DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and usp4

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:XP_002662556.2 Gene:usp4 / 449927 ZFINID:ZDB-GENE-041008-187 Length:1009 Species:Danio rerio


Alignment Length:1063 Identity:212/1063 - (19%)
Similarity:319/1063 - (30%) Gaps:511/1063 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   229 TKDAQPATNT---AISTLLDIL---------------KNWDPDVTYRAPIQIVEGGYEYFIM--- 272
            |:...|:|.:   :|.|||..|               |.|...|           |::.:.:   
Zfish    22 TQTPVPSTESQKQSIGTLLKTLLRKGDEWYLIDSRWFKQWKKYV-----------GFDSWDLYNV 75

  Fly   273 ----MYPTHCTNPSVQAPQQNNNDIE-TIDDIEYPSIHDITMKEDISAKDFRPRPDFNRA----- 327
                :||....|..:.:.:::.:..| .||:::|..:               |...:|:.     
Zfish    76 GEHNLYPGPIDNSGLFSDRKSQSLKEHLIDELDYVLV---------------PTEAWNKLVSWYG 125

  Fly   328 ----NKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGL 388
                .||...:|.|.|:                   |::..:.....||               |
Zfish   126 SLGNQKPIIRKVVEHGM-------------------FVKHCKVEVYLLE---------------L 156

  Fly   389 NATEDQELHFRILQLESKAQDYIVENNRLREELSRIQ-ELHNVTQQLSQKEVEATRNIESKIRER 452
            |..|:..:...:.:..|||           :.:..|: |:.::....|:||........|...|:
Zfish   157 NLCENDNMDKVVTRHFSKA-----------DTIDTIEKEMRSLFDIPSEKETRLWNKYMSNTYEQ 210

  Fly   453 -QRLDEQHELERQERERLLAIARETKK--------HYKSPTPSG-----PPSPGRNLEDVHVVSD 503
             .:||...:.....:.::|.|.::.:.        |.||.|.:.     .|.|..|       |.
Zfish   211 LNKLDSTVQDAGLFQGQVLVIEKKNEDGTWPRQSCHSKSSTSTSRNYTTSPKPSSN-------SS 268

  Fly   504 SLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGR------GL 562
            :..|.....||.:    .|...:           .|...:..|:..::........|      ||
Zfish   269 ATISSTITNGDSN----SNSGYM-----------LNNSTSGNRLGSYNSYSSSYSYRESAAQPGL 318

  Fly   563 TGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQ 625
            .||.||||||:|||.||||||||.||||.:.|:|:..|:|.|.  ..|::.|..|.|:|::|..:
Zfish   319 CGLSNLGNTCFMNSALQCLSNTPPLTEYFLEDRYEAEINRENPLGMRGEIAEAYADLVKQMWLSR 383

  Fly   626 YKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVP----------RQREMI 680
            ...||.|..:..||::...|.|..||||.|.|..|:|.||.||..:...          |..|::
Zfish   384 SSYVAPRTFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLALRDAEGRPDEIV 448

  Fly   681 SASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP------------ 733
              :::||.......:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||            
Zfish   449 --AKEAWANHRLRNDSIIVDIFHGLFKSTLVCPECSKVSVTFDPFCYLTLPLPMKKDRTMEVYLV 511

  Fly   734 ----------------------------------PNSNVC-----------------QLNQCMD- 746
                                              |:.|:.                 .|||.|: 
Zfish   512 RTDPQFRAMQFRVVVPKMGAVADLCSALAKLSGVPSENMVVADVYNHRFHKIYKRDDGLNQIMEK 576

  Fly   747 -------------------MYF-----------SG---------------------------ERI 754
                               :||           ||                           |||
Zfish   577 DDIFVYEVLEEDSERMNLPVYFRERHAKHSGGSSGTMLFGQPLLITVPRLNLTVDTLYERVLERI 641

  Fly   755 -------------------------------------HG-------------------------- 756
                                                 ||                          
Zfish   642 GRYVKRSQGTITESRASASATSSSSSQSPECLASVSSHGTGLSGCSSPVSDGASCSAGSNGSNHS 706

  Fly   757 ----------------------------------------------------------------- 756
                                                                             
Zfish   707 GTCNGPNGVCDGDEEAMDHQESPEPENSHSDTVDGEEDSEPENGPNSSGGKSFNSRPKLFSFSMV 771

  Fly   757 ----------------------------------------------------------------- 756
                                                                             
Zfish   772 NSYGTANISSLPFDGNLLKLTTHSTVAIDWDSDTKRLCYDDQEAEAYDKHESMLHAQKKKTTVAL 836

  Fly   757 ------------------WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM---- 799
                              |.||:||..:.|.||.|:..||.:||||||||        ||.    
Zfish   837 RECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPRILVVHLKRF--------SYNRCWR 893

  Fly   800 -KKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKF 863
             |....:.||:.:|:|:.::...::   .|..|.|.|||||||.|.||||||:.|:...|||:.|
Zfish   894 DKLDTVVDFPIRDLNMSEFVCDPKA---DPYIYDLIAVSNHYGGMGGGHYTAYGKNKADGKWYYF 955

  Fly   864 DDQVVSALDSSNVVSSAAYILFY 886
            ||..|||.....:|:.|||:|||
Zfish   956 DDSSVSAATEDQIVTKAAYVLFY 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087 14/73 (19%)
UCH 562..886 CDD:278850 148/672 (22%)
Peptidase_C19R 564..887 CDD:239139 149/672 (22%)
usp4XP_002662556.2 UBP12 8..981 CDD:227847 212/1063 (20%)
DUSP 44..141 CDD:197831 17/122 (14%)
Ubiquitin_3 155..242 CDD:291502 18/112 (16%)
Peptidase_C19 319..>507 CDD:271592 74/189 (39%)
USP7_C2 526..>606 CDD:291217 8/79 (10%)
Peptidase_C19R <834..979 CDD:239139 60/156 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 277 1.000 Domainoid score I1692
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1591
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.940

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