DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usp8 and Usp11

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_663603.3 Gene:Usp11 / 236733 MGIID:2384312 Length:921 Species:Mus musculus


Alignment Length:928 Identity:186/928 - (20%)
Similarity:289/928 - (31%) Gaps:414/928 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 ANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKAS-----------KMWKR 380
            |..|||..|......|.:.|     |.|.|..|..::.....|:..:|.           |.|:.
Mouse     5 AADPAAAAVPASAEDRDTQP-----EAMPDLDEQWRQIGNGRERPLRAGESWFLVEKHWYKQWEV 64

  Fly   381 QAAEGDGLNAT-----------EDQ---ELHFRILQ------LESKAQDYIVENNRLRE------ 419
            ....||...:|           |||   .|..|:|:      |.:.|.:|:|....|.:      
Mouse    65 YVKGGDQDASTFPGCINNAGLFEDQISWHLRERLLEGDDYVLLPAPAWNYMVSWYGLMDGQPPIE 129

  Fly   420 ----ELSRIQELHNVTQQL---SQKEVEATRNIESKIRER-----QRLDEQHELERQERERLLAI 472
                ||..|:::.....:|   ...::|....|:....:.     |...||..:|.||..||.  
Mouse   130 RKVIELPGIRKVEVYPLELLLVQHSDMETALTIQFSYTDSVELVLQTAREQFLVEPQEDTRLW-- 192

  Fly   473 ARETKKHYKSPTPSGPPSPGR--NLEDVHVVSDSLES---LLQLTGDPDPTIAPNKA----EIPT 528
                       |.:...|..|  |.: :.::...||:   ::..|.:.|.|....:.    .||.
Mouse   193 -----------TKNSEGSLDRLCNTQ-ITLLDACLETGQLVIMETRNKDGTWPSAQLCGMNNIPD 245

  Fly   529 FDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCIS 593
            .|...:.||                       |:.||.||||||:|||.||||||.||||||.::
Mouse   246 EDEDFQGQP-----------------------GICGLTNLGNTCFMNSALQCLSNVPQLTEYFLN 287

  Fly   594 DKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEF 656
            ::|...::..|.  ..|::.|..|.|:|:.|:|.::.:.....:..||.:...|.|..|.||.|.
Mouse   288 NRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKVGHFASQFLGYQQHDSQEL 352

  Fly   657 LTILMDWLHSDLQTLHVPRQREM--------ISASEKAWLEFTKAKESMILHLFYGQMKSTVKCV 713
            |:.|:|.||.||..:......|:        :..:::||....:..:|:|:..|:|..|||:.|.
Mouse   353 LSFLLDGLHEDLNRVKKKEYVELCNGAGRPDLEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCP 417

  Fly   714 ACHKESATYESFSNLSLELP---------------------------PN----SNVC-------- 739
            .|...|.|::.|..||:.||                           |.    |::|        
Mouse   418 DCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVPMDPRRKPEQHRVVVPKKGNISDLCVALSTHTS 482

  Fly   740 ----------------------------------------------------------------- 739
                                                                             
Mouse   483 VAPDKMIVADVFSHRFYKLYQLEDPLSGILDRDDIFVYEVTGRIEPVEGSRDDIVVPVYLRERTP 547

  Fly   740 ----------------------------------------------------------------- 739
                                                                             
Mouse   548 SRDYNNSYYGLILFGHPLLVSVPRDRFSWEGLYNILMYRLSRYVTKPTSDEDDGDEKVDEDEDED 612

  Fly   740 ----------------------------------------------------------------- 739
                                                                             
Mouse   613 VEDDSSSEEEKEEMSAPTVNDGTREAEQEQAGTSSGVTERCPSLLDNSLRASQWPPRRRRKQLFT 677

  Fly   740 -------------------------------------------------------------QLNQ 743
                                                                         ||.:
Mouse   678 LQTVNSNGTSDRTTSPEEMQTQPYIAMDWEPDMKRRYYDEVEAEGYVKHDCVGYMLKKSPVQLKE 742

  Fly   744 CMDMYFSGERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYL 805
            |:.::.:.|.:   :.|.|.|||..:.|.||||:..||.||::|||||   ..:..|..|....:
Mouse   743 CIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRF---SFSKISREKLDTLV 804

  Fly   806 RFPLENLDMNPYIARAESRAVTPKTYQ--LYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVV 868
            :||:.:||.:.::.:.::.: :|..|:  |.|||||||.|..||||.|..:.:.|:|..|||..|
Mouse   805 QFPIRDLDFSEFVIKPKNES-SPDLYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSV 868

  Fly   869 SALDSSNVVSSAAYILFY 886
            |.::.:.:.|.|||:|||
Mouse   869 SPVNENQIESKAAYVLFY 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 126/633 (20%)
Peptidase_C19R 564..887 CDD:239139 128/633 (20%)
Usp11NP_663603.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 9/28 (32%)
UBP12 23..888 CDD:227847 180/910 (20%)
DUSP 44..136 CDD:197831 18/91 (20%)
Ubiquitin_3 154..233 CDD:291502 19/92 (21%)
Peptidase_C19 <254..>370 CDD:271592 49/138 (36%)
Peptidase_C19 258..>437 CDD:271592 64/178 (36%)
USP7_C2 428..>541 CDD:291217 8/112 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..668 0/74 (0%)
Peptidase_C19R <737..887 CDD:239139 59/154 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 893..921
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1591
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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