DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and USP15

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001239007.1 Gene:USP15 / 9958 HGNCID:12613 Length:981 Species:Homo sapiens


Alignment Length:845 Identity:179/845 - (21%)
Similarity:272/845 - (32%) Gaps:400/845 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   408 QDYIVENNRLREELSRIQELHN------VTQQLSQKEVEATRNIESKIRERQRLDEQHE------ 460
            |...|::.::...|:.::...|      ||::.|:.:...|  ||.:||:...:.::.|      
Human   120 QGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDT--IEKEIRKIFSIPDEKETRLWNK 182

  Fly   461 --------LERQE---------RERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESL 508
                    |.:.:         :.::|.|.::.:.......||.|.|||         :.:..:|
Human   183 YMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPG---------ASNFSTL 238

  Fly   509 LQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVER--------TSQRVRDFSPVIGQNVGRGLTGL 565
                    |.|:|:...    :.......|||:.        |:.:..|:|.....|...||.||
Human   239 --------PKISPSSLS----NNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGL 291

  Fly   566 KNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKC 628
            .||||||:|||.:|||||||.||||.::|||:..::..|.  ..|::.:..|.|||::|:|::..
Human   292 SNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSY 356

  Fly   629 VASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS-----------A 682
            |..|..:..||::...|.|..|||..|.|..|:|.||.||..:   |::..|.           .
Human   357 VTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKPYIQLKDADGRPDKVV 418

  Fly   683 SEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP-------------- 733
            :|:||....|..:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||              
Human   419 AEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRM 483

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Human   484 DPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDD 548

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Human   549 IYVFEININRTEDTEHVIIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLR 613

  Fly   734 ------------------------------PN--------------------------------- 735
                                          ||                                 
Human   614 MCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENS 678

  Fly   736 -------------SNVC------------------------------------------------ 739
                         :.:|                                                
Human   679 QSEDSVGGDNDSENGLCTEDTCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRL 743

  Fly   740 -------------------------------------------QLNQCMDMYFSGERIHG---WN 758
                                                       :|..|::::.:.|::..   |.
Human   744 DERSFLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWY 808

  Fly   759 CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARA 821
            ||:||..:.|.||||:..||||||||||||     :...||  |....:.||:.:|||:.::...
Human   809 CPNCKEHQQATKKLDLWSLPPVLVVHLKRF-----SYSRYMRDKLDTLVDFPINDLDMSEFLINP 868

  Fly   822 ESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            .:   .|..|.|.|||||||.|.|||||||.|:.:.|||:.|||..||......:||.|||:|||
Human   869 NA---GPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 930

  Fly   887  886
            Human   931  930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 143/652 (22%)
Peptidase_C19R 564..887 CDD:239139 144/652 (22%)
USP15NP_001239007.1 Mediates interaction with SART3. /evidence=ECO:0000269|PubMed:24526689 2..223 16/104 (15%)
UBP12 12..932 CDD:227847 179/845 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..237 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..694 2/64 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 952..981
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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