Protein Alignment Usp8 and Usp51

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001131019.1
• Gene: Usp51 / 635253
• MGIID: 3588217
• Length: 661
• Species: Mus musculus
• Alignment Length: 739
• Identity: 160/739 - (21%)
• Similarity: 273/739 - (36%)
• Gaps: 233/739 - (31%)

  Fly   265 GGYEYFIMMYPTHC-TNPSVQAPQQNNNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRAN 328
            |.||..:...|..| |:.|...|::..                            ||||
Mouse    31 GSYEKVLPSIPAACHTSSSSVCPRRKP----------------------------RPRP------ 61

  Fly   329 KPAATRVNEQGI-SRPSPPAKP-----------------IA------------------EIMRDQ 357
            :|.:.....:|: :.|.|||||                 :|                  ....|.
Mouse    62 QPRSRSRGGRGLKAPPPPPAKPPPPPPAPPPPPLPKQRSVAWRNSRRRSRPGPRPQTRKSYSSDH 126

  Fly   358 AEFLQRAEQNDEQLE----------------KASKMWKR------QAAEGDGLNATEDQELHFRI 400
            ..........:..||                |.:|.|:|      |.....|...|..::....|
Mouse   127 GSSRDSDGSENSLLEVGSNKGPTGCCHVESFKVAKNWQRNLRMIYQRFIWSGTPETRKRKAKSCI 191

  Fly   401 LQLESKAQDYIVENNRLREELSRI---------------QELHNVTQQLSQ--------KEVEAT 442
            .|:.|      ...|||...||.:               ...||:...|..        ::....
Mouse   192 CQICS------THKNRLHSCLSCVFFGCFTDKHIHIHAETTQHNLAVDLCHGVIYCFMCRDYVYD 250

  Fly   443 RNIESKIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPS----PGRNLEDVHVVSD 503
            ::||             ::.::.:|::|.:.         .:|:|..|    ....:|:..:..:
Mouse   251 KDIE-------------KIAKETKEKILGLL---------SSPTGDASYQQLMASEVEENQLTCE 293

  Fly   504 SLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNL 568
            |.:....|                     :||:.:..::|.     :..|       |..||.||
Mouse   294 SKDQETSL---------------------VKPKKKRRKKTM-----YYTV-------GFRGLINL 325

  Fly   569 GNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRD 633
            ||||:||.|:|.|::.|.|.|:.:|:|:|..::..:..   ::.|::.|.:.:::|.........
Mouse   326 GNTCFMNCIVQVLTHIPLLKEFFLSNKHKCMMTSPSLC---LVCEMSLLFQAMYSGNQSPHIPYK 387

  Fly   634 LRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMI 698
            |.:::..:.:...|..|||:.|||..::|.||...:...:.::..            :.....:|
Mouse   388 LLHLIWIHAEHLAGYRQQDAQEFLIAILDVLHRHSRDDGIDQEGN------------SNCCNCII 440

  Fly   699 LHLFYGQMKSTVKCVACHKESATYESFSNLSLELP-----------------PNSNVCQLNQCMD 746
            .|:|.|.::|.:.|..||..|.|.:...::||:||                 ....|..|..|:.
Mouse   441 DHIFTGSLQSDLTCQVCHGVSTTIDPCWDISLDLPGPYTPGRASSSTSSRDGQKPRVISLTDCLK 505

  Fly   747 MYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQN-YLRF 807
            .:...|.:..   ..|..|::.:::.|:|.:.|||.|...|||||    .:.|...:|.| ::.|
Mouse   506 WFTRPEDLGSSAKIKCSQCQSYQESTKQLTMKKLPIVACFHLKRF----EHLGKQRRKINSFISF 566

  Fly   808 PLENLDMNPYIARAESRAV--TPKT--------YQLYAVSNHYGTMEGGHYTAFCKSANYGKWFK 862
            ||| |||.|::|..:...:  .|.|        |.|:||.||:||:|.||||:|.:... .:||.
Mouse   567 PLE-LDMTPFLASTKESIMKGQPLTECVPSENKYSLFAVINHHGTLESGHYTSFVRQEK-DQWFS 629

  Fly   863 FDDQVVSALDSSNVVSSAAYILFY 886
            .||.||:......:::|..|:|||
Mouse   630 CDDAVVTKATMEELLNSEGYLLFY 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	4/12 (33%)
		Smc	<361..>511	CDD:440809	29/198 (15%)
		Peptidase_C19R	564..887	CDD:239139	103/354 (29%)
Usp51	NP_001131019.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..144		24/146 (16%)
		zf-UBP	192..252	CDD:460464	10/65 (15%)
		Peptidase_C19D	320..654	CDD:239125	103/355 (29%)