DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and USP17L2

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_958804.2	Gene:	USP17L2 / 377630	HGNCID:	34434	Length:	530	Species:	Homo sapiens

Alignment Length:	439	Identity:	115/439 - (26%)
Similarity:	196/439 - (44%)	Gaps:	113/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 HYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFD------RAMKPQP 537
            |:...|.|.|              |:..:.:|.|..|:.:...::|.:...|      |.:.|:
Human    16 HFSKLTSSRP--------------DAAFAEIQRTSLPEKSPLSSEARVDLCDDLAPVARQLAPR- 65

  Fly   538 RNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKN---- 598
            :.:..:|:|    ...:|       .||:|:|||||.|:.||||:.||.|..|.:|.::..
Human    66 KKLPLSSRR----PAAVG-------AGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQR 119

  Fly   599 -----------YISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQD 652
                       :|:.:..:.|.||:...||......|:                        |:|
Human   120 PKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGK------------------------QED 160

  Fly   653 SHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTK-----AKESMILH-LFYGQMKSTVK 711
            :||||...:|                   |.:||.|...|     :|::.::| :|.|..:|.:|
Human   161 AHEFLMFTVD-------------------AMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIK 206

  Fly   712 CVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLD 773
            |:.||..|.|::.:.:::|::....:|   .|.::.....|.::|   ::|..|..:..|.|.|.
Human   207 CLHCHGISDTFDPYLDIALDIQAAQSV---KQALEQLVKPEELNGENAYHCGLCLQRAPASKTLT 268

  Fly   774 ISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSN 838
            :.....||::.||||   ...:|:.:.|.  :::| |.|||.||:::..:   .|..|.||||..
Human   269 LHTSAKVLILVLKRF---SDVTGNKLAKN--VQYP-ECLDMQPYMSQQNT---GPLVYVLYAVLV 324

  Fly   839 HYG-TMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |.| :...|||.::.| |..|:|:|.||..|:|...::|:|..||:|||
Human   325 HAGWSCHDGHYFSYVK-AQEGQWYKMDDAKVTACSITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	98/348 (28%)
		Peptidase_C19R	564..887	CDD:239139	100/348 (29%)
USP17L2	NP_958804.2	Peptidase_C19E	79..373	CDD:239126	101/357 (28%)
		UCH	80..372	CDD:278850	98/347 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..416
		Mediates interaction with SUDS3. /evidence=ECO:0000269\|PubMed:21239494	399..530
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920