DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and UBP21

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_568667.1	Gene:	UBP21 / 834717	AraportID:	AT5G46740	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	532	Identity:	141/532 - (26%)
Similarity:	220/532 - (41%)	Gaps:	139/532 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 IVENNRLREELSRIQELHN-VTQQLSQKEVEATRNIESKIRERQRL-------------DEQHEL 461
            :.:.|:..:|.|....:.: ||..||         :.|.||:.|.|             |:....
plant    18 LTKPNQTLDESSPTAPIRDLVTNSLS---------LSSPIRQIQALSPAKPDGSSSSPPDKTLNF 73

  Fly   462 ERQERERLLAIARETKKHYKSPTPS-----GPP---SPGRNLEDVHVVSDSLESL-------LQL 511
            ..:|.       |:......|.:||     .||   ||..|...:.:.:.|...|       ::.
plant    74 NPEEN-------RDVNPDESSSSPSDKTLIAPPAQISPVSNNNHLRITNTSDSYLYRPPRRYIEY 131

  Fly   512 TGDPDPTIAPNKAEIPTFDRAMKP------QPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGN 570
            ..|.|..   ||.| ||     ||      .|| :|.|             .||   .||.|.||
plant   132 ESDDDEL---NKME-PT-----KPLQLSWWYPR-IEPT-------------GVG---AGLYNSGN 170

  Fly   571 TCYMNSILQCLSNTPQLTE-----------------YCISDKYKNYISRSNKTNGQVIEEVAALI 618
            ||::.|:|||.::|..|.:                 :|:....:::|..:.:::|..|.     |
plant   171 TCFIASVLQCFTHTVPLIDSLRSFMYGNPCNCGNEKFCVMQALRDHIELALRSSGYGIN-----I 230

  Fly   619 KELWNGQYKCVASRD-LRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISA 682
            ...          || |.|    :...|....|:|:||||...:|.|  :...|....|...:|:
plant   231 DRF----------RDNLTY----FSSDFMINHQEDAHEFLQSFLDKL--ERCCLDPKNQLGSVSS 279

  Fly   683 SEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDM 747
            .:.          :::.::|.|.:.||:.|..|:..|.|:|.....|||:   .:|..|.:.::.
plant   280 QDL----------NIVDNVFGGGLMSTLCCCNCNSVSNTFEPSLGWSLEI---EDVNTLWKALES 331

  Fly   748 YFSGERIHG-WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKK-QNYLRFPLE 810
            :...|::.. ..|.:||.|....|:|...|||||...|||||    :|.|..|:| .:::.||||
plant   332 FTCVEKLEDQLTCDNCKEKVTKEKQLRFDKLPPVATFHLKRF----TNDGVTMEKIFDHIEFPLE 392

  Fly   811 NLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEG-GHYTAFCKSANYGKWFKFDDQVVSALDSS 874
             ||::|:::......|:.: |.|||...|.|.... |||:::.:||. ..|..|||..|:.:...
plant   393 -LDLSPFMSSNHDPEVSTR-YHLYAFVEHIGIRATFGHYSSYVRSAP-ETWHNFDDSKVTRISEE 454

  Fly   875 NVVSSAAYILFY 886
            .|:|..||||||
plant   455 RVLSRPAYILFY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	99/344 (29%)
		Peptidase_C19R	564..887	CDD:239139	101/344 (29%)
UBP21	NP_568667.1	Peptidase_C19E	162..467	CDD:239126	102/349 (29%)
UBP21	NP_568667.1	UCH	163..466	CDD:278850	99/343 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920