Protein Alignment Usp8 and UBP6

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_116665.1
• Gene: UBP6 / 850562
• SGDID: S000001906
• Length: 499
• Species: Saccharomyces cerevisiae
• Alignment Length: 552
• Identity: 121/552 - (21%)
• Similarity: 180/552 - (32%)
• Gaps: 216/552 - (39%)

  Fly   463 RQERERLLAIARETKKHYKSPTPSGPPS--------PGRNLEDVHVVSDSLESLLQLTGDPDPTI 519
            :.:.|.|..:....:|:......||..|        ||              |.:.|.|.||..:
Yeast    31 KSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPG--------------STVMLLGTPDANL 81

  Fly   520 APNKAEIPTFDRAMKPQPRNVERTSQRVRDFS--PVIGQNVGRGLTGLKNLGNTCYMNSILQCLS 582
            ....|:...|...:.|:        |:|:.|:  ||          |.||:|||||:|:.||.|.
Yeast    82 ISKPAKKNNFIEDLAPE--------QQVQQFAQLPV----------GFKNMGNTCYLNATLQALY 128

  Fly   583 NTPQLTE----YCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCV-------------- 629
            ....|.:    |..|....|..::..:.:.|::.|:....:.|.|..:|.|
Yeast   129 RVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYP 193

  Fly   630 --ASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTK 692
              |.||.:   |.:.|      |||:.|..|.|   .||
Yeast   194 QFAERDSQ---GGFYK------QQDAEELFTQL---FHS-------------------------- 220

  Fly   693 AKESMILHLFYG---------QMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMY 748
                  :.:.:|         |.|:|:|..|...:....|:.|:..|:       |.::...:..
Yeast   221 ------MSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQ-------CHISGTTNFM 272

  Fly   749 FSGERIHGWN----CPSCKTKRDAIKKLD--ISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLR- 806
            .:| .:.|.|    ..|..|..::|..::  ||:||..|.|...||:...|.:    ||...||
Yeast   273 RNG-LLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTN----KKSKILRK 332

  Fly   807 ----FPLENLDM-NPYIA------RAESRAV-------------------------TPK------ 829
                |.|:..|| .|..|      |.|.|.|                         ||:
Yeast   333 VVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPREQYETQ 397

  Fly   830 -------------------------------TYQLYAVSNHYG-TMEGGHYTAFCK-SANYGKWF 861
                                           .|.|..|..|.| ..|.|||.||.: ..:..||:
Yeast   398 VALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWY 462

  Fly   862 KFDDQVVSALDSSNVVSSA-------AYILFY 886
            ||:|..||.::...:.|.|       |.||.|
Yeast   463 KFNDDKVSVVEKEKIESLAGGGESDSALILMY 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809	9/55 (16%)
		Peptidase_C19R	564..887	CDD:239139	100/441 (23%)
UBP6	NP_116665.1	Ubl1_cv_Nsp3_N-like	5..78	CDD:475130	11/60 (18%)
		Peptidase_C19A	110..495	CDD:239122	100/441 (23%)