DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and Usp21

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_038947029.1	Gene:	Usp21 / 688466	RGDID:	1588822	Length:	619	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	146/552 - (26%)
Similarity:	226/552 - (40%)	Gaps:	155/552 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 RETKKHYKSPTPSG-------PPSPGRNLEDVHVVSDSLESL---------------------LQ 510
            |...|..::|.|..       ||.||       ...:.|:.|                     :.
  Rat    86 RARSKERRNPVPGPNSMLRPLPPRPG-------PPDERLKKLDLGRGRTSGSRPRGPLRADHGVP 143

  Fly   511 LTGDPDPTIA---PNKAEI----------------------------PTFDR-AMKPQPRNVER- 542
            |.|.|.||:|   |::..:                            ....| |::|:|..:.|
  Rat   144 LPGSPPPTVALPLPSRTNLTRSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRS 208

  Fly   543 TSQR-----------------------------VRDFSPVIGQN--------VGRGLTGLKNLGN 570
            ||.|                             .|...|....:        :|.|..||:||||
  Rat   209 TSLRRLGGFPGPPTLLSIRTEPPPSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGN 273

  Fly   571 TCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLR 635
            ||::|::|||||:|..|.::|:...::..:....:.. ::.|..|.:|..||:.. .|.|....|
  Rat   274 TCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQ-ELTEAFADVIGALWHPD-SCEAVNPTR 336

  Fly   636 Y--VVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQ-----------------------TLHVPR 675
            :  |..:|...|.|..|||:.|||.:||:.||.::.                       .||
  Rat   337 FRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPRRGGALH--- 398

  Fly   676 QREMISASEKA---WLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPN-- 735
            :...:|..::|   |..:.:.::|.|:.||.||:||.:||.||...|.|:|.|.:|||.:|..
  Rat   399 EEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 463

  Fly   736 -SNVCQLNQCMDMYFSGERIHGWN---CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSG 796
             .....|..|..::...|.:...|   |..|:.|..:.|||.:.:.|.:||:||.||   .::.|
  Rat   464 AGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF---STSRG 525

  Fly   797 SYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWF 861
            |..|....:.|||:.|.:..:   |..:..:| .|||||:.||.|::..|||||.|:...  .|.
  Rat   526 SIKKSSVGVDFPLQRLSLGDF---ASDKVGSP-VYQLYALCNHSGSVHYGHYTALCRCQT--GWH 584

  Fly   862 KFDDQVVSALDSSNVVSSAAYILFYTWL--PP 891
            .::|..||.:..:.|.||..|:|||..:  ||
  Rat   585 VYNDSRVSPVSENQVASSEGYVLFYQLMQEPP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	113/357 (32%)
		Peptidase_C19R	564..887	CDD:239139	114/356 (32%)
Usp21	XP_038947029.1	UCH	266..609	CDD:395355	113/356 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820