DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and usp3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001186800.1	Gene:	usp3 / 569679	ZFINID:	ZDB-GENE-030131-5142	Length:	524	Species:	Danio rerio

Alignment Length:	399	Identity:	128/399 - (32%)
Similarity:	188/399 - (47%)	Gaps:	66/399 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 NVERTSQR--VRDFSP--VIGQNVGRGL----TGLKNLGNTCYMNSILQCLSNTPQLTEYCISDK 595
            |.:|..:|  ...|||  .:.|:....|    |||:||||||:||:|||.|||....:  |...:
Zfish   131 NTDRQRKRKMSESFSPDSKMKQDSEGALVQCATGLRNLGNTCFMNAILQSLSNIQVFS--CYFKE 193

  Fly   596 YKNYISRSNKTNGQ--------------VIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFR 646
            ..:...||.||.|:              ::||....:..||.|.....:...|.||:.:....||
Zfish   194 LPSVALRSGKTAGRRMYHTRSQGDSSVSLVEEFRKTLCSLWQGSQTAFSPDALFYVIWKIMPSFR 258

  Fly   647 GVDQQDSHEFLTILMDWLHSDLQ-----------TLHVPRQREMISASEKAWLEFTKAKESMILH 700
            |..|||:||||..|:|.||.::|           |...|..     |||...  |.....:::..
Zfish   259 GYQQQDAHEFLRYLLDHLHREMQGNKNGSPSPPVTSDEPNH-----ASESKC--FINGTSTIVTS 316

  Fly   701 LFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNV-----------CQLNQCMDMYFSGERI 754
            :|.|.:::.|.|:.|..||..::.|.:|||::|....:           |.|:.|:..:...|.:
Zfish   317 VFGGVLQNEVYCLICGTESRKFDPFLDLSLDIPNQFRIKTTKDQEPGPTCTLSDCLRSFTDLEEL 381

  Fly   755 HG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFY--ADPSNSGSYMKKQNYLRFPLENLDM 814
            ..   :.|..||.::.:.||..|.|||.||.:|||||:  |...|     |...|:.||:..|||
Zfish   382 DETELYMCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHWTAFLRN-----KVDTYVEFPMCGLDM 441

  Fly   815 NPYIARAESRAVTPKTYQLYAVSNHYGTMEG-GHYTAFCKSANYGKWFKFDDQVVSALDSSNVVS 878
            ..|:...|:.......|.|.||..|:|:..| |||||:  ..:.|:|:.|:|..|:.:....|:.
Zfish   442 KSYLLEPENSLPERCLYDLAAVVVHHGSGIGSGHYTAY--GRHEGQWYHFNDSTVTLVSEEAVLK 504

  Fly   879 SAAYILFYT 887
            :.|||||||
Zfish   505 AKAYILFYT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	118/369 (32%)
		Peptidase_C19R	564..887	CDD:239139	117/364 (32%)
usp3	NP_001186800.1	zf-UBP	29..109	CDD:280334
		UCH	162..512	CDD:278850	117/365 (32%)
		Peptidase_C19	164..513	CDD:271592	117/364 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920