DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and USP32

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_011523673.1	Gene:	USP32 / 84669	HGNCID:	19143	Length:	1634	Species:	Homo sapiens

Alignment Length:	1346	Identity:	219/1346 - (16%)
Similarity:	357/1346 - (26%)	Gaps:	701/1346 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 RLGLITCQDLYRRMQEKSVLVMDCRPSADYEASHLTYYCAFNVPEELITPGMSAGRL-------Q 202
            ::|.:|.:| |:....|:||..:.. :..::..|:........|||       .|::       :
Human   346 KMGHLTLED-YQIWSVKNVLANEFL-NLLFQVCHIVLGLRPATPEE-------EGQIIRGWLERE 401

  Fly   203 ARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAISTLLDILKNWDPDVTYRA------PIQ 261
            :|....|..:|       .::.|.|                   .:.|...|.|.|      |..
Human   402 SRYGLQAGHNW-------FIISMQW-------------------WQQWKEYVKYDANPVVIEPSS 440

  Fly   262 IVEGG-YEYFIMMYPTHCTNPSVQAPQQNNNDIETIDD-----IEYPSIHDITMKEDISAKDFRP 320
            ::.|| |.:....:|                 :|.::|     :.|.:..:....::||
Human   441 VLNGGKYSFGTAAHP-----------------MEQVEDRIGSSLSYVNTTEEKFSDNIS------ 482

  Fly   321 RPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQR---AEQNDEQLEKASKMWKRQA 382
                      .|:..:|...|.....|.|.|::.     |.::   ::.|::.|         ..
Human   483 ----------TASEASETAGSGFLYSATPGADVC-----FARQHNTSDNNNQCL---------LG 523

  Fly   383 AEGDGL--------NATEDQELHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEV 439
            |.|:.|        .|.::|.|   :.|...||....:|..||:.   ..|.:|....::..:.|
Human   524 ANGNILLHLNPQKPGAIDNQPL---VTQEPVKATSLTLEGGRLKR---TPQLIHGRDYEMVPEPV 582

  Fly   440 ----------------EATRNIESKIRERQR-------LDEQHELERQERERLLAIARETKKHYK 481
                            ...:|.::.|.|.:.       |.:|.....|:....:.:...:.:.:.
Human   583 WRALYHWYGANLALPRPVIKNSKTDIPELELFPRYLLFLRQQPATRTQQSNIWVNMGMMSLRMFP 647

  Fly   482 SPTPSG-PPSPGRNL-------------------------------EDVHVVSDSLESLLQLTGD 514
            ...|.| .|||...|                               ||:.:...:.|:.|.|..|
Human   648 QHLPRGNVPSPNAPLKRVLAYTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDD 712

  Fly   515 PDPTIAPNK--------AEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNT 571
            .|..:...|        .|:...|.:...:...:..:|:..|...|     ..:|.|||.|||||
Human   713 EDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFIANSSKIDRHKVP-----TEKGATGLSNLGNT 772

  Fly   572 CYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDL 634
            |:|||.:||:|||..||:|.||.::...::|:|.  ..|.:.:....|::|||:|..|.||...|
Human   773 CFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKL 837

  Fly   635 RYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISA--------SEKAWLEFT 691
            |:.:.:|...|.|..||||.|.|..|:|.||.||..:|.....|:..:        :.:||....
Human   838 RWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHL 902

  Fly   692 KAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPN--------------------- 735
            :...|:::.||:||::|.|||..|...|..::.|:.|||.||.:
Human   903 RRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYG 967

  Fly   736 ----------------SNVCQLNQ----------------------------------------- 743
                            |::|.||.
Human   968 LRLNMDEKYTGLKKQLSDLCGLNSEQILLAEVHGSNIKNFPQDNQKVRLSVSGFLCAFEIPVPVS 1032

  Fly   744 ----------------------------------------------------------------- 743

Human  1033 PISASSPTQTDFSSSPSTNEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSL 1097

  Fly   744 -----------------------------------------C------MDMY------------- 748
                                                     |      .|:|
Human  1098 PDSPFTGYIIAVHRKMMRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASP 1162

  Fly   749 ----------------------------------------------------------------- 748

Human  1163 LPPQEASNHAQDCDDSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAV 1227

  Fly   749 --------------------------------------------FSGERIHGWN----CPSCKTK 765
                                                        |:.|...|.|    |..|||.
Human  1228 DWDPTALHLRYQTSQERVVDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTH 1292

  Fly   766 RDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPY------------- 817
            ..|.||||:.:|||:|::|||||   ...:|.::|.|..::||.|:.|.:.:
Human  1293 CLATKKLDLWRLPPILIIHLKRF---QFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALCQHKP 1354

  Fly   818 -------------IAR------AESRA-------------------------------------- 825
                         :||      |:|.|
Human  1355 LTPQGDELSEPRILAREVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSSRKSGTSCPS 1419

  Fly   826 ----------------------------------------------------------------- 825

Human  1420 SKNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICELADALSRGHVLGGS 1484

  Fly   826 ----VTPK----------------------------------------------TYQLYAVSNHY 840
                |||:                                              .|.|||:|.|.
Human  1485 QPELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQREDTRIKPIYNLYAISCHS 1549

  Fly   841 GTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |.:.||||..:.|:.|. ||:.::|.....|....:.:.:||||||
Human  1550 GILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFY 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	25/143 (17%)
		UCH	562..886	CDD:278850	136/834 (16%)
		Peptidase_C19R	564..887	CDD:239139	137/834 (16%)
USP32	XP_011523673.1	EF-hand_7	252..309	CDD:290234
		EFh	253..309	CDD:238008
		EF-hand_7	286..358	CDD:290234	4/12 (33%)
		UBP12	534..1346	CDD:227847	145/825 (18%)
		DUSP	<535..602	CDD:283896	12/72 (17%)
		Ubiquitin_3	653..740	CDD:291502	15/86 (17%)
		Peptidase_C19	765..>955	CDD:271592	70/189 (37%)
		Peptidase_C19	<1255..1595	CDD:271592	60/344 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940