Protein Alignment Usp8 and Usp8

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001239509.1
• Gene: Usp8 / 84092
• MGIID: 1934029
• Length: 1091
• Species: Mus musculus
• Alignment Length: 1116
• Identity: 333/1116 - (29%)
• Similarity: 498/1116 - (44%)
• Gaps: 269/1116 - (24%)

  Fly     5 KKLHMSSNLDDL-EKMSIIPDLRS-KGMKI--------LLNTARKLYMTAEEYRLDGDEELAYIT 59
            |:|::||:|.|| :|..:.|:..| |..|.        .:::|:|::.||||.|||.|||.||:.
Mouse     9 KELYLSSSLKDLNKKTEVKPEKTSTKNTKFCKFSSFLSYIHSAQKIFKTAEECRLDRDEERAYVL 73

  Fly    60 YMKYFNMLTAIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLRHRY------------- 111
            ||||..:...|.|:.|:...:.....:||.....:.| :..|.:..||:.||
Mouse    74 YMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAI-EEAERLSESLKLRYEEAEVRKQLEEKD 137

  Fly   112 ------AQQHQAPEPIAPDLVSNGRAGVDSPITQPTQYARL-------------GLITCQDLYRR 157
                  .||.:..|....|..:..:..|::.:...|:..|:             |.||.::||..
Mouse   138 RREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKTQRINGEKSEGAAAAERGAITAKELYTM 202

  Fly   158 MQEK--SVLVMDCRPSADYEASHLTYYCAFNVPEELITPGMSAGRLQARLSSSAKASWASRSVKD 220
            |.:|  |:::||.|...||:  |.....:.:||||.|:||::|..::|.||..:|.:|..|...|
Mouse   203 MMDKNTSLIIMDARKIQDYQ--HSCILDSLSVPEEAISPGVTASWIEANLSDDSKDTWKKRGSVD 265

  Fly   221 SVVLMDWNTKDAQPATNTAISTLLDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQA 285
            .|||:||.:........|.:.:|.|.|..|:.....|....::|||||.:::.||...||..|..
Mouse   266 YVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKTVLRHEPLVLEGGYENWLLCYPQFTTNAKVTP 330

  Fly   286 PQQNN-NDIETIDDIEYPSIHDITMKEDISAK---DFRPRP-DFNR------------------- 326
            |.::. .::....|..|||     ::|.:.:|   ...|.| :.|.
Mouse   331 PPRSRAEEVSVSLDFTYPS-----LEEPVPSKLPTQMPPPPIETNEKALLVTDQDEKLRLSTQPA 390

  Fly   327 -ANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAE------QNDEQL------------- 371
             |...||.|.....|.:|:|..|.:.::.|.:...::..|      :|.:|.
Mouse   391 LAGPGAAPRAEASPIIQPAPATKSVPQVDRTKKPSVKLPEDHRIKSENTDQSGRVLSDRSTKPVF 455

  Fly   372 ----------EKA----------------SKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDY 410
                      |||                .::|.:|..|.......|:||      :...|.||
Mouse   456 PSPTTMLTDEEKARIHQETALLMEKNKQEKELWDKQQKEQKEKLRREEQE------RKAGKTQD- 513

  Fly   411 IVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKI----------RERQRLDEQHELE--- 462
                   .:|....:..|.......:|:.:.|:..:.::          .:||...| ||..
Mouse   514 -------ADERDSTENQHKAKDGQEKKDSKQTKTEDRELSADGAQEATGTQRQSKSE-HEASDAK 570

  Fly   463 --------------------------------RQERERLLAIARE-------------------- 475
                                            :.:||.|.....|
Mouse   571 VPVEGKRCPTSEAQKRPADVSPASVSGELNAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPI 635

  Fly   476 --TKKHYKSPT----------------PSGPPSPGRNLEDVHVVSDSL--------ESLLQLTGD 514
              |.::|.|||                ||.||:        |.|...:        ..|.:....
Mouse   636 TGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPT--------HKVKPQVPAERDREPSKLKRSYSS 692

  Fly   515 PDPTIAPNKAE------IPTFDRAMKP--QPR-NVERTS-QRVRDFSPVIGQNVGRGLTGLKNLG 569
            ||.|.|..:.|      .|..:|..||  .|: .:.|.| .::|:.:||.|.: |..||||:|||
Mouse   693 PDITQALQEEEKRRPAVTPMVNRENKPPCYPKAEISRLSASQIRNLNPVFGGS-GPALTGLRNLG 756

  Fly   570 NTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKT--NGQVIEEVAALIKELWNGQYKCVASR 632
            ||||||||||||.|.|.|.:|...:.|::.|:|||..  .|:|.||...::|.||.|||:.::.:
Mouse   757 NTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPK 821

  Fly   633 DLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDL-----QTLHVPRQREM---ISASEKAWLE 689
            |.:..:|:....|.|..||||.|.|..|||.||.||     :..|.....|.   :.|:|.||.:
Mouse   822 DFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNEHLDDLQAAEHAWQK 886

  Fly   690 FTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERI 754
            ..:..||:|:.||.||.||||:|:.|.:.|.|:|:|..|||.|...|. |.|..|:.::...|::
Mouse   887 HKQLNESIIVALFQGQFKSTVQCLTCRRRSRTFEAFMYLSLPLASTSK-CTLQDCLRLFSKEEKL 950

  Fly   755 HGWN---CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKK-QNYLRFPLENLDMN 815
            ...|   |..|:.:||::||::|.||||||:||||||    |..|.:.:| |..:.|||||||::
Mouse   951 TDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRF----SYDGRWKQKLQTSVDFPLENLDLS 1011

  Fly   816 PYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSA 880
            .|:...::   :.|.|.|::||||||.::||||||:||:|...:||||||..||.:..|:|.|||
Mouse  1012 QYVIGPKN---SLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSA 1073

  Fly   881 AYILFYTWLPP 891
            |||||||.|.|
Mouse  1074 AYILFYTSLGP 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647	41/137 (30%)
		RHOD	148..278	CDD:444705	46/131 (35%)
		Smc	<361..>511	CDD:440809	40/285 (14%)
		Peptidase_C19R	564..887	CDD:239139	153/336 (46%)
Usp8	NP_001239509.1	USP8_dimer	6..127	CDD:462647	44/146 (30%)
		Radial_spoke_3	<91..>171	CDD:461827	23/113 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..187		17/71 (24%)
		Rhodanese	204..315	CDD:425764	33/111 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..466		15/85 (18%)
		SH3-binding	416..424		0/7 (0%)
		PTZ00121	<464..589	CDD:173412	54/215 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	479..616		60/194 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..721		32/75 (43%)
		UCH	750..1079	CDD:425685	73/150 (49%)