DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and UBP5

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_011071.3	Gene:	UBP5 / 856887	SGDID:	S000000946	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	786	Identity:	199/786 - (25%)
Similarity:	320/786 - (40%)	Gaps:	194/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 DVTYRAP-----------IQIVEGGYEYFIMMYP-THCTNPSVQAPQQN---------------- 289
            |:|.:||           :::.|..:.|::::|. ...|.|.::....|
Yeast    58 DITMQAPKEDANRLSKGFLRLNETAFLYYMIVYTLLEDTLPRLKEFSSNKDQNVRNLYGERIQLL 122

  Fly   290 NND--IETIDDI--EYPSIHDITMKE--DISAK-----------DFRPRPDFNRANKPAATRVNE 337
            :||  ||.|.::  .||....:...|  .:|:.           |.|||.:|.||:      :..
Yeast   123 HNDPNIERIRNVIENYPKFIQLQTIEPGKLSSMLHFHGDALLLIDVRPRSEFVRAH------IKC 181

  Fly   338 QGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQ 402
            :.|            |..|.|.|  :....|:|:|..|.:   .:...|....:...:..|.||.
Yeast   182 KNI------------ICIDPASF--KDSFTDQQIESVSLI---TSPHSDITFFSNRDKFKFIILY 229

  Fly   403 LESKAQDYIVENN---RLREELSRIQELHNVTQQLSQKEVEATRN-----------IESKIRERQ 453
            .:::     :.||   |....|::|...::|.:.||..::....|           .:|.:.|..
Yeast   230 TDTQ-----LHNNFQQRQTRILAKILSQNSVIKPLSGTKILILENGFSNWVKLGGAYQSSVSETA 289

  Fly   454 RL----------------------------DEQHELERQERERLL-AIARETKKHYKSPTPSGP- 488
            .|                            |:...:.....:.|| .:.|.....|.|..|..|
Yeast   290 HLTSSSSTPAFGSPQVPTGLFNQKSLSPNKDKSMPMVSMNTQPLLTTVQRPQLPLYYSDLPIIPQ 354

  Fly   489 PSPGRNLEDVHVVSD---------SLESLLQLTGD------PDPTIAPNKAEIP----TFDRAMK 534
            |||.||...|...|.         :..|.:|...:      ||...|...|.:|    .|...:.
Yeast   355 PSPNRNSPTVQKFSPHPPTTLSKLNTPSTIQNKANTVERISPDIRAAQAHAYLPPASNVFSPRIP 419

  Fly   535 PQP-RNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKN 598
            |.| :|:..:.|.:.:.|.|:..::   :.||:|:||.||||.|||||..|..|....:.:.|.|
Yeast   420 PLPQQNLSSSRQTILNNSQVLDLDL---IVGLENIGNCCYMNCILQCLVGTHDLVRMFLDNTYLN 481

  Fly   599 YI----SRSNKTNGQVIEEVAALIKELW-NGQYKCVASRDLRYVVGQYQKIFRGVD-------QQ 651
            :|    ||.:|  |.:.:..|.|:..:. :|.:.....|.:.....|::||...::       ||
Yeast   482 FINFDSSRGSK--GLLAKNFAILVNNMHRHGAFTPPNVRTIPVQTIQFKKICGHINPMYSDSMQQ 544

  Fly   652 DSHEFLTILMDWLHSDL----QTLHV-------PRQREMIS---ASEKAWLEFTKAKESMILHLF 702
            |..||...|:|.||.||    ...|:       .|.||.:|   ||...|..|.....|.|:.||
Yeast   545 DCQEFCQFLLDGLHEDLNQNGSKKHLKQLSDEEERMREKMSIRKASALEWERFLLTDFSAIIDLF 609

  Fly   703 YGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERI---HGWNCPSCKT 764
            .||..|.::|..|...|.||::||.||:.: |....|.:..|...:...||:   ..|:||.|..
Yeast   610 QGQYASRLQCQVCEHTSTTYQTFSVLSVPV-PRVKTCNILDCFREFTKCERLGVDEQWSCPKCLK 673

  Fly   765 KRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQN-YLRFPLENLDMNPYIARAESR---- 824
            |:.:.|:|.|::||..|:::||||       .:.|.|.| ::::|. :||:.||.||..:.
Yeast   674 KQPSTKQLKITRLPKKLIINLKRF-------DNQMNKNNVFVQYPY-SLDLTPYWARDFNHEAIV 730

  Fly   825 --------AVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALD-SSNVVSSA 880
                    .|.|..|:||.|:.|.|::.|||||::........|:.|||.:...:. |:..::.:
Yeast   731 NEDIPTRGQVPPFRYRLYGVACHSGSLYGGHYTSYVYKGPKKGWYFFDDSLYRPITFSTEFITPS 795

  Fly   881 AYILFY 886
            ||:|||
Yeast   796 AYVLFY 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	7/36 (19%)
		UCH	562..886	CDD:278850	117/366 (32%)
		Peptidase_C19R	564..887	CDD:239139	119/366 (33%)
UBP5	NP_011071.3	RHOD	159..280	CDD:197731	29/148 (20%)
UBP5	NP_011071.3	COG5533	359..805	CDD:227820	137/457 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		mtm9239
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840