DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usp8 and Usp14

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001260321.1 Gene:Usp14 / 34387 FlyBaseID:FBgn0032216 Length:475 Species:Drosophila melanogaster


Alignment Length:541 Identity:110/541 - (20%)
Similarity:178/541 - (32%) Gaps:220/541 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   451 ERQRL--------DEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLES 507
            :||::        |:|..|:.::...:|.:..      |...|..|.:|.:.:||:         
  Fly    42 DRQKVMCKGGILKDDQWNLQIKDGAVVLLLGS------KESVPEVPATPVKFIEDM--------- 91

  Fly   508 LLQLTGDPDPTIAPNKAEIPTFDRAMK-PQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNT 571
                          |:||..|   ||: |                           .||.|||||
  Fly    92 --------------NEAEAAT---AMRLP---------------------------AGLTNLGNT 112

  Fly   572 CYMNSILQCLSNTPQL----------------TEYCISDKYKNYISRSNKTNGQVIEEVAALIKE 620
            ||||:.:|||:..|:|                |.:.||...|:..::..|  |..:..: .|::.
  Fly   113 CYMNATVQCLNAVPELRTALSTFSNDGTDTMSTAFSISSAMKSIFAQMEK--GTTVTPI-VLLQA 174

  Fly   621 LW-----------NGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVP 674
            |.           ||.|:                      |||::|....::..|...|:    |
  Fly   175 LHRASPQFAQTGENGTYR----------------------QQDANECWAEILKMLQQKLR----P 213

  Fly   675 RQREMISASEKAWLEFTKAKESMILHLFYG---QMKSTVKCVACHKESATYESFSNLSLELPPNS 736
            :.:|..:..:|        :.|..:..|:|   ::|.:.:.......:.|.|:|..||       
  Fly   214 KNQEPSNTVQK--------RHSSFIDQFFGGTFEVKMSSEEDPDEPSTVTSENFLQLS------- 263

  Fly   737 NVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLD-------------ISKLPPVLVVHLKRF 788
              |.::..:....||.:        .|.|...:||.:             :|:||..|.|...||
  Fly   264 --CFISMDVKYMQSGLK--------SKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTVQFVRF 318

  Fly   789 YADPSNSGSYMKKQNYLRFP--------------------------LENLDMNPYIARAESRAVT 827
            .. ....|...|....::||                          ||:..|...:.:.......
  Fly   319 QY-KGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRNEPNEE 382

  Fly   828 PKT-------------------YQLYAVSNHYG-TMEGGHYTAFCKSANYGKWFKFDDQVVSALD 872
            .|.                   |.|.||..|.| :...|||.|:.:|:. ..||||||..|||:.
  Fly   383 KKDVKYEQFWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSG-DVWFKFDDDEVSAVA 446

  Fly   873 SSNVVS-------SAAYILFY 886
            :..::.       ..||:|.|
  Fly   447 TDEILRLSGGGDWHCAYVLLY 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 90/419 (21%)
Peptidase_C19R 564..887 CDD:239139 91/419 (22%)
Usp14NP_001260321.1 UBQ 4..73 CDD:214563 6/30 (20%)
UBQ 5..73 CDD:294102 6/30 (20%)
UCH 103..467 CDD:278850 91/446 (20%)
Peptidase_C19A 105..467 CDD:239122 90/417 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45456851
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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