DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cDIP and Lrig3

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_796126.4	Gene:	Lrig3 / 320398	MGIID:	2443955	Length:	1117	Species:	Mus musculus

Alignment Length:	333	Identity:	79/333 - (23%)
Similarity:	150/333 - (45%)	Gaps:	26/333 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQA 182
            :.:|.:.|..|..|..|... ....|..|.||:|:|..|  :|......|:::::|.|::..::.
Mouse   123 IRQLSLAGNAIDKILPEQLE-AFQSLETLDLSNNNISEL--RTAFPPLQLKYLYINNNRVSSMEP 184

  Fly   183 GAFDNLLK-LQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQN 246
            |.||||.. |..|.|..||:.|:...:|. |..|:|:.|..|::..::...|.....|.|:.||.
Mouse   185 GYFDNLASTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 248

  Fly   247 NRLREVGEYAFRSRGRHHQMQYVDLSNNPEL-------VVLLLNINATNLTARNCSLDRVNLYGS 304
            |.:.::.:.||........:| :|.:|..|:       :::|..::.:.......|.|.......
Mouse   249 NGVTKLMDGAFWGLSNMEVLQ-LDHNNLTEITKGWLYGLLMLRELHLSQNAINRISPDAWEFCQK 312

  Fly   305 VTNVDLSDN---RVRELYFPASEALEHLVLRNNSLVQLA--SLSRVPRLRHLDVADNPNLGQLPD 364
            ::.:||:.|   |:.:..|.....|..|.:.||.:..:|  :...:..|:.||:.:|.....:.|
Mouse   313 LSELDLTFNHLSRLDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLKTLDLRNNEISWTIED 377

  Fly   365 ------GWRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFY 423
                  |  ...|..|:|:......:..:|..|:..|:.||:|||.:..:..:||..:.:|...:
Mouse   378 MSGAFSG--LDRLRQLILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSNAFSQMKKLQQLH 440

  Fly   424 IHGNNWNC 431
            ::.::..|
Mouse   441 LNTSSLLC 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	5/23 (22%)
		LRR_RI	143..407	CDD:238064	70/282 (25%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		LRR_8	166..225	CDD:290566	20/59 (34%)
		leucine-rich repeat	167..190	CDD:275380	8/22 (36%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		leucine-rich repeat	239..265	CDD:275380	7/25 (28%)
		leucine-rich repeat	266..325	CDD:275380	12/68 (18%)
		LRR_8	304..357	CDD:290566	13/57 (23%)
		leucine-rich repeat	326..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..394	CDD:275380	11/51 (22%)
		LRR_8	369..428	CDD:290566	14/58 (24%)
		LRR_4	393..433	CDD:289563	10/39 (26%)
		leucine-rich repeat	395..418	CDD:275380	8/22 (36%)
Lrig3	NP_796126.4	LRR 1	75..98
		LRR_8	76..133	CDD:290566	2/9 (22%)
		leucine-rich repeat	76..99	CDD:275378
		LRR_RI	81..324	CDD:238064	51/205 (25%)
		LRR 2	99..120
		leucine-rich repeat	100..146	CDD:275378	5/23 (22%)
		LRR_8	122..179	CDD:290566	16/58 (28%)
		LRR 3	122..143		5/20 (25%)
		LRR 4	146..168		8/23 (35%)
		leucine-rich repeat	147..168	CDD:275380	8/22 (36%)
		LRR_8	168..227	CDD:290566	20/59 (34%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		LRR 5	169..189		5/19 (26%)
		LRR 6	193..214		7/21 (33%)
		leucine-rich repeat	194..216	CDD:275380	8/22 (36%)
		LRR_8	215..275	CDD:290566	14/60 (23%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..240	CDD:275380	5/22 (23%)
		LRR 8	240..261		7/20 (35%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR_RI	262..>446	CDD:238064	37/186 (20%)
		LRR_8	263..323	CDD:290566	10/60 (17%)
		LRR 9	264..285		4/21 (19%)
		leucine-rich repeat	265..288	CDD:275380	4/23 (17%)
		LRR 10	288..309		3/20 (15%)
		leucine-rich repeat	289..312	CDD:275380	3/22 (14%)
		LRR_8	312..371	CDD:290566	14/58 (24%)
		LRR 11	312..333		5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	5/22 (23%)
		LRR 12	336..357		5/20 (25%)
		leucine-rich repeat	337..360	CDD:275380	5/22 (23%)
		LRR_8	359..422	CDD:290566	17/64 (27%)
		LRR 13	360..382		5/21 (24%)
		leucine-rich repeat	361..385	CDD:275380	6/25 (24%)
		LRR 14	387..408		4/20 (20%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		8/20 (40%)
		leucine-rich repeat	412..433	CDD:275380	8/20 (40%)
		LRRCT	446..494	CDD:214507	1/3 (33%)
		I-set	499..599	CDD:254352
		Ig	500..587	CDD:299845
		I-set	603..693	CDD:254352
		Ig_1	620..694	CDD:143240
		I-set	697..784	CDD:254352
		IGc2	711..774	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010