Protein Alignment Usp8 and USP26

DIOPT Version :9

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_114113.1
• Gene: USP26 / 83844
• HGNCID: 13485
• Length: 913
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 114/533 - (21%)
• Similarity: 214/533 - (40%)
• Gaps: 123/533 - (23%)

  Fly   386 DGLNATEDQELHF---RILQLESK-----AQDYIVENNRLREELSRIQELHNVTQQLSQKEVEAT 442
            :||::|:.::|..   |:.|.|.:     .:...|.::..::|::: ...|.|.::.|.|..|..
Human    84 EGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFSSTTQKEINK-TSFHKVDEKSSSKSFEIA 147

  Fly   443 RNIESKIRERQRL---------DEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDV 498
            :...:.:.:|..|         .|..|.:.::|:|:|:.:.|..:.:.....|......: .:..
Human   148 KGSGTGVLQRMPLLTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSK-ADCS 211

  Fly   499 HVVSDSLESLLQLTG-------DPDPTIAPNKAEIPTFD-----RAMKPQPRNVERTSQRVRDFS 551
            ..||.:.|..|:|..       :.:.:...|....|..|     :|:         |.:.|..|
Human   212 RCVSYNREKQLKLKELEENKKLECESSCIMNATGNPYLDDIGLLQAL---------TEKMVLVF- 266

  Fly   552 PVIGQNVGRGLT------------------GLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYK- 597
             ::.|....|.|                  ||.|||||||||::||.|.:.|...:..::..:.
Human   267 -LLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPW 330

  Fly   598 -----NYISRSNKTNGQVIEEVAALI--KELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHE 655
                 |.::..          :|.|:  |:.:|.:.|.:...:|:..:....:||.|..|.|:||
Human   331 GKIPLNALTMC----------LARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHE 385

  Fly   656 FLTILMDWLHSDLQTLHV-------------PRQREMISASEKAWLEFTKAKESMILHLFYGQMK 707
            ||...:|.|..:::.|:.             |:|   :.|.:..    |......::..|..::.
Human   386 FLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQ---VFADDPD----TSGFSCPVITNFELELL 443

  Fly   708 STVKCVACHKESATYESFSNLSLELP------PNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKR 766
            .::.|.||.:.....|..:.||:.||      |:|    :....|::|..|.:. :.|..|:.|
Human   444 HSIACKACGQVILKTELNNYLSINLPQRIKAHPSS----IQSTFDLFFGAEELE-YKCAKCEHK- 502

  Fly   767 DAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQN-------YLRFPLE-NLDMNPYIARAES 823
            .::.....|:||.:|:|||||:   ..|....:||.:       ||:.... |....|.:..:|.
Human   503 TSVGVHSFSRLPRILIVHLKRY---SLNEFCALKKNDQEVIISKYLKVSSHCNEGTRPPLPLSED 564

  Fly   824 RAVTPKTYQLYAV 836
            ..:|  .:||..|
Human   565 GEIT--DFQLLKV 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	77/328 (23%)
		Peptidase_C19R	564..887	CDD:239139	76/308 (25%)
USP26	NP_114113.1	UCH_N	3..103	CDD:293279	5/18 (28%)
		UCH	296..>559	CDD:278850	71/288 (25%)
		Peptidase_C19	296..>558	CDD:239072	70/287 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..636
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..772
		Peptidase_C19	<802..884	CDD:239072

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810