DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and USP11

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001358001.1	Gene:	USP11 / 8237	HGNCID:	12609	Length:	920	Species:	Homo sapiens

Alignment Length:	925	Identity:	190/925 - (20%)
Similarity:	295/925 - (31%)	Gaps:	411/925 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 AATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKAS-------------------- 375
            |....|....:.....|..:.|....|.|.|...:....|:|...
Human     2 ATVAANPAAAAAAVAAAAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHW 66

  Fly   376 -KMWKRQAAEGD-------GL--NATEDQ-ELHFRILQLESKAQDYI---------------VEN 414
             |.|:.....||       |.  |||..| |:::|:.:...:.:||:               :|:
Human    67 YKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEH 131

  Fly   415 NRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELE-----------RQERER 468
            .:...| .::.||.|:      ::|| ...:|..:.....|.:.|.::           |..|||
Human   132 GQPPIE-RKVIELPNI------QKVE-VYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARER 188

  Fly   469 LLAIARE-TKKHYKSPTPSGPPSPGR--NLEDVH--VVSDSLES---LLQLTGDPDPTIAPNKAE 525
            .|...:| |:...|:       |.|.  .|.|.|  |:..:||:   ::..|...|.|..  .|:
Human   189 FLVEPQEDTRLWAKN-------SEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWP--SAQ 244

  Fly   526 IPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEY 590
            :...:..|          |:...||.   ||   .|:.||.||||||:|||.||||||.||||||
Human   245 LHVMNNNM----------SEEDEDFK---GQ---PGICGLTNLGNTCFMNSALQCLSNVPQLTEY 293

  Fly   591 CISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDS 653
            .:::.|...::..|.  ..|::.|..|.|:|:.|:|.::.:.....:..||.:...|.|..|.||
Human   294 FLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDS 358

  Fly   654 HEFLTILMDWLHSDLQTLHVPRQREMISA--------SEKAWLEFTKAKESMILHLFYGQMKSTV 710
            .|.|:.|:|.||.||..:......|:..|        :::||....:..:|:|:..|:|..|||:
Human   359 QELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTL 423

  Fly   711 KCVACHKESATYESFSNLSLELP------------------------------------------ 733
            .|..|...|.|::.|..||:.||
Human   424 VCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSK 488

  Fly   734 ----------------------------------------------------------------- 733

Human   489 HTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRE 553

  Fly   734 -------------------------------------------------PNS------------- 736
                                                             |||
Human   554 RTPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDE 618

  Fly   737 ------------------------------NVC-------------------------------- 739
                                          |.|
Human   619 EDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNG 683

  Fly   740 -----------------------------------------------------QLNQCMDMYFSG 751
                                                                 :|.:|::::.:.
Human   684 TSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTV 748

  Fly   752 ERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM-----KKQNYLRFP 808
            |.:   :.|.|||||..:.|.||||:..||.:|::|||||        ||.     |....:.||
Human   749 ETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRF--------SYTKFSREKLDTLVEFP 805

  Fly   809 LENLDMNPYIARAESRAVTPKTYQ--LYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSAL 871
            :.:||.:.::.:.::.: .|:.|:  |.|||||||.|..||||.|..:.:.|:|..|||..||.:
Human   806 IRDLDFSEFVIQPQNES-NPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPV 869

  Fly   872 DSSNVVSSAAYILFY 886
            :.:.:.|.|||:|||
Human   870 NENQIESKAAYVLFY 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	129/627 (21%)
		Peptidase_C19R	564..887	CDD:239139	131/627 (21%)
USP11	NP_001358001.1	UBP12	56..886	CDD:227847	181/871 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940