DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and Usp37

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_795946.2 Gene:Usp37 / 319651 MGIID:2442483 Length:979 Species:Mus musculus


Alignment Length:537 Identity:127/537 - (23%)
Similarity:220/537 - (40%) Gaps:88/537 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   295 TIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAE 359
            |:.|..:.||..:..|:   |::.|...|....|:..|.....||    |.....|......|.|
Mouse    75 TLQDNSFLSIDKVPSKD---AEEMRLFLDAVHQNRLHAAMKASQG----SGSFGTILGSRTSQKE 132

  Fly   360 FLQRAEQNDEQ-------LEKASKMWKR-----------QAAEGDGLNATE--------DQELHF 398
            ..::...:|.|       ||...::..|           :...|.|:..|.        ...|..
Mouse   133 TNRQLSYSDNQASSKRGSLETKDEIPFRKVLGSPGRGPIKTVTGGGMAVTRTIPSLTLTSTPLRS 197

  Fly   399 RILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELER 463
            .:|:..::.:..::..:.|.|:..:    .|.:...::...:.:|...:..||:|.     .|::
Mouse   198 GLLENRTEKRKRMLSGSELTEDYPK----ENDSSSNNKAMTDPSRKYLTSCREKQL-----SLKQ 253

  Fly   464 QERER---LLAIARETKKHYKSPTPSGPPSPG-RNLEDVHVVSDSLESLLQLTGDPDPTIAPNKA 524
            .|..|   ||.:  ::...|.|...|...|.| .||:..:|.|.:..:...|...|.||....|.
Mouse   254 AEENRTSGLLPL--QSSSFYGSRAGSKDYSSGVTNLDRCNVSSQTPSAKRSLGFLPQPTPLSVKK 316

  Fly   525 EIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTE 589
            .....|.|...:|| |..:|.:             :.|.|..|||||||||:|||.|.:..... 
Mouse   317 LRCNQDYAGWNRPR-VPLSSHQ-------------QQLQGFSNLGNTCYMNAILQSLFSLQSFA- 366

  Fly   590 YCISDKYKNYISRSNKTNGQVIEEVAALI--KELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQD 652
               :|..|..|.........:|...|.|:  |::.|.:.|....:.::..:....:.|.|..|.|
Mouse   367 ---NDLLKQSIPWKKIPFNALIRRFANLLIKKDICNSETKKELLKKVKNAISATAERFSGYVQND 428

  Fly   653 SHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKE----SMILHLFYGQMKSTVKCV 713
            :||||:..:|.|..|::.|:...:.|.:...|.  |..|.|.:    .:|.:|.: :::.::.|.
Mouse   429 AHEFLSQCLDQLKEDMEKLNKTWKTEPVLGEEN--LPDTSATKVFTCPVITNLEF-EVQHSIICK 490

  Fly   714 ACHKESATYESFSNLSLE-------LPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKK 771
            ||.:.....|.|::||::       |||.|    :...:|::|..|.:. ::|..|..| .|:.:
Mouse   491 ACGETIPKREQFNDLSIDLPRRKKPLPPRS----IQDSLDLFFRAEELE-YSCEKCGGK-CALVR 549

  Fly   772 LDISKLPPVLVVHLKRF 788
            ...::||.||::||||:
Mouse   550 HKFNRLPRVLILHLKRY 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 69/240 (29%)
Peptidase_C19R 564..887 CDD:239139 68/238 (29%)
Usp37NP_795946.2 UCH_N 3..105 CDD:406959 8/32 (25%)
KEN box 1. /evidence=ECO:0000250 32..34
D-box 1. /evidence=ECO:0000250 71..79 1/3 (33%)
D-box 2. /evidence=ECO:0000250 96..105 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..178 11/65 (17%)
D-box 3. /evidence=ECO:0000250 160..168 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..240 6/51 (12%)
KEN box 2. /evidence=ECO:0000250 222..224 0/5 (0%)
UCH 342..>601 CDD:395355 68/238 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..795
KEN box 3. /evidence=ECO:0000250 782..784
Peptidase_C19 <886..949 CDD:239072
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1868
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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