DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and UBP16

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_567705.1	Gene:	UBP16 / 828558	AraportID:	AT4G24560	Length:	1008	Species:	Arabidopsis thaliana

Alignment Length:	776	Identity:	175/776 - (22%)
Similarity:	304/776 - (39%)	Gaps:	180/776 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 EELITPGMSAGRLQARLSSSAK----------ASWASRSVKDSVVLMDWNTKDAQPATNTAISTL 243
            ||.::...::|...:..|||.:          .|::|...:.|..|:|.:. ..:| .:|..||:
plant   184 EEAVSVAETSGSSFSGFSSSPRNDSGDEISRCESFSSSESERSESLLDAHV-SVEP-EDTCFSTI 246

  Fly   244 LDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNP--SVQAPQQNNNDIETIDDIEYPSIHD 306
            .|            ||.:::...:.:.:.........|  ||..|:.:....::    :..|:|.
plant   247 ED------------APSKLLSPKFVHLVESVDNLANLPKLSVHKPEDDAGQNQS----QSRSLHS 295

  Fly   307 -ITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQ 370
             :|.:..:||.......||......:|.||::..:.  |...:|
plant   296 LVTDRHPVSADPSLKSSDFWGTALGSAERVSDSCVK--SKSGRP--------------------- 337

  Fly   371 LEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLRE-ELSRIQE------LH 428
             ..:|..:...:......:|.:..|....||:...:...||.:...||| ...|..|      :.
plant   338 -GNSSLHFSFGSGSSRDTSAAKVSEQRSSILKEAPRGTGYISDGVNLRERNAKRFDEAEIALPIS 401

  Fly   429 NVTQQLSQKEVEATRNI---ESKIRERQRLDEQHELERQERERLLAIARETKK--HYKSPTPSGP 488
            :.|..||..:.....::   :||....:.......|:..|.:.|.:.|..|||  .....:|.|.
plant   402 SSTDALSPLDSSNLSHVTLPKSKSASSENGSMLAPLKVGEVQLLASKASNTKKCADLMKHSPLGA 466

  Fly   489 PSPG------------RNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVE 541
            .|..            :::..:|..|....|:|::.                 |:..:|:..|
plant   467 KSVRVLDHQKQNGAVVQHINSLHGRSGLKASVLKVV-----------------DQWTRPKSEN-- 512

  Fly   542 RTSQRVRDFSPVIGQNVGRGL------------------TGLKNLGNTCYMNSILQCLSNTPQLT 588
                      .:.|::..:||                  .||.|:||:|:.|.:.|||..||.||
plant   513 ----------EMAGRHGHKGLFPYEVFAKLYTYKIEFQPCGLINVGNSCFANVVFQCLMFTPPLT 567

  Fly   589 EYCISDKYKNYISRSNKTNGQVIEEVAALIKE-----LWNGQYKCVASRDLRYVVGQYQK--IFR 646
            .|.:...:....::..:......|::....||     ..||            ::.|.|.  ||.
plant   568 TYFLQQFHSRACTKKEQCFTCGFEKLVVKAKEEKSPLSPNG------------LLSQLQNIGIFL 620

  Fly   647 G-VDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHL-FYGQMKST 709
            | ..::|:||||..::|.:           |...|.|||....:.:|.:::.::.| |.|.::|.
plant   621 GNGKEEDAHEFLRFVVDTM-----------QSVCIKASEYDMTKSSKLEDTTLIGLTFGGYLRSK 674

  Fly   710 VKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWN---CPSCKTKRDAIKK 771
            :||:.|..:|...|...:|::|:  :.::..|:..:..:...|.:.|.|   |.|||:...|.||
plant   675 IKCMKCQVKSELREKMMDLTVEI--DGDISTLDDALRRFTRTEILDGENKYRCGSCKSYERAKKK 737

  Fly   772 LDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAV 836
            |.|::.|.||.:.||||.|     |.:.|....:||| |.||:.||::....::   ..|:||.|
plant   738 LKITEPPNVLTIALKRFQA-----GKFGKLNKLIRFP-ETLDLAPYVSGGSEKS---HDYKLYGV 793

  Fly   837 SNHYGTME---GGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY---TWLPP 891
            ..|...|.   .|||..:.::.|  ||:|.||..|...|...:::..||:|||   |..||
plant   794 IVHLDVMNAAFSGHYVCYIRNQN--KWYKADDSTVVTSDVERILTKGAYMLFYARCTPTPP 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	18/98 (18%)
		UCH	562..886	CDD:278850	100/356 (28%)
		Peptidase_C19R	564..887	CDD:239139	101/340 (30%)
UBP16	NP_567705.1	zf-MYND	74..111	CDD:396356
UBP16	NP_567705.1	Peptidase_C19	541..845	CDD:351799	100/339 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920