 CDD:275380 8/23 (35%)
LRR_8 967..1027 CDD:290566 10/67 (15%)
leucine-rich repeat 969..992 CDD:275380 2/22 (9%)
leucine-rich repeat 993..1014 CDD:275380 5/26 (19%)
LRR_8 1015..1075 CDD:290566 15/81 (19%)
leucine-rich repeat 1017..1040 CDD:275380 4/24 (17%)
leucine-rich repeat 1041..1064 CDD:275380 7/44 (16%)
LRR_RI <1047..1244 CDD:238064 10/46 (22%)
LRR_8 1063..1125 CDD:290566 4/9 (44%)
leucine-rich repeat 1089..1114 CDD:275380
leucine-rich repeat 1115..1162 CDD:275380
LRR_8 1163..1219 CDD:290566
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453708
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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