DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cDIP and let-4

DIOPT Version :9

Sequence 1:NP_650951.1 Gene:cDIP / 42512 FlyBaseID:FBgn0038865 Length:554 Species:Drosophila melanogaster
Sequence 2:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans


Alignment Length:426 Identity:98/426 - (23%)
Similarity:169/426 - (39%) Gaps:109/426 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 LVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAAD 207
            |.:|.|:.|.|..|..:.|....:|.:::|:.||:.||.|..|....:|:.||||.|.:.|:.|:
 Worm   234 LNLLNLAGNQIHELNRQAFLNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPAN 298

  Fly   208 VFAGLKSLRHVGLAGNQLTTIESDLFAHN-----------------------PDLLSVAMQNNRL 249
            ..:|||.||.:.||.|:::.|.|:.|.::                       |:|..|:.::|::
 Worm   299 SLSGLKQLRQLYLAHNKISNISSNAFTNSSIVVLVLSSNELKTLTAGIISGLPNLQQVSFRDNQI 363

  Fly   250 REVGEYAFRSRGRHHQMQYVDLSNNPELVVLLLNINATNLTARNCSLDRVNLYGSVTNVDLSDNR 314
            :.:...||....              .||:|.|..|.....|....|.::||    ..||||:|:
 Worm   364 KTINRNAFYDAA--------------SLVMLDLAKNQLTEIAPTTFLAQLNL----LLVDLSENK 410

  Fly   315 VRELYFPA-SEALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNL--GQLPDGWRTPHLEMLVL 376
            :.:..:.| :..:..::|:.|.||...:|..:.:...:.|.|:|::  |:.|    ||..|.:: 
 Worm   411 LPKTPYSAFNSRVGTVLLKENPLVCTENLHMLQQGTGVYVRDSPDIICGRKP----TPKPEPVL- 470

  Fly   377 RNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVL 441
                 :.:..::|...|.                   |.|.|:....||.|              
 Worm   471 -----VPIVTDSLISTQR-------------------PALVQIPKMQIHRN-------------- 497

  Fly   442 IRANGIAYTVDNYDPDFPGEYFHGI--ACMYRLPEKEG---VDSSSSSE--ISASVESSPITSSS 499
                 :..|..:..|..|...|..|  .....||....   :|..|:.|  :..:.|.:||....
 Worm   498 -----VHTTTGDQAPQIPSGAFQQIDLGKSRSLPRGHSRFILDKPSTREQSVEPTEELTPIQPII 557

  Fly   500 DPSEVDKLR----------DELKAVVQHFDSKFDLI 525
            .||..|::|          :.::|..|...|..|:|
 Worm   558 LPSREDEIRQSSMEAGTSQESVEATSQKIPSTTDII 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cDIPNP_650951.1 leucine-rich repeat 118..142 CDD:275380
LRR_RI 143..407 CDD:238064 70/289 (24%)
leucine-rich repeat 143..166 CDD:275380 7/22 (32%)
LRR_8 166..225 CDD:290566 24/58 (41%)
leucine-rich repeat 167..190 CDD:275380 8/22 (36%)
leucine-rich repeat 191..214 CDD:275380 10/22 (45%)
leucine-rich repeat 215..238 CDD:275380 8/45 (18%)
leucine-rich repeat 239..265 CDD:275380 5/25 (20%)
leucine-rich repeat 266..325 CDD:275380 15/59 (25%)
LRR_8 304..357 CDD:290566 13/53 (25%)
leucine-rich repeat 326..347 CDD:275380 5/20 (25%)
leucine-rich repeat 348..394 CDD:275380 9/47 (19%)
LRR_8 369..428 CDD:290566 9/58 (16%)
LRR_4 393..433 CDD:289563 7/39 (18%)
leucine-rich repeat 395..418 CDD:275380 2/22 (9%)
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380
LRR_RI <71..275 CDD:238064 14/40 (35%)
LRR_8 88..146 CDD:290566
leucine-rich repeat 88..111 CDD:275380
leucine-rich repeat 112..135 CDD:275380
leucine-rich repeat 136..160 CDD:275380
LRR_8 156..220 CDD:290566
leucine-rich repeat 161..184 CDD:275380
leucine-rich repeat 186..209 CDD:275380
leucine-rich repeat 210..257 CDD:275380 7/22 (32%)
LRR_RI <250..411 CDD:238064 48/178 (27%)
LRR_8 256..316 CDD:290566 24/59 (41%)
leucine-rich repeat 258..281 CDD:275380 8/22 (36%)
leucine-rich repeat 282..305 CDD:275380 10/22 (45%)
leucine-rich repeat 306..328 CDD:275380 8/21 (38%)
LRR_8 327..387 CDD:290566 11/73 (15%)
leucine-rich repeat 329..350 CDD:275380 0/20 (0%)
leucine-rich repeat 353..400 CDD:275380 12/60 (20%)
leucine-rich repeat 356..376 CDD:275380 4/33 (12%)
leucine-rich repeat 401..419 CDD:275380 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.