DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and lron-5

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_497943.2	Gene:	lron-5 / 184307	WormBaseID:	WBGene00008656	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	122/498 - (24%)
Similarity:	180/498 - (36%)	Gaps:	149/498 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PLRLFY-TLEVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIFL 172
            |..||: .|.|  |.|..||:..|....| :....|.::.||:||:|.||....|....|..:.|
Worm    65 PHFLFHPNLRV--LRMSRCGMHEIPGSTF-LPLPGLEVIDLSNNHLETLPPTVLRSLKFLRVLIL 126

  Fly   173 NRNKLGKLQAGAFDNL-------LKLQYLDLTENRLE-ALAADVFAGLKSLRHVGLAGNQLTTI- 228
            :.|:|..|     |.|       :.|:.|||:.|.:. |.:..||   ..:|.:.|:..::.::
Worm   127 SNNRLSNL-----DQLTWILAPGVVLEQLDLSGNPIAIATSMTVF---PPVRQLFLSDTRMESVN 183

  Fly   229 -------------ESDLFAHNP-------DLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSN 273
                         :.|:..|.|       .:.::...:||..|:...|.   .......||||||
Worm   184 ETAIMFKKLPGKCDRDVCRHIPIHNLNVSIITTIDFSSNRDLEIDSGAL---DVFSNATYVDLSN 245

  Fly   274 NPELV-----------VLLLNINATNL-----TARNC-----SLD---------RVNLYGSVTNV 308
            ....|           |..|||:...|     |...|     |||         |.:.:..:.:|
Worm   246 TRLPVGFEEWLERKSRVKSLNISHCQLPLHEDTWTACGQFLHSLDISGIGAKRLRFSRFCPIRSV 310

  Fly   309 DLSDNRVRELYFPASEALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEM 373
            ...||.:..:|..| .::|.|.|..|...:..    :|                |.|.....|..
Worm   311 FARDNLISSVYIDA-VSMESLHLERNMFSEFP----IP----------------PPGVELTELHT 354

  Fly   374 LVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPT--------------LTQLTHFYI 424
            |.|.:.....||..|||...|||..|:|.|.|:||||.|||:              |:.|.|
Worm   355 LGLSHNLMTSLPPHALQSYPNLQHFDVSSNQLSEIDPQAFPSIGLGLISLDLSSNQLSSLPH--- 416

  Fly   425 HGNNWNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIACMYRLPEKEGVDSSSSSEISAS 489
                       .|:..|:..:....|:.:.||.|    |.|:..:.:|                .
Worm   417 -----------PILPSLLLLDLSFNTISHLDPHF----FTGLPMLQQL----------------R 450

  Fly   490 VESSPITSSSDPSE-----VDKLRDELKAVVQHFDSKFDLIFS 527
            :.|:|...|..|:.     .|.| |||.::|....|...|.||
Worm   451 IASNPTLFSRCPNRDSPCWSDHL-DELTSLVDLDISNSGLEFS 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	7/23 (30%)
		LRR_RI	143..407	CDD:238064	78/322 (24%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	17/66 (26%)
		leucine-rich repeat	167..190	CDD:275380	7/29 (24%)
		leucine-rich repeat	191..214	CDD:275380	8/23 (35%)
		leucine-rich repeat	215..238	CDD:275380	5/43 (12%)
		leucine-rich repeat	239..265	CDD:275380	4/25 (16%)
		leucine-rich repeat	266..325	CDD:275380	23/88 (26%)
		LRR_8	304..357	CDD:290566	10/52 (19%)
		leucine-rich repeat	326..347	CDD:275380	4/20 (20%)
		leucine-rich repeat	348..394	CDD:275380	10/45 (22%)
		LRR_8	369..428	CDD:290566	25/72 (35%)
		LRR_4	393..433	CDD:289563	17/53 (32%)
		leucine-rich repeat	395..418	CDD:275380	14/36 (39%)
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380	3/6 (50%)
		LRR_8	72..131	CDD:338972	20/61 (33%)
		leucine-rich repeat	73..96	CDD:275380	8/25 (32%)
		LRR	<92..>272	CDD:227223	44/190 (23%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..146	CDD:275380	7/29 (24%)
		leucine-rich repeat	147..168	CDD:275380	8/23 (35%)
		leucine-rich repeat	169..208	CDD:275380	5/38 (13%)
		leucine-rich repeat	209..237	CDD:275380	4/30 (13%)
		leucine-rich repeat	238..284	CDD:275380	14/45 (31%)
		leucine-rich repeat	327..351	CDD:275380	7/43 (16%)
		internalin_A	345..>576	CDD:380193	49/183 (27%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..391	CDD:275380	8/14 (57%)
		leucine-rich repeat	401..445	CDD:275380	11/61 (18%)
		leucine-rich repeat	446..478	CDD:275380	10/48 (21%)
		leucine-rich repeat	479..500	CDD:275380	5/14 (36%)
		leucine-rich repeat	501..522	CDD:275380
		leucine-rich repeat	523..544	CDD:275380
		LRRCT	553..601	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010