DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and Usp32

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_038941969.1	Gene:	Usp32 / 303394	RGDID:	1306657	Length:	1683	Species:	Rattus norvegicus

Alignment Length:	1461	Identity:	230/1461 - (15%)
Similarity:	387/1461 - (26%)	Gaps:	756/1461 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKKLHMSSNLDDLEKMSIIPDLRSKGMKILLN---TARKLYMTAEEYRLDGDEELAYITYMKYFN 65
            |.::...:..||:.::.:  || |..::.:||   |.:..::|.|:|::   ..:..:...::.|
  Rat   361 LLEVWKDNRTDDIPELHM--DL-SDIVERILNAHDTTKMGHLTLEDYQI---WSVKNVLANEFLN 419

  Fly    66 ML-----TAIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLR-----HRYAQQHQAPEP 120
            :|     ..:..:...|..:..:.:...:.||...:.......|.|::     ..|.:....|..
  Rat   420 LLFQVCHIVLGLRPATPEEEGQIIRGWLERESRYGLQPGHNWFIISMQWWQQWKEYVKYDANPVV 484

  Fly   121 IAPDLVSNGRAGVDSPITQPTQYARLGLITCQDLYRRMQEKSVLVMDCRPSADYEASHLTYYCAF 185
            |.|..|.||..........|.::..                           |..:::|:|   .
  Rat   485 IEPSSVLNGGKFSFGTTAHPIEHGE---------------------------DRISNNLSY---M 519

  Fly   186 NVPEELITPGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAISTLLDILKNW 250
            |..||..:..:|:.. :|..|:.:...:::....|.......||.|..  ....:....:||.:.
  Rat   520 NTTEEKYSDNISSAS-EASESTGSGFLYSATPGADMCFARQHNTSDNN--NQCLLGANGNILLHL 581

  Fly   251 DPD---------VTYRAPIQ----IVEGG-------------YE-----YFIMMYPTHCTNPSVQ 284
            :|.         :..:.|::    .:|||             ||     .:..:|..:.:|.::.
  Rat   582 NPQKPGAIDNQPLVTQEPVKATSLTLEGGRLKRTPQLIHGRDYEMVPEPVWRALYHWYGSNLALP 646

  Fly   285 APQQNNNDIETIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGI--------- 340
            .|...|:                  |.||...:..||.......:| |||..:..|
  Rat   647 RPVIKNS------------------KTDIPELELFPRYLLFLRQQP-ATRTQQSNIWVNMGMMSL 692

  Fly   341 ----------SRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGLNATEDQE 395
                      :.|||.| |:..::.....|              |:|             ...:|
  Rat   693 RMFPQHLPRGNVPSPNA-PLKRVLAYTGCF--------------SRM-------------QTIKE 729

  Fly   396 LHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHE 460
            :|           :|:.:..|::||..|:. |:|....|:..:                 ||.|.
  Rat   730 IH-----------EYLSQRLRIKEEDMRLW-LYNSENYLTLLD-----------------DEDHR 765

  Fly   461 LER---QERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPN 522
            ||.   |:.:.|:...|  .|....|            |::..:::|.:.              :
  Rat   766 LEYLKIQDEQHLVIEVR--NKDMSWP------------EEMSFIANSSKI--------------D 802

  Fly   523 KAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQL 587
            :.::||                              .:|.|||.||||||:|||.:||:|||..|
  Rat   803 RHKVPT------------------------------EKGATGLSNLGNTCFMNSSIQCVSNTQPL 837

  Fly   588 TEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQ 650
            |:|.||.::...::|:|.  ..|.:.:....|::|||:|..|.||...||:.:.:|...|.|..|
  Rat   838 TQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQ 902

  Fly   651 QDSHEFLTILMDWLHSDLQTLHVPRQREMISA--------SEKAWLEFTKAKESMILHLFYGQMK 707
            |||.|.|..|:|.||.||..:|.....|:..:        :.:||....:...|:::.||:||::
  Rat   903 QDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLR 967

  Fly   708 STVKCVACHKESATYESFSNLSLELP--------------------------------------- 733
            |.|||..|...|..::.|:.|||.||
  Rat   968 SQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPIRYGLRLNMDEKYTGLKKQL 1032

  Fly   734 ----------------------------------------------------------------- 733

  Rat  1033 SDLCGLKSEQILFAEVHSSNIKNFPQDNQKVRLSVSGFLCAFEIPIPASPVSACSPIQTDCSSSP 1097

  Fly   734 ------------------------PNS-------------------------------------- 736
                                    ||:
  Rat  1098 STNGLFTVTTNGDLPRPIFIPNGMPNTVVPCGTEKNATNGIVNGHMPPLPDDPFTGYIIAVHRKM 1162

  Fly   737 ----------------------------------------------------------------- 736

  Rat  1163 MRTELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCDDS 1227

  Fly   737 -------------------------------------------NVC------------------- 739
                                                       |.|
  Rat  1228 MGYQYPFTLRVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNACIAVDWDPTALHLRYQTSQE 1292

  Fly   740 --------------------QLNQCMDMYFSGERIHGWN----CPSCKTKRDAIKKLDISKLPPV 780
                                .|:.|:..:.|.|.: |.|    |..|||...|.||||:.:|||:
  Rat  1293 RVVEEHESVEQSRRAQAEPINLDSCLRAFTSEEEL-GENEMYYCSKCKTHCLATKKLDLWRLPPI 1356

  Fly   781 LVVHLKRFYADPSNSGSYMKKQNYLRFPLENLD-------------------------------- 813
            |::|||||   ...:|.::|.|..::||.|:.|
  Rat  1357 LIIHLKRF---QFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPTLCQHKPLTPQGDDVSELPIPA 1418

  Fly   814 --------MNP------------------------------------------------------ 816
                    .||
  Rat  1419 GDVKKVDVQNPAGEEDVLLSKSPSSLSANITSSPKGSPSSSRKSGASCPSSKNSSPNSSPRTLGR 1483

  Fly   817 ---------------------------------------------YIARAESRAVTP-------- 828
                                                         .:..::...|||
  Rat  1484 NKGRLRLPQIGSKNKLSSSKENLDASRENGAGQICELADTLNRGHVLGGSQPELVTPLDHEITLA 1548

  Fly   829 --------------------------------------KTYQLYAVSNHYGTMEGGHYTAFCKSA 855
                                                  ..|.|||:|.|.|.:.||||..:.|:.
  Rat  1549 NGFLYEHETCGNGYSNGQLGNHSEEDSTDDQREDTHSKPIYNLYAISCHSGILGGGHYVTYAKNP 1613

  Fly   856 NYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |. ||:.::|.....|....:.:.:||||||
  Rat  1614 NC-KWYCYNDSSCKELHPDEIDTDSAYILFY 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108	20/121 (17%)
		RHOD	148..278	CDD:294087	23/160 (14%)
		UCH	562..886	CDD:278850	132/835 (16%)
		Peptidase_C19R	564..887	CDD:239139	133/835 (16%)
Usp32	XP_038941969.1	FRQ1	254..404	CDD:227455	11/45 (24%)
		UBP12	583..1395	CDD:227847	160/949 (17%)
		UCH	<1314..1643	CDD:395355	57/333 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000