DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and slitrk5b

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_002667367.2	Gene:	slitrk5b / 100331252	ZFINID:	ZDB-GENE-110408-55	Length:	856	Species:	Danio rerio

Alignment Length:	589	Identity:	114/589 - (19%)
Similarity:	204/589 - (34%)	Gaps:	196/589 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 FTNFPLRLFYTL--EVSELDMRGCGIRFIYWENFSI-----------------GADKLVILLLSD 150
            ||.:.|.|...|  :||..|       |:::|..:|                 |...|..|.|::
Zfish    76 FTAYHLLLTGNLLKKVSLND-------FLHYEGLTILHLGNNDICEIEAGAFNGLQGLKRLHLNN 133

  Fly   151 NHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSL 215
            |.||.|...||.|..:||::.::.|.:..::..|...|..|:.|.|.:|.|.||..::|..: .|
Zfish   134 NKIEALKDDTFLGLESLEYLQIDYNYISHIEPNALSALRHLEVLILNDNLLSALPHNIFQYV-PL 197

  Fly   216 RHVGLAGNQLTTIE-SDLFAHNPDLLSVAMQNNR-------------LREVG----------EYA 256
            .|:.|.||||..:. |.|..|...::.:.::.|.             |..:.          |..
Zfish   198 THLDLRGNQLKVLPYSGLLEHLSRIVELQLEENAWNCSCELIALKTWLESISYTALVGDVVCETP 262

  Fly   257 FRSRGR-----------------HHQMQYVDLSNNPELV-------------VLLLNINATNL-- 289
            ||..||                 .::| :.:::::.|.|             .:|.:..::.|
Zfish   263 FRLHGRDLDEISKQELCPRRAIAEYEM-HAEMAHSSETVSKTTPATAGFASSTILRSTKSSRLSG 326

  Fly   290 ------TARNCSLDRVNLYG----------------------------------------SVTNV 308
                  |:|:.|....| ||                                        |::::
Zfish   327 KLRVKPTSRSSSSKPQN-YGPMLAYQTKSPVPLDCPNTCTCNLQISDLGLNVNCQERKIESISDL 390

  Fly   309 DLSDNRVRELY-------------FPASEALEHLVLRNN--SLVQLASLSRVPRLRHLDVADNPN 358
            |......:::|             |..:..|:.|.|.||  ::|...:..::..||.|.:  |.|
Zfish   391 DPKPYNPKKMYLTGNYISSVCSSDFSGATGLDLLHLGNNRIAVVHDKTFGQLIHLRRLYL--NGN 453

  Fly   359 L-------------------------GQLPDG--WRTPHLEMLVLRNTGQMELPLEALQGMQNLQ 396
            |                         .::..|  .:.|:|::|.|.|.....|.|....|: ||.
Zfish   454 LIERLTEDMFYGLQSLQFLYLEYNVIREIAVGTFQQLPNLQLLFLNNNLLKTLHLGIFDGL-NLA 517

  Fly   397 KLDISGNNLTEIDP-SAFPTLTQLTHFYIHGNNWNC----FSLRNIMDVLIRANGIAYTVDNYDP 456
            :|::..|:...:.. .....|..|....:..|.|:|    ..::|.::.|.....:...:....|
Zfish   518 RLNLRSNHFRTLPVIGVLDELASLIQIDLFENPWDCSCSILDMKNWLEQLSAGTVVNTVICESPP 582

  Fly   457 DFPGEYFHGIACMYRLPEKEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSK 521
            ...||....|...:..||.   ..:.||.:..|.||.|.::.:..:.:|            ||::
Zfish   583 RLSGEDMRYIRSSHICPES---SIAQSSAVPPSEESFPGSTITLETALD------------FDTQ 632

  Fly   522 FDLI 525
            :..:
Zfish   633 YPAV 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	7/40 (18%)
		LRR_RI	143..407	CDD:238064	80/407 (20%)
		leucine-rich repeat	143..166	CDD:275380	10/22 (45%)
		LRR_8	166..225	CDD:290566	18/58 (31%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..238	CDD:275380	10/23 (43%)
		leucine-rich repeat	239..265	CDD:275380	7/65 (11%)
		leucine-rich repeat	266..325	CDD:275380	15/132 (11%)
		LRR_8	304..357	CDD:290566	13/67 (19%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	15/72 (21%)
		LRR_8	369..428	CDD:290566	14/59 (24%)
		LRR_4	393..433	CDD:289563	9/44 (20%)
		leucine-rich repeat	395..418	CDD:275380	4/23 (17%)
slitrk5b	XP_002667367.2	LRR_8	79..136	CDD:290566	14/63 (22%)
		leucine-rich repeat	80..101	CDD:275380	7/27 (26%)
		LRR_RI	<101..283	CDD:238064	42/182 (23%)
		leucine-rich repeat	102..125	CDD:275380	2/22 (9%)
		LRR_8	125..184	CDD:290566	19/58 (33%)
		leucine-rich repeat	126..149	CDD:275380	10/22 (45%)
		leucine-rich repeat	150..173	CDD:275380	5/22 (23%)
		LRR_8	172..230	CDD:290566	18/58 (31%)
		leucine-rich repeat	174..189	CDD:275380	7/14 (50%)
		leucine-rich repeat	197..221	CDD:275380	10/23 (43%)
		leucine-rich repeat	222..367	CDD:275380	18/146 (12%)
		LRRCT	230..>268	CDD:214507	5/37 (14%)
		leucine-rich repeat	368..420	CDD:275380	4/51 (8%)
		leucine-rich repeat	376..397	CDD:275380	2/20 (10%)
		LRR_8	419..479	CDD:290566	12/61 (20%)
		leucine-rich repeat	421..444	CDD:275380	6/22 (27%)
		LRR_4	444..482	CDD:289563	6/39 (15%)
		leucine-rich repeat	445..468	CDD:275380	6/24 (25%)
		leucine-rich repeat	469..488	CDD:275380	1/18 (6%)
		leucine-rich repeat	493..515	CDD:275380	7/22 (32%)
		leucine-rich repeat	516..540	CDD:275380	4/23 (17%)
		LRRCT	549..599	CDD:214507	9/49 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000