DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and UBP5

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001323724.1	Gene:	UBP5 / 818691	AraportID:	AT2G40930	Length:	924	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	190/998 - (19%)
Similarity:	313/998 - (31%)	Gaps:	437/998 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 VKDSVVLMDWNTKDAQPATNTAISTLLDILKNWDPD----VTYRAPIQIVEGGYEYFIMMYPTHC 278
            ::|..:..:.|:|:.        .|...|.:.|..:    |....|....:|.      ....||
plant    24 IRDIAIAAEANSKEG--------DTFYLITQRWWQEWIEYVNQDQPCNTNDGS------SLSEHC 74

  Fly   279 TNP---SVQAPQQ-NNNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQG 339
            .:|   :::.|.: :|:|:          |:|.::::
plant    75 DSPGSSTLKKPSRIDNSDL----------IYDSSLED---------------------------- 101

  Fly   340 ISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKR-QAAEGDGLNATEDQELHFRILQL 403
               ||           :.:|.::..::..:.:....::|.: ::..|.|      ..|..|::..
plant   102 ---PS-----------NTSEIIETLQEGRDYVLLPQEVWNQLRSWYGGG------PTLARRVISS 146

  Fly   404 ESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQR-------LDEQH-- 459
            .....:..||...||.:|..:.:..:...::|:||.         |||..|       ||.:|
plant   147 GLSQTELAVEVYPLRLQLLLMPKSDHSAIRISKKET---------IRELHRRACEIFDLDSEHVR 202

  Fly   460 --ELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDS--LESLLQLTG------- 513
              :....::..|:....:|                  |:|.::..|.  |..:|.:.|
plant   203 IWDYYGHQKYSLMNDLDKT------------------LDDANLQMDQDILVEVLDINGTLSSAHI 249

  Fly   514 ---------DPDPT---IAPNKAEI------PTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGR 560
                     |.|.|   |.|:|:.:      .:...|.:.....|.::.......:.|..:....
plant   250 QSAQENGLVDGDSTSILIEPSKSSLAAAGGFSSSRNAFRTGSVEVSQSFDNTYSSTGVTTRGSTA 314

  Fly   561 GLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTN--GQVIEEVAALIKELWN 623
            |||||.||||||:|||.:|||.:||:...| ..:.|...|:..|...  |::......|:::||.
plant   315 GLTGLLNLGNTCFMNSAIQCLVHTPEFASY-FQEDYHQEINWQNPLGMVGELALAFGDLLRKLWA 378

  Fly   624 GQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTL-HVP---------RQRE 678
            .....:|.|..:..:.::...|.|.:|.||.|.|..|:|.||.||..: |.|         |..|
plant   379 PGRTPIAPRPFKAKLARFAPQFSGYNQHDSQELLAFLLDGLHEDLNRVKHKPYINSRDADGRPDE 443

  Fly   679 MISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPN-------- 735
            .:  :::.|.......:|:|:.:..||.|||:.|..|:|.|.|::.|..|||.|..|
plant   444 EV--ADEFWKNHIARNDSIIVDVCQGQYKSTLVCPICNKVSVTFDPFMYLSLPLQFNTTRAITVT 506

  Fly   736 ------------------------------SNVCQLNQCMDMYF--------------------- 749
                                          :|.|.|.|..::..
plant   507 VFSCDKTALPSTITVNVSKQGRCRDLIQALTNACSLKQSEELKLAEIRNNFIHRLFEDPLIPLSS 571

  Fly   750 --------------------------------SGER---------------------------IH 755
                                            :|||                           ||
plant   572 IKDDDHLAAYKLSKSSENTTLLRLVLRRRDQKAGERESTVQLKPCGTPLLSSASCGDALTKGKIH 636

  Fly   756 ----------------------------------------------------------------- 755

plant   637 CLVQNMLSPFRREESVGKKGNSDSSIPERRSARFNNTEEEDKVGGLKKAKKSNSSDLGASKLSLQ 701

  Fly   756 ----------------------------------------------------------------- 755

plant   702 LIDEDNKTINLPDNEAEAMKLPSSATVTIYLDWTPELSGMYDITCLESLPEVLKYGPTTKKARSE 766

  Fly   756 ---------------------GWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM 799
                                 .|.||.|..:|.|.||||:.:||.|||:|||||    |.|.|..
plant   767 PLSLYACLEAFLREEPLVPDEMWFCPQCNERRQASKKLDLWRLPEVLVIHLKRF----SYSRSMK 827

  Fly   800 KK-QNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKF 863
            .| :.::.||:.:||:..|:  |......|:.|:|||::||||.|..|||||..|..:..:|:.|
plant   828 HKLETFVNFPIHDLDLTKYV--ANKNLSQPQLYELYALTNHYGGMGSGHYTAHIKLLDDSRWYNF 890

  Fly   864 DDQVVSALDSSNVVSSAAYILFY 886
            ||..:|.::..:|.|.|||:|||
plant   891 DDSHISHINEDDVKSGAAYVLFY 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	9/63 (14%)
		UCH	562..886	CDD:278850	130/605 (21%)
		Peptidase_C19R	564..887	CDD:239139	130/605 (21%)
UBP5	NP_001323724.1	UBP12	32..917	CDD:227847	189/990 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010