DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usp8 and USP2

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_004196.4 Gene:USP2 / 9099 HGNCID:12618 Length:605 Species:Homo sapiens


Alignment Length:488 Identity:154/488 - (31%)
Similarity:234/488 - (47%) Gaps:73/488 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   453 QRLDEQHELERQERERLLAIARETKKHYKSPTPSG-PPSPGRNLEDVHVVSDSLESLLQLTGDPD 516
            |:||.|.:|.|.     .:..|.:..:...|...| .|...|..:::    .:|:.|.|....|:
Human   138 QKLDSQSDLARD-----FSSLRTSDSYRIDPRNLGRSPMLARTRKEL----CTLQGLYQTASCPE 193

  Fly   517 ------------------PTIAP--NKAEI--PTF-----------DRAMKPQPRNVERTSQRVR 548
                              |:.||  ...||  ||:           .:...|.|   .|:|...|
Human   194 YLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGP---SRSSSPGR 255

  Fly   549 DFSPVIGQN--VGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVI 611
            |     |.|  ..:||.||:||||||:|||||||||||.:|.:||:...|...:...:..:..::
Human   256 D-----GMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALV 315

  Fly   612 EEVAALIKELWNGQYKCVAS-RDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHV-- 673
            ||.|.||:.:|......|.| .:.:..:.:|...|.|.:|||:.|||..|:|.||:::..:.:  
Human   316 EEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRP 380

  Fly   674 ---PRQREMISASEKA---WLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLEL 732
               |...:.:...||.   |.::.:.::|.|..||.||:||::.|..|...|..::.|.:|||.:
Human   381 KSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 445

  Fly   733 PPNS-NVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPS 793
            .... ....|..||.::...:.:.|   ..|..|:.::..|||..|.:.|.:||:|||||.....
Human   446 AKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRI 510

  Fly   794 NSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYG 858
            .:.   |...::.|||.:||:..:.:...:.||    |.|||||||.||..||||||:|:|...|
Human   511 RTS---KLTTFVNFPLRDLDLREFASENTNHAV----YNLYAVSNHSGTTMGGHYTAYCRSPGTG 568

  Fly   859 KWFKFDDQVVSALDSSNVVSSAAYILFYTWLPP 891
            :|..|:|..|:.:.||.|.:|.||:|||....|
Human   569 EWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 120/336 (36%)
Peptidase_C19R 564..887 CDD:239139 120/335 (36%)
USP2NP_004196.4 Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211 1..200 15/70 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..264 8/34 (24%)
UCH 266..596 CDD:278850 120/336 (36%)
Peptidase_C19R 268..597 CDD:239139 120/335 (36%)
Necessary for interaction with MDM4. /evidence=ECO:0000269|PubMed:19838211 403..503 29/99 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1868
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D469048at33208
OrthoFinder 1 1.000 - - FOG0000821
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101021
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1591
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.750

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