DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and Usp29

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001101935.1	Gene:	Usp29 / 361495	RGDID:	1306648	Length:	872	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	101/442 - (22%)
Similarity:	171/442 - (38%)	Gaps:	110/442 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 LESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELERQERE 467
            :|...:|.:.|||..:::.||..               .:||...|..:...|.||.:....:.|
  Rat   188 VEVTTKDILKENNPEQKKKSRRY---------------YSRNRGGKAEKAVALREQEKRNNWKLE 237

  Fly   468 RLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRA 532
            ...     :.|.|...|..|...|      :...||..:  |.:.|          .||.|.: .
  Rat   238 PAF-----SSKVYGKSTLDGTVLP------IATCSDDRD--LSIFG----------LEIITHN-G 278

  Fly   533 MKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYK 597
            ::|.|.|..:..:|                .|..|||||||||||||.:...|...:..:
  Rat   279 IQPPPDNYLKQLKR----------------EGFPNLGNTCYMNSILQSVFGIPTFAKDLL----- 322

  Fly   598 NYISRSNKTNGQVIEEVA-----------ALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQ 651
                    |.|...|:|:           .::|::.:.:.|......::..:......|.|.:|.
  Rat   323 --------TQGIPWEKVSYDDLIMPLSQLLVLKDIRDIEIKGELLTSVKKSISTVADTFSGNEQN 379

  Fly   652 DSHEFLTILMDWLHSDLQTLH----VPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKC 712
            |:||||::.:|.|..:::.::    ..|:.|...|..|.::....|.....||       |::.|
  Rat   380 DAHEFLSLCLDQLKLNMEKVNAMWDTERKNEPTCAGAKRFVCPVGANFEFELH-------SSIIC 437

  Fly   713 VACHKESATYESFSNLSLEL--PPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLDIS 775
            ..|.:.:...|..:.||::|  ...::...:.:..|::|:.|:|. .||..||.| :::.|..:.
  Rat   438 EGCGEATLKTEVSNYLSIDLHHGTKTHPLSIQKSFDLFFTPEKIE-HNCEKCKNK-NSVLKYTLR 500

  Fly   776 KLPPVLVVHLKRFYADPS----------------NSGSYMKKQNYLRFPLEN 811
            :||.||:|||||:.....                |..|:..:...|.|||.|
  Rat   501 RLPRVLIVHLKRYQVTTDLLPVKSEQPVEISQYLNISSHCHENRKLPFPLIN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	71/283 (25%)
		Peptidase_C19R	564..887	CDD:239139	71/281 (25%)
Usp29	NP_001101935.1	PH_USP37_like	4..109	CDD:270122
		UCH	294..560	CDD:395355	71/281 (25%)
		Peptidase_C19	<765..826	CDD:351799
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810