Protein Alignment Usp8 and UBP10

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_014213.2
• Gene: UBP10 / 855535
• SGDID: S000005130
• Length: 792
• Species: Saccharomyces cerevisiae
• Alignment Length: 818
• Identity: 181/818 - (22%)
• Similarity: 296/818 - (36%)
• Gaps: 237/818 - (28%)

  Fly   236 TNTAISTLLD-ILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAP----------QQN 289
            |..:|..|:| ||.|         |:|....      |:......|.:..||          |.|
Yeast     3 TQESIKPLVDRILSN---------PLQFNAA------MISNKSNNNDTSAAPENSSYIVIGKQHN 52

  Fly   290 NNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRAN-------------------------- 328
            ||...|       :|......:.|...:...||:..:.|
Yeast    53 NNSNST-------AIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATG 110

  Fly   329 -KPAATRVNEQGISRPSPPAK--PIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGLNA 390
             |.:|....|.....||..::  .:.:...::.|....|....|. .|||...:..|.:|||.:.
Yeast   111 AKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEP-RKASLKERDNADKGDGEDI 174

  Fly   391 TED--QELHFRILQLESKAQDY---IVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIR 450
            .||  :::.      |...:|.   |.||  |...|:.|.:..|..::..:||:..:.:.:.:|.
Yeast   175 GEDIGEDIG------EDIGEDIGEDIGEN--LGSPLATIDDSSNENEKEKRKELSTSISSDDEIE 231

  Fly   451 ERQRLDE--------QHEL-ERQERERLLAIAR-ETKKHYK-------------SPTPSGPPSPG 492
            :.:..|:        :.|| |.:|.:....|:. |.|..|:             .|..:...:..
Yeast   232 DDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGN 296

  Fly   493 RNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTF-----DRAMKPQPRNVERTSQRVRDFSP 552
            ||.:......:..|...:......|....|.:....|     ||......|.|:....:..:..|
Yeast   297 RNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKP 361

  Fly   553 VIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEY---CISDKYKNYISRSNKTNGQVIEEV 614
                      .||.|.|.|||.|:.:|.:.:.|.:..|   .:..||.:.||:::     |...:
Yeast   362 ----------RGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNS-----VSYTL 411

  Fly   615 AALIKELW-----------NGQY---KCVASR--DLRYVVGQYQKIFRGVDQQDSHEFLTILMDW 663
            |...|::|           :..|   |.:.||  |:..::.::|       |:||||:...||..
Yeast   412 AETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQ-------QEDSHEYFMSLMSR 469

  Fly   664 LHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNL 728
            |..|    .||:..::|              ||:|..:|.|.:|..|.|.:|...|.|.:.|.:|
Yeast   470 LQED----SVPKGHKLI--------------ESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDL 516

  Fly   729 SL------ELPPNSNVC------------------------------------------------ 739
            ||      :|.|||::.
Yeast   517 SLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSAN 581

  Fly   740 ---QLNQCMDMYFSGERI------HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNS 795
               .:.:.:..:|:.|.|      .|:.|..|....:|:|...|.:.|..|:||||:|..:.::|
Yeast   582 RRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSS 646

  Fly   796 GSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYG-TMEGGHYTAFCKSANYGK 859
            ....:..:|..|    ||:..|   .||:.: |..|||.:|..|.| ::..|||.|.||..: |.
Yeast   647 SKMKQAVSYPMF----LDLTEY---CESKEL-PVKYQLLSVVVHEGRSLSSGHYIAHCKQPD-GS 702

  Fly   860 WFKFDDQVVSALDSSNVVSSA-AYILFYTWLPPMQVPL 896
            |..:||:.::.:...:|:... ||.|.||.|.|..|||
Yeast   703 WATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPL 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	10/42 (24%)
		Smc	<361..>511	CDD:440809	36/177 (20%)
		Peptidase_C19R	564..887	CDD:239139	101/406 (25%)
UBP10	NP_014213.2	PRK05901	28..>221	CDD:235640	41/208 (20%)
		UCH	362..730	CDD:425685	101/406 (25%)