DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and Usp3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001020595.2	Gene:	Usp3 / 363084	RGDID:	1308852	Length:	520	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	137/429 - (31%)
Similarity:	203/429 - (47%)	Gaps:	58/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 DVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRG 561
            |..||:|:...|:|...:....: .|.|.  |.||..|   |.:...|........|.|......
  Rat    99 DDFVVNDTKLGLVQKVREHLQNL-ENSAF--TADRHRK---RKLLENSSLNSKLLKVNGSTAAIC 157

  Fly   562 LTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDK--------------YKNYISRS-NKTNGQVI 611
            .|||:||||||:||:|||.|||   :.::|...|              .:.|.:|| ..:|..::
  Rat   158 ATGLRNLGNTCFMNAILQSLSN---IEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSLV 219

  Fly   612 EEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQ------- 669
            ||....:..||.|.....:...|.|||.:....|||..|||:|||:..|:|.||.:||
  Rat   220 EEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVS 284

  Fly   670 TLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP- 733
            ...:.::...:||:.|..:   ....:::..:|.|.:::.|.|:.|..||..::.|.:|||::|
  Rat   285 RSAILQENSTLSANNKCCI---NGASTVVTTIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPS 346

  Fly   734 ----------PNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHL 785
                      .|..||.|..|:..:...|.:..   :.|..||.|:.:.||..|.|||..|.:||
  Rat   347 QFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHL 411

  Fly   786 KRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEG-GH 847
            |||:..     :|:  |...|::|||..|||..|:...|:.......|.|.||..|:|:..| ||
  Rat   412 KRFHWT-----AYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVVVHHGSGVGSGH 471

  Fly   848 YTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |||:  :.:.|:||.|:|..|:..|...|..:.||||||
  Rat   472 YTAY--AVHEGRWFHFNDSTVTVTDEETVGKAKAYILFY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	119/362 (33%)
		Peptidase_C19R	564..887	CDD:239139	120/362 (33%)
Usp3	NP_001020595.2	zf-UBP	29..105	CDD:396634	3/5 (60%)
Usp3	NP_001020595.2	UCH	159..508	CDD:395355	119/361 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920