DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and Usp18

DIOPT Version :10

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001014080.1 Gene:Usp18 / 312688 RGDID:1359153 Length:362 Species:Rattus norvegicus


Alignment Length:380 Identity:87/380 - (22%)
Similarity:155/380 - (40%) Gaps:69/380 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   535 PQPRNV---ERTSQRVRDFSPVIGQNVGR--GLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISD 594
            ||..:.   |:..:|.|..|..:.....|  |..||.|:|.||.:||::|.         :.::.
  Rat    19 PQQHSALEEEKNMKRKRVLSRELCSAWDRPHGFVGLHNIGQTCCLNSLIQV---------FMMNV 74

  Fly   595 KYKNYISRSNKTNG------QVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQ-KIFRGVDQQD 652
            .::..:.|.....|      .|..::..|::::.:.:.|.|...:|...:.:|. .:|  |....
  Rat    75 DFRMVLKRITVPRGAEEQKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVPLF--VQHDA 137

  Fly   653 SHEFLTILMDW-LHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACH 716
            :|.||||   | |..|        |...|..:|:            :..||....:.::.||.|.
  Rat   138 AHLFLTI---WNLTKD--------QITDIDLAER------------LQDLFTIWTEESLMCVGCG 179

  Fly   717 KESATYESFSNLSLEL--PPNSNVCQLNQCMDMYFSGERIHGWN---CPSCKTKRDAIKKLDISK 776
            .||:.......|||.|  ..:..:..|...:..:|..:.:...:   |.:|..|....:...::.
  Rat   180 AESSRRGKLLTLSLPLFDMDSKPLKTLEDALRCFFQPKELASSDKCFCETCGKKTPCKQAQKLTG 244

  Fly   777 LPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYG 841
            .|..|.:||.||....|.:   :|..:.:.|| ::||.:..:...:...:   .|:|:||..|.|
  Rat   245 FPQTLTIHLMRFSVRNSQT---VKICHSVYFP-QSLDFSQILPTTDQSEI---HYELFAVIAHVG 302

  Fly   842 TMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSS----------AAYILFY 886
            ..:.|||.|:.::...|:||.|:|..|..:...:|..:          .||:|.|
  Rat   303 MADFGHYCAYIRNPVDGEWFCFNDSHVCWVTWKDVQCTYGDHIYRWRETAYLLVY 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..114 CDD:462647
RHOD 148..278 CDD:444705
Smc <361..>511 CDD:440809
Peptidase_C19R 564..887 CDD:239139 79/346 (23%)
Usp18NP_001014080.1 UCH 52..357 CDD:425685 78/345 (23%)
Blue background indicates that the domain is not in the aligned region.

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