Protein Alignment Usp8 and usp4

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: XP_002662556.2
• Gene: usp4 / 449927
• ZFINID: ZDB-GENE-041008-187
• Length: 1009
• Species: Danio rerio
• Alignment Length: 1063
• Identity: 212/1063 - (19%)
• Similarity: 319/1063 - (30%)
• Gaps: 511/1063 - (48%)

  Fly   229 TKDAQPATNT---AISTLLDIL---------------KNWDPDVTYRAPIQIVEGGYEYFIM--- 272
            |:...|:|.:   :|.|||..|               |.|...|           |::.:.:
Zfish    22 TQTPVPSTESQKQSIGTLLKTLLRKGDEWYLIDSRWFKQWKKYV-----------GFDSWDLYNV 75

  Fly   273 ----MYPTHCTNPSVQAPQQNNNDIE-TIDDIEYPSIHDITMKEDISAKDFRPRPDFNRA----- 327
                :||....|..:.:.:::.:..| .||:::|..:               |...:|:.
Zfish    76 GEHNLYPGPIDNSGLFSDRKSQSLKEHLIDELDYVLV---------------PTEAWNKLVSWYG 125

  Fly   328 ----NKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGL 388
                .||...:|.|.|:                   |::..:.....||               |
Zfish   126 SLGNQKPIIRKVVEHGM-------------------FVKHCKVEVYLLE---------------L 156

  Fly   389 NATEDQELHFRILQLESKAQDYIVENNRLREELSRIQ-ELHNVTQQLSQKEVEATRNIESKIRER 452
            |..|:..:...:.:..|||           :.:..|: |:.::....|:||........|...|:
Zfish   157 NLCENDNMDKVVTRHFSKA-----------DTIDTIEKEMRSLFDIPSEKETRLWNKYMSNTYEQ 210

  Fly   453 -QRLDEQHELERQERERLLAIARETKK--------HYKSPTPSG-----PPSPGRNLEDVHVVSD 503
             .:||...:.....:.::|.|.::.:.        |.||.|.:.     .|.|..|       |.
Zfish   211 LNKLDSTVQDAGLFQGQVLVIEKKNEDGTWPRQSCHSKSSTSTSRNYTTSPKPSSN-------SS 268

  Fly   504 SLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGR------GL 562
            :..|.....||.:    .|...:           .|...:..|:..::........|      ||
Zfish   269 ATISSTITNGDSN----SNSGYM-----------LNNSTSGNRLGSYNSYSSSYSYRESAAQPGL 318

  Fly   563 TGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQ 625
            .||.||||||:|||.||||||||.||||.:.|:|:..|:|.|.  ..|::.|..|.|:|::|..:
Zfish   319 CGLSNLGNTCFMNSALQCLSNTPPLTEYFLEDRYEAEINRENPLGMRGEIAEAYADLVKQMWLSR 383

  Fly   626 YKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVP----------RQREMI 680
            ...||.|..:..||::...|.|..||||.|.|..|:|.||.||..:...          |..|::
Zfish   384 SSYVAPRTFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLALRDAEGRPDEIV 448

  Fly   681 SASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP------------ 733
              :::||.......:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||
Zfish   449 --AKEAWANHRLRNDSIIVDIFHGLFKSTLVCPECSKVSVTFDPFCYLTLPLPMKKDRTMEVYLV 511

  Fly   734 ----------------------------------PNSNVC-----------------QLNQCMD- 746
                                              |:.|:.                 .|||.|:
Zfish   512 RTDPQFRAMQFRVVVPKMGAVADLCSALAKLSGVPSENMVVADVYNHRFHKIYKRDDGLNQIMEK 576

  Fly   747 -------------------MYF-----------SG---------------------------ERI 754
                               :||           ||                           |||
Zfish   577 DDIFVYEVLEEDSERMNLPVYFRERHAKHSGGSSGTMLFGQPLLITVPRLNLTVDTLYERVLERI 641

  Fly   755 -------------------------------------HG-------------------------- 756
                                                 ||
Zfish   642 GRYVKRSQGTITESRASASATSSSSSQSPECLASVSSHGTGLSGCSSPVSDGASCSAGSNGSNHS 706

  Fly   757 ----------------------------------------------------------------- 756
                                                                             
Zfish   707 GTCNGPNGVCDGDEEAMDHQESPEPENSHSDTVDGEEDSEPENGPNSSGGKSFNSRPKLFSFSMV 771

  Fly   757 ----------------------------------------------------------------- 756
                                                                             
Zfish   772 NSYGTANISSLPFDGNLLKLTTHSTVAIDWDSDTKRLCYDDQEAEAYDKHESMLHAQKKKTTVAL 836

  Fly   757 ------------------WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM---- 799
                              |.||:||..:.|.||.|:..||.:||||||||        ||.
Zfish   837 RECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPRILVVHLKRF--------SYNRCWR 893

  Fly   800 -KKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKF 863
             |....:.||:.:|:|:.::...::   .|..|.|.|||||||.|.||||||:.|:...|||:.|
Zfish   894 DKLDTVVDFPIRDLNMSEFVCDPKA---DPYIYDLIAVSNHYGGMGGGHYTAYGKNKADGKWYYF 955

  Fly   864 DDQVVSALDSSNVVSSAAYILFY 886
            ||..|||.....:|:.|||:|||
Zfish   956 DDSSVSAATEDQIVTKAAYVLFY 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	14/73 (19%)
		Smc	<361..>511	CDD:440809	28/164 (17%)
		Peptidase_C19R	564..887	CDD:239139	149/672 (22%)
usp4	XP_002662556.2	UBP12	8..981	CDD:227847	212/1063 (20%)