DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and lron-1

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_510424.4	Gene:	lron-1 / 181553	WormBaseID:	WBGene00008093	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	110/468 - (23%)
Similarity:	174/468 - (37%)	Gaps:	126/468 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TATTDEDADADVDSGSSRIVLVSSLEGHCQTEGKVT-------SCRGFEFAGEDEKATFDLPTEV 78
            |:|..|....:.|.|||...::.||....|....:|       ...|:.|.|...|..|
Worm    30 TSTRYEAVSINCDGGSSLDAVLESLSNSPQAIDSLTISNTPIEKMPGYAFQGFQIKKLF------ 88

  Fly    79 RIAEDGTTYEVGDEEHSRTLIFENCTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGADKL 143
             :..:|..            .|...|||.   .|..:||  ||::||..|..|.....|| ..:|
Worm    89 -LRNNGLR------------SFHPNTFTG---NLENSLE--ELEIRGNYIDGIPQSGVSI-LKQL 134

  Fly   144 VILLLSDNHIEVLPTKTF---------------------------RGAGNLEFIFLNRNKLGKLQ 181
            .||.|.||.||.:....|                           .|..||..:.|::|.|.::.
Worm   135 KILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHPTGLLGLENLSQLSLDKNLLSEIP 199

  Fly   182 AGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQN 246
            :.|.:|:..|:.|.|..||:..::.:... |.:|:.:.|..||:..|.||.|:..|.|..:.:.|
Worm   200 SQALENIPSLEDLSLGVNRIHTISRNSLP-LPNLKSLSLEVNQIRLIPSDSFSETPLLSYLYLGN 263

  Fly   247 NRLREVGEYAFRSRGRHHQMQYVDLSNNPELVVLLLNINATNLTARNC----------SLDRVNL 301
            |.|..:....|...|   .::.:.:|||.::..:..|...:....:.|          ||.|:.|
Worm   264 NLLTSIDASMFLHIG---GLKVLSMSNNKDITSIQANGKLSVQQFKLCICILAFQHAPSLIRLEL 325

  Fly   302 YGSVTNVDLSDNRVRELYFPAS-EALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDG 365
            :      |.|.:|:.    |.| :.::|:      .|.|.|.:::.|:.| |...|     ||:
Worm   326 F------DCSISRIE----PKSLQKVQHI------QVILLSRNQITRISH-DTFSN-----LPE- 367

  Fly   366 WRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWN 430
                                         |.:||:|||::..:|..||..|..||...:..|...
Worm   368 -----------------------------LSELDLSGNSINAVDDFAFSQLPMLTSLDLSSNRLE 403

  Fly   431 CFSLRNIMDVLIR 443
            ......|.|.|::
Worm   404 SLPSNVIYDSLMQ 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	8/23 (35%)
		LRR_RI	143..407	CDD:238064	68/301 (23%)
		leucine-rich repeat	143..166	CDD:275380	10/49 (20%)
		LRR_8	166..225	CDD:290566	16/58 (28%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..265	CDD:275380	6/25 (24%)
		leucine-rich repeat	266..325	CDD:275380	14/69 (20%)
		LRR_8	304..357	CDD:290566	12/53 (23%)
		leucine-rich repeat	326..347	CDD:275380	4/20 (20%)
		leucine-rich repeat	348..394	CDD:275380	5/45 (11%)
		LRR_8	369..428	CDD:290566	12/58 (21%)
		LRR_4	393..433	CDD:289563	13/39 (33%)
		leucine-rich repeat	395..418	CDD:275380	10/22 (45%)
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	63/259 (24%)
		leucine-rich repeat	85..109	CDD:275380	8/45 (18%)
		leucine-rich repeat	110..133	CDD:275380	10/25 (40%)
		leucine-rich repeat	134..157	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	1/22 (5%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..231	CDD:275380	6/22 (27%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	6/25 (24%)
		leucine-rich repeat	280..319	CDD:275380	5/38 (13%)
		leucine-rich repeat	320..343	CDD:275380	8/32 (25%)
		LRR_8	343..402	CDD:338972	23/100 (23%)
		leucine-rich repeat	344..367	CDD:275380	8/34 (24%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		leucine-rich repeat	392..410	CDD:275380	3/17 (18%)
		leucine-rich repeat	414..435	CDD:275378	1/3 (33%)
		LRRCT	431..>472	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010