DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cDIP and Lrrc15

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_659551.1	Gene:	Lrrc15 / 246296	RGDID:	70551	Length:	578	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	96/345 - (27%)
Similarity:	149/345 - (43%)	Gaps:	38/345 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFA 210
            |.:.:.||..||...|.....|..:.:.:|:|..:..|||.||..|:||.|..|:|..|...||.
  Rat    58 LQVVNTHITELPENLFLNISALIALKMEKNELSTIMPGAFRNLGSLRYLSLANNKLRMLPIRVFQ 122

  Fly   211 GLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAF--------RSRGRHHQMQ 267
            .:.:|..:.|:.|||..|:...|:...:|..:.:..|.|..:.|.||        .:.||:   .
  Rat   123 DVNNLESLLLSNNQLVQIQPAQFSQFSNLRELQLHGNNLESIPEEAFDHLVGLTKLNLGRN---S 184

  Fly   268 YVDLSNNPELVVLLLNINATNLTARNCS---LDRVNLYGSVTNVDLSDNRVREL---YFPASEAL 326
            :..||  |.|...|.|:....|.....|   :...:..|::..:.|.:|::..|   .|..:..|
  Rat   185 FTHLS--PRLFQHLGNLQVLRLHENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNL 247

  Fly   327 EHLVLRNNSLVQL--ASLSRVPRLRHLDVADNPNLGQLPDG--WRTPHLEMLVLRNTGQMELPLE 387
            :.|.|.||.:.||  ....::|:|..|.:..| :|.:|..|  ...|:|..|.|.|.....|...
  Rat   248 QRLYLSNNHISQLPPGIFMQLPQLNKLTLFGN-SLRELSPGVFGPMPNLRELWLYNNHITSLADN 311

  Fly   388 ALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGN-----NWNCF-SLRNIMDVLIRANG 446
            ....:..||.|.:|.|.||.|.|.||..||.|....:|.|     :.|.| ||.|:.::.:::|.
  Rat   312 TFSHLNQLQVLILSHNQLTYISPGAFNGLTNLRELSLHTNALQDLDSNVFRSLANLQNISLQSNR 376

  Fly   447 IAYTVDNYDPDFPGEYFHGI 466
            :.        ..||..|..:
  Rat   377 LR--------QLPGSIFANV 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380
		LRR_RI	143..407	CDD:238064	77/278 (28%)
		leucine-rich repeat	143..166	CDD:275380	6/19 (32%)
		LRR_8	166..225	CDD:290566	20/58 (34%)
		leucine-rich repeat	167..190	CDD:275380	8/22 (36%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	8/33 (24%)
		leucine-rich repeat	266..325	CDD:275380	13/64 (20%)
		LRR_8	304..357	CDD:290566	14/57 (25%)
		leucine-rich repeat	326..347	CDD:275380	7/22 (32%)
		leucine-rich repeat	348..394	CDD:275380	12/47 (26%)
		LRR_8	369..428	CDD:290566	22/63 (35%)
		LRR_4	393..433	CDD:289563	18/45 (40%)
		leucine-rich repeat	395..418	CDD:275380	12/22 (55%)
Lrrc15	NP_659551.1	LRR_8	54..113	CDD:290566	19/54 (35%)
		LRR 1	54..75		6/16 (38%)
		LRR 2	78..99		6/20 (30%)
		leucine-rich repeat	79..102	CDD:275380	8/22 (36%)
		LRR_RI	<94..303	CDD:238064	60/214 (28%)
		LRR_8	102..161	CDD:290566	18/58 (31%)
		LRR 3	102..123		9/20 (45%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		LRR 4	126..147		7/20 (35%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR_8	149..209	CDD:290566	15/64 (23%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		LRR 6	174..195		6/25 (24%)
		leucine-rich repeat	175..198	CDD:275380	7/27 (26%)
		LRR_8	198..257	CDD:290566	13/58 (22%)
		LRR 7	198..219		3/20 (15%)
		leucine-rich repeat	199..222	CDD:275380	2/22 (9%)
		LRR 8	222..243		4/20 (20%)
		leucine-rich repeat	223..246	CDD:275380	4/22 (18%)
		LRR_8	245..305	CDD:290566	19/60 (32%)
		LRR 9	246..267		7/20 (35%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		LRR 10	270..291		6/21 (29%)
		leucine-rich repeat	271..294	CDD:275380	6/23 (26%)
		LRR_8	293..353	CDD:290566	22/59 (37%)
		LRR 11	294..315		5/20 (25%)
		leucine-rich repeat	295..318	CDD:275380	5/22 (23%)
		LRR_4	318..358	CDD:289563	16/39 (41%)
		LRR 12	318..339		11/20 (55%)
		leucine-rich repeat	319..342	CDD:275380	12/22 (55%)
		LRR 13	342..363		5/20 (25%)
		leucine-rich repeat	343..364	CDD:275380	5/20 (25%)
		LRR_8	366..424	CDD:290566	5/31 (16%)
		LRR 14	366..387		5/28 (18%)
		leucine-rich repeat	367..387	CDD:275380	4/27 (15%)
		LRR 15	390..411
		leucine-rich repeat	391..412	CDD:275380
		TPKR_C2	423..>462	CDD:301599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010