DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cDIP and Gp5

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	401	Identity:	102/401 - (25%)
Similarity:	151/401 - (37%)	Gaps:	116/401 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NFSIGADKLVILLLSDNHI---------EVLPTKTFRGAGN---------------LEFIFLNRN 175
            :|| |...|..|:|||:||         :::..||.|...|               ||.:||:.|
Mouse    69 SFS-GMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHN 132

  Fly   176 KLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLR----------HV--GLAG------ 222
            .|..|....|..|..||.|.|.:|:|..|.|::|:.|:.|:          |:  ||.|
Mouse   133 ALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKLE 197

  Fly   223 ------NQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN-----PE 276
                  ||||:::|.|.::...|..:.::.|.||.|...||...|   .:..:.||.|     |.
Mouse   198 KLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLG---NLSSLTLSGNLLESLPP 259

  Fly   277 LVVLLLNINATNLTARNCSLDRVNLYGSVTNVDLSDNRVREL---YFPASEALEHLVLRNNSLVQ 338
              .|.|:::                  ||:.:.|.:|.:.||   .|.....|..|.|....|..
Mouse   260 --ALFLHVS------------------SVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLST 304

  Fly   339 L--ASLSRVPRLRHLDVADNPNLGQLP-------------------------DGWR-TPHLEMLV 375
            |  |:...:..|:.|.:..||.|..||                         |..| ..||..:.
Mouse   305 LPAAAFRNLSGLQTLGLTRNPRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVS 369

  Fly   376 LRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFS------- 433
            ||:.....||....:.:.:|:.:.:..|.|..:....|..|.|||...:..|.|.|..
Mouse   370 LRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQ 434

  Fly   434 -LRNIMDVLIR 443
             ||:..|:|.|
Mouse   435 WLRHHPDILGR 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	3/6 (50%)
		LRR_RI	143..407	CDD:238064	86/347 (25%)
		leucine-rich repeat	143..166	CDD:275380	10/31 (32%)
		LRR_8	166..225	CDD:290566	26/97 (27%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		leucine-rich repeat	191..214	CDD:275380	10/22 (45%)
		leucine-rich repeat	215..238	CDD:275380	11/46 (24%)
		leucine-rich repeat	239..265	CDD:275380	8/25 (32%)
		leucine-rich repeat	266..325	CDD:275380	13/66 (20%)
		LRR_8	304..357	CDD:290566	15/57 (26%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	15/71 (21%)
		LRR_8	369..428	CDD:290566	14/58 (24%)
		LRR_4	393..433	CDD:289563	11/39 (28%)
		leucine-rich repeat	395..418	CDD:275380	5/22 (23%)
Gp5	NP_032174.2	LRR 1	75..96		7/20 (35%)
		LRR_8	76..134	CDD:290566	16/57 (28%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR 2	99..120		4/20 (20%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		LRR 3	123..144		8/20 (40%)
		LRR_8	124..182	CDD:290566	20/57 (35%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_RI	126..402	CDD:238064	73/298 (24%)
		LRR 4	147..168		9/20 (45%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		LRR 5	171..193		5/21 (24%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		LRR_8	195..254	CDD:290566	17/61 (28%)
		LRR 6	195..216		6/20 (30%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	8/25 (32%)
		LRR_8	243..302	CDD:290566	16/78 (21%)
		LRR 8	243..264		5/22 (23%)
		leucine-rich repeat	244..267	CDD:275380	6/42 (14%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR 10	291..312		6/20 (30%)
		leucine-rich repeat	292..315	CDD:275380	6/22 (27%)
		LRR_8	314..375	CDD:290566	13/60 (22%)
		LRR 11	315..337		7/21 (33%)
		leucine-rich repeat	316..338	CDD:275380	7/21 (33%)
		LRR 12	340..361		1/20 (5%)
		leucine-rich repeat	341..364	CDD:275380	2/22 (9%)
		LRR_8	364..422	CDD:290566	14/57 (25%)
		LRR 13	364..385		6/20 (30%)
		leucine-rich repeat	365..388	CDD:275380	5/22 (23%)
		LRR 14	388..409		4/20 (20%)
		leucine-rich repeat	389..410	CDD:275380	4/20 (20%)
		TPKR_C2	421..>454	CDD:301599	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870