DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and USP27X

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001138545.1	Gene:	USP27X / 389856	HGNCID:	13486	Length:	438	Species:	Homo sapiens

Alignment Length:	405	Identity:	122/405 - (30%)
Similarity:	193/405 - (47%)	Gaps:	75/405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 EIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTE 589
            :.||:: ..||:...:....:|.|     |..:...||.||.||||||:||.|:|.|::||.|.:
Human    46 KFPTWE-TTKPELELLGHNPRRRR-----ITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRD 104

  Fly   590 YCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSH 654
            :.:||:::..:......   ::.|:::|.:||::|.........|.::|..:.:...|..|||:|
Human   105 FFLSDRHRCEMPSPELC---LVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAH 166

  Fly   655 EFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKES------MILHLFYGQMKSTVKCV 713
            |||...:|.||...:...|                 .||..:      :|..:|.|.::|.|.|.
Human   167 EFLIAALDVLHRHCKGDDV-----------------GKAANNPNHCNCIIDQIFTGGLQSDVTCQ 214

  Fly   714 ACHKESATYESFSNLSLELP-------PNS--------------NVCQLNQCMDMYFSGERIHG- 756
            |||..|.|.:...::||:||       |.|              .:..|..|:..:...|.:..
Human   215 ACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSS 279

  Fly   757 --WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKK-QNYLRFPLENLDMNPYI 818
              ..|.||::.:::.|:|.::|||.|...|.|||    .:|....:| ..|:.|||| |||.|::
Human   280 AKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF----EHSAKQRRKITTYISFPLE-LDMTPFM 339

  Fly   819 ARA-ESR-----------AVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSAL 871
            |.: |||           ......|.|:||.||.||:|.||||:|.:. :..:|||.||.|::..
Human   340 ASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRH-HKDQWFKCDDAVITKA 403

  Fly   872 DSSNVVSSAAYILFY 886
            ...:|:.|..|:|||
Human   404 SIKDVLDSEGYLLFY 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	112/366 (31%)
		Peptidase_C19R	564..887	CDD:239139	113/366 (31%)
USP27X	NP_001138545.1	Peptidase_C19D	78..419	CDD:239125	113/367 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940