DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and ubp8

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_592992.1	Gene:	ubp8 / 2542135	PomBaseID:	SPAC13A11.04c	Length:	449	Species:	Schizosaccharomyces pombe

Alignment Length:	387	Identity:	100/387 - (25%)
Similarity:	162/387 - (41%)	Gaps:	99/387 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 DRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEY---- 590
            |....|:..|.....:..|.:.||...   .||.|::|||.||:|:.|||.:.:.|.:...
pombe   115 DHKRLPEKYNQMVCLEAYRKYPPVCAT---AGLRGIQNLGATCFMSVILQSILHNPLVRNLFFSG 176

  Fly   591 ---------------CISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQ 640
                           .|.|.:.:..:..||:   ......|::..:|                 :
pombe   177 FHTSTDCKRPTCMTCAIDDMFSSIYNSKNKS---TFYGPTAVLNLMW-----------------K 221

  Fly   641 YQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESM-----ILH 700
            ..|...|..|||.|||...|:|.:|::                       :....||     |..
pombe   222 LSKSLCGYSQQDGHEFFVYLLDQMHTE-----------------------SGGGTSMPCTCPIHR 263

  Fly   701 LFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTK 765
            :|.|.:|:.|.|:.|.||....:...::||::    |...|..|::.:.|.|::. ::|.||.:|
pombe   264 IFSGSLKNVVTCLDCKKERVAVDPLMDISLDI----NEPTLQGCLERFVSKEKVQ-YSCHSCGSK 323

  Fly   766 RDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQ-NY-----LRFPLENLDMNPYIARAESR 824
             :|||:|...||||.:.:.||||..:.....:.:.|| :|     :|:.....|::
pombe   324 -NAIKQLVFDKLPPTICMQLKRFEQNNFAMSTKIDKQVSYPAFLRMRYNFNQDDVD--------- 378

  Fly   825 AVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
                  ||||:|..|.||::.|||.|:....|  :||..||..:..:..|.|::|.||:|||
pombe   379 ------YQLYSVVCHKGTLDTGHYIAYTYYQN--QWFLLDDTTIVEVKESEVLNSQAYLLFY 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	91/353 (26%)
		Peptidase_C19R	564..887	CDD:239139	92/353 (26%)
ubp8	NP_592992.1	ZnF_UBP	37..85	CDD:197632
		UCH	144..432	CDD:278850	91/353 (26%)
		Peptidase_C19D	145..433	CDD:239125	92/354 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940