Protein Alignment Usp8 and UBP12

DIOPT Version :9

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_012338.1
• Gene: UBP12 / 853242
• SGDID: S000003733
• Length: 1254
• Species: Saccharomyces cerevisiae
• Alignment Length: 1223
• Identity: 209/1223 - (17%)
• Similarity: 333/1223 - (27%)
• Gaps: 626/1223 - (51%)

  Fly   145 RLGLITCQDLYRRMQEKSVLVMDCRPSADYE-------ASHLTYYCAFNVPEELITPGMSAGRLQ 202
            |||:    ||...:.:|..:..:..|.:|.|       ||.::.:.:.|   |||....:|.  :
Yeast    30 RLGV----DLMNVLDDKDEIKQESVPVSDREIEDTESDASAVSSFASAN---ELIAEPHAAS--E 85

  Fly   203 ARLSSSAKASWASRSV----KDSVV-LMDWNTKDAQPATNTAISTLLDILKNWDPDVTYRAPI-- 260
            ..|.::.:   ..|:|    :|.|. |::.|.:..:......|...:...|.:|||||....|
Yeast    86 TNLGTNGQ---DGRNVLEQQRDVVARLIEENKETQKEGDKVCIVPKVWYDKFFDPDVTDPEDIGP 147

  Fly   261 ---QIVEGGYEYFIMMYPTHCTNPSVQAP------------------------QQNNNDIETIDD 298
               :::...:|.|::.....|...|:..|                        .|...::||..:
Yeast   148 INTRMICRDFENFVLEDYNRCPYLSIAEPVFNFLSEIYGMTSGSYPVVTNLVINQTTGELETEYN 212

  Fly   299 IEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQR 363
            ..:..:|.:|.|:|                    .|....|              ..|...:|..
Yeast   213 KWFFRLHYLTEKQD--------------------GRKRRHG--------------QDDSIMYLSM 243

  Fly   364 AEQN--DEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQE 426
            :..|  .:.:||:..::..:|...| :||.:     |:| ...|:..|...::|        :..
Yeast   244 SALNLVRDLVEKSMNLFFEKADHLD-VNAVD-----FKI-WFVSEGSDIATDSN--------VST 293

  Fly   427 LHNVTQQLSQKEVEATRNIESKIRE-------RQRLDEQHELERQERERLLAIARETKKHYKSPT 484
            ..|     |..|:...:.:|..|::       ..|||:                          .
Yeast   294 FLN-----SSYEITPLQFLELPIKKLLIPDMFENRLDK--------------------------I 327

  Fly   485 PSGPPSPGRNLEDVHVVSDSLESLLQLTGD---PDPTIAPNKAEIPTFDRAMKPQPRNVERTSQR 546
            .|.|             ||.:..:..:.|:   |....|.||.|           |.:
Yeast   328 TSNP-------------SDLVIEIKPIEGNHHWPSNYFAYNKLE-----------PAS------- 361

  Fly   547 VRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKT--NGQ 609
                          |.|||.||||||||||.||||.:.|||.:|.:.|.|::.|:..|..  :|.
Yeast   362 --------------GTTGLVNLGNTCYMNSALQCLVHIPQLRDYFLYDGYEDEINEENPLGYHGY 412

  Fly   610 VIEEVAALIKELWNGQYKCVASRDLRY-------VVGQYQKIFRGVDQQDSHEFLTILMDWLHSD 667
            |....:.|:::|:..:.. :..|:..:       .:|.:..:|.|..||||.|||..|:|.||.|
Yeast   413 VARAFSDLVQKLFQNRMS-IMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQEFLAFLLDSLHED 476

  Fly   668 LQTLHVPRQREMISAS---------------EKAWLEFTKAKESMILHLFYGQMKSTVKCVACHK 717
            |..:......|..|.|               :..|....|...|:|..||.|..|||:.|..|..
Yeast   477 LNRIIKKEYTEKPSLSPGDDVNDWNVVKKLADDTWEMHLKRNCSVITDLFVGMYKSTLYCPECQN 541

  Fly   718 ESATYESFSNLSLELP---------------------------------------------PN-- 735
            .|.|::.:::::|.||                                             ||
Yeast   542 VSITFDPYNDVTLPLPVDTVWDKTIKIFPMNSPPLLLEVELSKSSTYMDLKNYVGKMSGLDPNTL 606

  Fly   736 ----------------------------------------------------------------- 735
                                                                             
Yeast   607 FGCEIFSNQIYVNYESTESNAQFLTLQELIKPADDVIFYELPVTNDNEVIVPVLNTRIEKGYKNA 671

  Fly   736 ----------------------------------------------------------------- 735
                                                                             
Yeast   672 MLFGVPFFITLKEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPVGNRTDFADAFPLLVEKYPDVE 736

  Fly   736 -------------------------------------SN----------VCQLN----------- 742
                                                 ||          :.|||
Yeast   737 FEQYKDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNRTGPNFWTPISQLNLDKATDIDDKL 801

  Fly   743 --QCMDMY--------------------------------------------------------- 748
              ...|:|
Yeast   802 EDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVTNNENVNNTND 866

  Fly   749 -------------------------------------------------------------FSGE 752
                                                                         ||.:
Yeast   867 RDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTSTPFAILSMNDIIVCEWSELGSNEAFSDD 931

  Fly   753 RIHGWN-----------------------------------------------CPSCKTKRDAIK 770
            :|:.|.                                               ||:||..|.|.|
Yeast   932 KIYNWENPATLPNKELENAKLERSNAKERTITLDDCLQLFSKPEILGLTDSWYCPTCKEHRQATK 996

  Fly   771 KLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPK--TYQL 833
            ::.:...|.:|::|||||.:..|.|.   |....:.||:.:||::.|:...:.    |:  .|.|
Yeast   997 QIQLWNTPDILLIHLKRFESQRSFSD---KIDATVNFPITDLDLSRYVVYKDD----PRGLIYDL 1054

  Fly   834 YAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |||.||||.:.||||||:.|:....||:.|||..|:.....|.::.:||:|||
Yeast  1055 YAVDNHYGGLGGGHYTAYVKNFADNKWYYFDDSRVTETAPENSIAGSAYLLFY 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	30/146 (21%)
		UCH	562..886	CDD:278850	128/751 (17%)
		Peptidase_C19R	564..887	CDD:239139	129/751 (17%)
UBP12	NP_012338.1	UBP12	99..1111	CDD:227847	190/1142 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040