DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and UBP19

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_565576.1	Gene:	UBP19 / 817000	AraportID:	AT2G24640	Length:	672	Species:	Arabidopsis thaliana

Alignment Length:	360	Identity:	91/360 - (25%)
Similarity:	154/360 - (42%)	Gaps:	84/360 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 GLKNLGNTCYMNSILQCLSNTPQLTEY---------------CISDKYKNYISRSNKTN-----G 608
            ||.|.||:|:.|.:|||||.|..|..|               |...:::|::.|:|.:.     .
plant   175 GLTNCGNSCFANVVLQCLSWTRPLVAYLLERGHKRECRRNDWCFLCEFENHLDRANYSRFPFSPM 239

  Fly   609 QVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDL----- 668
            .:|..:..:...|..|:                        |:|:||.:...:|.:.|..
plant   240 NIISRLPNIGGNLGYGR------------------------QEDAHELMRFAIDMMQSVCLDEFG 280

  Fly   669 -QTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLEL 732
             :.:..||.:|                .::|.::|.|.::|.|:|.||...|..||:..:|::|:
plant   281 GEKVVPPRAQE----------------TTLIQYIFGGLLQSQVQCTACSNVSDQYENMMDLTVEI 329

  Fly   733 PPNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSN 794
              :.:...|.:|:|.:.:.|.:.|   :.|..|.....|.|:|.|...|.:|.:.||||     .
plant   330 --HGDAVSLEECLDQFTAKEWLQGDNLYKCDRCDDYVKACKRLSIRCAPNILTIALKRF-----Q 387

  Fly   795 SGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEG---GHYTAFCKSAN 856
            .|.:.|....:.|| |..|:.||::.....:   ..|:||||..|...:..   |||..:.|...
plant   388 GGRFGKLNKRISFP-ETFDLGPYMSGGGEGS---DVYKLYAVIVHLDMLNASFFGHYICYVKDFR 448

  Fly   857 YGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPP 891
             |.|::.||..|..::..:|:|..||:|.|:.:.|
plant   449 -GNWYRIDDSEVEKVELEDVLSQRAYMLLYSRVQP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	89/353 (25%)
		Peptidase_C19R	564..887	CDD:239139	89/354 (25%)
UBP19	NP_565576.1	zf-MYND	64..101	CDD:280009
		Peptidase_C19E	173..478	CDD:239126	89/354 (25%)
		UCH	173..477	CDD:278850	89/353 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920