DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cDIP and CPN2

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens

Alignment Length:	396	Identity:	107/396 - (27%)
Similarity:	166/396 - (41%)	Gaps:	57/396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 FAGEDEKAT--FDLPTEVRIAEDGTTYEVGDEEHSRTLIFENCTFTNFPLRLFYT----LEVSEL 121
            |..::|.||  .|:|                 .:::.:||...:||....|.|.:    .:|..|
Human    34 FCSDEELATVPLDIP-----------------PYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81

  Fly   122 DMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFD 186
            :.:.|..|   .:.|. |..:|..|.::.:....|.|..|....:|..:.||.|.|..|..|.|.
Human    82 NTQLCQFR---PDAFG-GLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQ 142

  Fly   187 NLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLRE 251
            :|..|:.|.|..|:|:||...:|..|..|:.:.||.|.|..:..:||.....|.::.:.||.|..
Human   143 HLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207

  Fly   252 VGEYAFRSRGRHHQMQYVDLSNNPELVV-----------LLLNINA-TNLTARNCSLDRVNLYGS 304
            :.:..|...|...:: ::|.:|..||..           |.|..|| |:|     .|......|:
Human   208 LPQGVFGKLGSLQEL-FLDSNNISELPPQVFSQLFCLERLWLQRNAITHL-----PLSIFASLGN 266

  Fly   305 VTNVDLSDNRVREL---YFPASEALEHLVLRNNSLVQLA--SLSRVPRLRHLDVADNPNLGQLPD 364
            :|.:.|..|.:|.|   .|..:..|..|.|.:|.|..:|  :.:.:..||.|.::.|. :..||.
Human   267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA-ITHLPA 330

  Fly   365 G-WRTPHLEMLVLRNTGQMELPL---EALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIH 425
            | :|  .||.||....|...|..   ...|.:..|:.|.:|.|.||.:....|.|...|.:..:|
Human   331 GIFR--DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALH 393

  Fly   426 GNNWNC 431
            ||.|.|
Human   394 GNPWQC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/23 (26%)
		LRR_RI	143..407	CDD:238064	80/284 (28%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		LRR_8	166..225	CDD:290566	22/58 (38%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	6/25 (24%)
		leucine-rich repeat	266..325	CDD:275380	18/73 (25%)
		LRR_8	304..357	CDD:290566	15/57 (26%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	15/49 (31%)
		LRR_8	369..428	CDD:290566	18/61 (30%)
		LRR_4	393..433	CDD:289563	14/39 (36%)
		leucine-rich repeat	395..418	CDD:275380	8/22 (36%)
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	6/35 (17%)
		leucine-rich repeat	30..53	CDD:275380	6/35 (17%)
		leucine-rich repeat	75..98	CDD:275380	6/26 (23%)
		LRR 1	98..119		5/20 (25%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		LRR_8	121..181	CDD:290566	22/59 (37%)
		LRR 2	122..143		8/20 (40%)
		leucine-rich repeat	123..146	CDD:275380	9/22 (41%)
		LRR 3	146..167		8/20 (40%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR_RI	149..>356	CDD:238064	59/215 (27%)
		LRR_8	169..229	CDD:290566	14/60 (23%)
		LRR 4	170..191		7/20 (35%)
		leucine-rich repeat	171..194	CDD:275380	7/22 (32%)
		LRR 5	194..215		5/20 (25%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		LRR_8	218..277	CDD:290566	15/64 (23%)
		LRR 6	218..239		4/21 (19%)
		leucine-rich repeat	219..242	CDD:275380	4/23 (17%)
		LRR 7	242..263		7/25 (28%)
		leucine-rich repeat	243..266	CDD:275380	7/27 (26%)
		LRR 8	266..287		6/20 (30%)
		leucine-rich repeat	267..290	CDD:275380	6/22 (27%)
		LRR 9	290..311		6/20 (30%)
		leucine-rich repeat	291..314	CDD:275380	6/22 (27%)
		LRR_8	294..349	CDD:290566	18/57 (32%)
		LRR 10	314..335		8/23 (35%)
		leucine-rich repeat	315..338	CDD:275380	9/25 (36%)
		LRR 11	338..359		4/20 (20%)
		leucine-rich repeat	339..359	CDD:275380	4/19 (21%)
		LRR 12	362..383		7/20 (35%)
		leucine-rich repeat	363..382	CDD:275380	6/18 (33%)
		leucine-rich repeat	387..399	CDD:275378	5/11 (45%)
		LRRCT	395..446	CDD:214507	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870