Protein Alignment Usp8 and USP50

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_987090.2
• Gene: USP50 / 373509
• HGNCID: 20079
• Length: 334
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 103/302 - (34%)
• Similarity: 160/302 - (52%)
• Gaps: 18/302 - (5%)

  Fly   560 RGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNG 624
            :|:|||.||||||.:|:|.|||.:...|.||.::.|   ||:.......:|....|.|:.::|.|
Human    41 QGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGK---YITALQNDCSEVATAFAYLMTDMWLG 102

  Fly   625 QYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISAS-EKAWL 688
            ...||:.......:|.....|....|||:.|||..:::.||..|:..|..|:|.....| ::...
Human   103 DSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCCR 167

  Fly   689 EFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGER 753
            ::...:.|:|..||..|:..::.|:.|.|.:...|.|:..||.: |:...|.|..|:..:|..:.
Human   168 KWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLPI-PSKYECSLRDCLQCFFQQDA 231

  Fly   754 IHGWN----CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKK-QNYLRFPLENLD 813
            : .||    |..|:||::...:..|||.|.:::.|||||    ...|:..:| :..:.:||.|||
Human   232 L-TWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRF----DIQGTTKRKLRTDIHYPLTNLD 291

  Fly   814 MNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSA 855
            :.|||.....:  .|| |.|.||.||:|.::|||||||||::
Human   292 LTPYICSIFRK--YPK-YNLCAVVNHFGDLDGGHYTAFCKNS 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809
		Peptidase_C19R	564..887	CDD:239139	101/298 (34%)
USP50	NP_987090.2	UCH	44..329	CDD:425685	101/296 (34%)