DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and lron-14

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001255400.1	Gene:	lron-14 / 188075	WormBaseID:	WBGene00011454	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	152/690 - (22%)
Similarity:	243/690 - (35%)	Gaps:	223/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPFLCSYLLISL--AATATTDE---------DADADVDSGS------------------SRIVLV 42
            ||.|..:|:.||  |.|||:..         ...||.:...                  :|..||
Worm     4 LPLLHLFLISSLQIAPTATSSPSQFPCPTRCQCYADNEQNQQVHLICKWEQLNVTTLQLARPDLV 68

  Fly    43 SSLEGHCQTEG-KVTSCRGFEFAG-------EDEKATFDLPTEVRIAEDGTTYEVGDEEHSRTLI 99
            .:|...|.... ||::.....|.|       |.::...|...|...|..|..|         :||
Worm    69 RTLTIKCPYHSPKVSTPPHSLFQGFRNLDRLELDRCLIDTVPEGLFAGLGQLY---------SLI 124

  Fly   100 FENCTFTNFPLRLF-YTLEVSELDMRGCGIRFIYWENFSI-GADKLVILLLSDNHIEVLPTKTFR 162
            .:|...|:||..:| :...:..||:.|..:|.   |.:|: ....|:.|.:|||.|..| |.|..
Worm   125 VKNAKITDFPREIFAHVPNLMTLDLSGNRLRI---EPYSLRSLQNLIHLDVSDNDIGFL-TNTLI 185

  Fly   163 GAGNLEFIFLNRNKLGKLQAGAF-DNLL--------------------KLQYLDLTENRLEAL-- 204
            ....|:.|.:|.||:..:....| :||.                    .|:.|||..||:|.:
Worm   186 SLTKLKVITMNNNKITNIDFRRFPENLTDLSIRHNLVSTIHYVPASARNLKRLDLAGNRMEFVGG 250

  Fly   205 ----AADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQ 265
                |.:|...  .|:||.|:.|:||.:....|.|..:|:.:.::||.|:||...:|  .|...|
Worm   251 LTTGAVNVLPA--ELKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNSLKEVKSSSF--AGSKFQ 311

  Fly   266 MQYVDLSNNPELVVLLLNIN---ATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALE 327
            :: :.||.||    ||.:.|   ..:.:|:|.|:.           ||.......:..|..:.|.
Worm   312 VK-LFLSENP----LLCHCNHKWLMDSSAKNISIG-----------DLQTIECLNILKPEKKMLL 360

  Fly   328 HLVLRNNSL--------------------------------VQLASLSRVPRLRHLDVADN---P 357
            .|....|.|                                ::.|.:|.|...:::.|.|.   .
Worm   361 TLAHSRNQLLCKYSNMCEADCECCQKKECECRFECPPTCKCLRSADVSIVRTSQNIMVCDKLRWD 425

  Fly   358 NLGQLPD----------GWR---------TPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGN 403
            .||:.|.          .|:         ..:|..|.:.|:....:.:|.|..:.||..|:|:.:
Worm   426 KLGKFPSPLTQLHMNQTDWKIFETEKLKELSNLRALKITNSKMTSVEMEKLTDLANLTHLEITSS 490

  Fly   404 NLTEIDPSAFPTLTQLTHFYIHGNNWNCFSLR--NIMDVL--IRANGIAYTVDNY-----DPDFP 459
            .:|.| |.....|..|||.|:..|..:..|..  |.:|.|  ||..|      |:     |.:.|
Worm   491 AITSI-PETITKLPSLTHLYLSDNPLDQLSSTSLNHLDGLKKIRLGG------NFSRFACDCESP 548

  Fly   460 GEY----------------------FHGIACMYRLPEKEGVDSS--------------------- 481
            .::                      .:|...::.|....|.:.|
Worm   549 SDFQRWLMRRINRAKIDDIDDLYCDLNGHGTVWMLEALPGTNESVCLDPTEETKQWMTFVENAQK 613

  Fly   482 -------SSSEISASVESSPITSSSDPSEVDKLRDELKAV 514
                   :|:|.:...|.:.:|::...|.:|.: |||:.|
Worm   614 GIMERVYTSTESTTKSEKTMMTTTLKKSILDTM-DELEGV 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/24 (25%)
		LRR_RI	143..407	CDD:238064	79/347 (23%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	22/85 (26%)
		leucine-rich repeat	167..190	CDD:275380	8/43 (19%)
		leucine-rich repeat	191..214	CDD:275380	9/28 (32%)
		leucine-rich repeat	215..238	CDD:275380	9/22 (41%)
		leucine-rich repeat	239..265	CDD:275380	8/25 (32%)
		leucine-rich repeat	266..325	CDD:275380	13/61 (21%)
		LRR_8	304..357	CDD:290566	12/87 (14%)
		leucine-rich repeat	326..347	CDD:275380	7/52 (13%)
		leucine-rich repeat	348..394	CDD:275380	11/67 (16%)
		LRR_8	369..428	CDD:290566	17/58 (29%)
		LRR_4	393..433	CDD:289563	13/39 (33%)
		leucine-rich repeat	395..418	CDD:275380	7/22 (32%)
lron-14	NP_001255400.1	leucine-rich repeat	98..119	CDD:275380	4/20 (20%)
		LRR_8	119..177	CDD:290566	19/69 (28%)
		leucine-rich repeat	120..143	CDD:275380	8/31 (26%)
		LRR_RI	142..389	CDD:238064	67/270 (25%)
		leucine-rich repeat	144..166	CDD:275380	6/24 (25%)
		leucine-rich repeat	167..189	CDD:275380	9/22 (41%)
		leucine-rich repeat	190..211	CDD:275380	6/20 (30%)
		leucine-rich repeat	212..234	CDD:275380	1/21 (5%)
		leucine-rich repeat	235..261	CDD:275380	9/25 (36%)
		LRR_8	262..321	CDD:290566	22/65 (34%)
		leucine-rich repeat	263..286	CDD:275380	9/22 (41%)
		leucine-rich repeat	287..310	CDD:275380	8/24 (33%)
		leucine-rich repeat	349..404	CDD:275380	5/54 (9%)
		LRR_8	456..515	CDD:290566	18/59 (31%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		LRR_4	481..520	CDD:289563	13/39 (33%)
		leucine-rich repeat	482..504	CDD:275380	7/22 (32%)
		leucine-rich repeat	505..526	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910