DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and usp2a

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_005157570.1	Gene:	usp2a / 494031	ZFINID:	ZDB-GENE-041212-59	Length:	564	Species:	Danio rerio

Alignment Length:	369	Identity:	128/369 - (34%)
Similarity:	206/369 - (55%)	Gaps:	31/369 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 RNVERTSQRVRDFSPV---IGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNY 599
            ::..|.|...|..|||   :.....:||.||:||||||:|||||||||||..|.:||:.:.::..
Zfish   202 KSSSRFSSSYRSTSPVRESLNSKSAQGLVGLRNLGNTCFMNSILQCLSNTQSLRDYCLHNSHRRD 266

  Fly   600 ISRSNKTNGQVIEEVAALIKELW-NGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDW 663
            ::.:|:|:..::||.|.||:.:| :...:.|:..:.:..:.:|...|.|.:|||:.|||..|:|.
Zfish   267 LNNNNRTHTALMEEFAKLIQTMWTSSSSEAVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDG 331

  Fly   664 LHSDLQTL------------HVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACH 716
            ||:::..:            |:|.:.:    .:|.|.::.:.::|.|:.||.||:||::.|..|.
Zfish   332 LHNEVNRVTVRPRGNTEDFDHLPDEEK----GKKMWSKYLEREDSKIVDLFVGQLKSSLTCSECG 392

  Fly   717 KESATYESFSNLSLELPPNS-NVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKL 777
            ..|..::.|.:|||.:.... ....|..||.::...:.:.|   ..|..||.:|...||..:.|.
Zfish   393 YCSTVFDPFWDLSLPIAKKGYGEVSLMDCMRLFTKEDVLDGDEKPTCYRCKARRRCTKKFTVQKF 457

  Fly   778 PPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGT 842
            |.:||:|||||......:.   |...::.||:::||:..:.:...|.||    |.|||||||.||
Zfish   458 PKILVLHLKRFSEARIRTS---KLSTFVNFPMKDLDLREFASDRSSSAV----YNLYAVSNHSGT 515

  Fly   843 MEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            ..||||||:|.:...|:|:.::|..|:.:.:|.|.||.||:|||
Zfish   516 TMGGHYTAYCCNPENGEWYTYNDSRVTPMSASQVRSSDAYVLFY 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	119/340 (35%)
		Peptidase_C19R	564..887	CDD:239139	120/340 (35%)
usp2a	XP_005157570.1	UCH	230..559	CDD:306860	118/339 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750