DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and USP17L3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001243800.1	Gene:	USP17L3 / 645836	HGNCID:	37175	Length:	530	Species:	Homo sapiens

Alignment Length:	433	Identity:	110/433 - (25%)
Similarity:	188/433 - (43%)	Gaps:	101/433 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 HYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERT 543
            |:...|.|.|              |:..:.:|.|..|:.:...::..:...| .:.|..|.:
Human    16 HFSKLTSSRP--------------DAAFAEIQRTSLPEKSPLSSETRVDLCD-DLAPVARQL--- 62

  Fly   544 SQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKN---------- 598
              ..|:..|:..:.......||:|:|||||.|:.||||:.|..|..|.:|.::..
Human    63 --APREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCML 125

  Fly   599 -----YISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLT 658
                 :|:.:..:.|.||:...||......|:                        |:|.||||.
Human   126 CTMQAHITWALHSPGHVIQPSQALASGFHRGK------------------------QEDVHEFLM 166

  Fly   659 ILMDWLHSDLQTLHVPRQREMISASEKAWLEFTK-----AKESMILH-LFYGQMKSTVKCVACHK 717
            ..:|                   |.:||.|...|     :|::.::| :|.|..:|.:||:.||.
Human   167 FTVD-------------------AMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHG 212

  Fly   718 ESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPP 779
            .|.|::.:.:::|::....:|   .|.::.....|.::|   ::|..|..:..|...|.:.....
Human   213 ISDTFDPYLDIALDIQAAQSV---KQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAK 274

  Fly   780 VLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYG-TM 843
            ||::.||||   ...:|:.:.|.  :::| |.|||.||:::..:   .|..|.||||..|.| :.
Human   275 VLILVLKRF---SDVAGNKLAKN--VQYP-ECLDMQPYMSQQNT---GPLVYVLYAVLVHAGWSC 330

  Fly   844 EGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            ..|||.::.| |..|:|:|.||..|:....::|:|..||:|||
Human   331 HDGHYFSYVK-AQEGQWYKMDDAEVTVCSITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	95/348 (27%)
		Peptidase_C19R	564..887	CDD:239139	97/348 (28%)
USP17L3	NP_001243800.1	Peptidase_C19E	79..373	CDD:239126	97/350 (28%)
		UCH	80..372	CDD:278850	95/347 (27%)
		HABP4_PAI-RBP1	<426..454	CDD:282609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920