Protein Alignment Usp8 and Usp2

DIOPT Version :9

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 1046
• Identity: 246/1046 - (23%)
• Similarity: 389/1046 - (37%)
• Gaps: 324/1046 - (30%)

  Fly    66 MLTAIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLRHRYAQQHQAPEPIAPDLVSNGR 130
            |:..|.|...:  ||......|..|.....::.|          ..:.|::.|.|       .|.
  Fly     1 MMLDIKKTRGF--HKIPQASKLQSTTKTSSVVAT----------SASSQNEVPSP-------GGS 46

  Fly   131 AGVDSPITQPTQYA--RLGLITCQDLYRRMQEKSVLVMDCRPSADYEASHLTYYCAFNVPEELIT 193
            ||.....|.|.:.|  |..|::      ..::.:.|..:|    |...:|:|
  Fly    47 AGSKVGATNPVRAANQRFFLVS------SYKDPTFLKAEC----DLAHAHVT------------- 88

  Fly   194 PGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDA----------------QPAT------ 236
                    .:::.::.:....||:.:|| ...::||..|                ||.|
  Fly    89 --------TSKVKTTLQPHRRSRAGEDS-RNNNYNTSRAPTLINMRRPSLFNGNQQPTTTNSTTI 144

  Fly   237 ------NTAISTLLDILKNWDPDVTYRA------------PI---QIVEGGYEYFIMMYPTHCTN 280
                  ||..:|...:||......|..|            |:   |...|     :.|...|..|
  Fly   145 NNTTSRNTTSNTSNGVLKYSVRSTTATATSTSTRNYGKLKPLNNNQTTAG-----VAMMNGHTNN 204

  Fly   281 PSVQAPQQNNNDIETIDDIEYPSIHDITMK----EDISAKDFRPRPDFNRANKPAATRVNEQGIS 341
                    |||:.....:|.....:::..:    :|||         |..::.|.||...|.|||
  Fly   205 --------NNNNTRNSSNINNGGNNNMQRQQQQHDDIS---------FIDSDDPPATGGPEAGIS 252

  Fly   342 RPS------PPAKPIAEIMRDQAEFLQRAEQNDEQLEK-ASKMWKRQAAE--------------- 384
            ...      .|..|..::..:|.:..|:.||......| ||..:.|..:.
  Fly   253 TTKTSICYFKPITPPLQLRHEQNQVQQQEEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEK 317

  Fly   385 -GDGLNATEDQELHFRILQLESK----AQDYIVENNRLREELSRIQELHNVTQQLSQK------- 437
             ..||....:.|.:     :|||    |:.|.:::..::   :.|::.:|::.|..|.
  Fly   318 FSGGLYRQTNGETN-----IESKTSSNARRYGIDSLSIK---ASIEKFNNLSGQKRQNPGSGSGI 374

  Fly   438 ---------------EVEATRN-------IESKIRER--QRLDEQHELERQERERLLAIARETKK 478
                           .|.:..|       ..|.:::|  ..||..............|..|.|..
  Fly   375 GPGSATASGLGGGRLSVASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTAT 439

  Fly   479 HYKSPTP---------------------SGPPSPGRNLEDVH-----VVSDSL----ESLLQLTG 513
            .....||                     .|.|:....:...|     :..||:    ::....|.
  Fly   440 MNSVSTPVAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATT 504

  Fly   514 DPDPTI----------------------APNKAEIPTFDRAMKPQP------RNVERTSQRVRDF 550
            ...||:                      |||.|. .:..|::...|      |:...:|...|..
  Fly   505 AATPTVATATATHTPATSSVSTVTVTAAAPNSAS-DSVSRSLARSPISSTLARSGTGSSSTARSV 568

  Fly   551 SPVIGQNVGR--------------------------------------------GLTGLKNLGNT 571
            .|.:.....|                                            ||.||:|:|||
  Fly   569 LPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNT 633

  Fly   572 CYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKT-NGQVIEEVAALIKELWNGQYKCVASRDLR 635
            |:|||::||||:|.:||.:..|    ::.|||..| :.|::.|.|.||:|:|......|...:|:
  Fly   634 CFMNSVIQCLSHTQELTRFLRS----HHGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELK 694

  Fly   636 YVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDL------QTLHVPRQREMISASEKA---WLEFT 691
            .......:::...:|||:.|||...:|.|||.|      :||::.   :.:|.::||   |..:|
  Fly   695 RAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVKGETLNID---DNLSDNKKADLTWEWYT 756

  Fly   692 KAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHG 756
            :.:.|::..||.||:|||:||..|...|.|::.|.:||:.||.:|. |:|..|:|::...|.:.|
  Fly   757 RHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSR-CKLEACLDLFIREEVLDG 820

  Fly   757 ---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLEN--LDMNP 816
               ..|..|||:|...|...|.:.|..||:|||||     :...:.|..|.:.||..:  |:|..
  Fly   821 DEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRF-----SETRWSKLSNIVEFPTSDSELNMGS 880

  Fly   817 YIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVS-ALDSSNVVSSA 880
            |.|.:.|..    .|.|||:|||.|:..||||.|.||.....||.:|:|.:|| ||..:::|||:
  Fly   881 YGANSNSNV----HYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSS 941

  Fly   881 AYILFY 886
            ||||||
  Fly   942 AYILFY 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108	8/46 (17%)
		RHOD	148..278	CDD:294087	27/172 (16%)
		UCH	562..886	CDD:278850	129/339 (38%)
		Peptidase_C19R	564..887	CDD:239139	130/339 (38%)
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	129/339 (38%)
		Peptidase_C19R	626..948	CDD:239139	130/339 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456849
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14509at33392
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	1	1.000	-	-		otm14283
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	1	1.100	-	-	P	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.780