DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and Usp3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_006511173.1	Gene:	Usp3 / 235441	MGIID:	2152450	Length:	606	Species:	Mus musculus

Alignment Length:	429	Identity:	138/429 - (32%)
Similarity:	203/429 - (47%)	Gaps:	58/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 DVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRG 561
            |..||:|:...|:|...:....: .|.|.  |.||..|   |.:...|........|.|......
Mouse   185 DDFVVNDTKLGLVQKVREHLQNL-ENSAF--TADRHRK---RKLLENSSLNSKLLKVNGSTTAIC 243

  Fly   562 LTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDK--------------YKNYISRS-NKTNGQVI 611
            .|||:||||||:||:|||.|||   :.::|...|              .:.|.:|| ..:|..::
Mouse   244 ATGLRNLGNTCFMNAILQSLSN---IEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSLV 305

  Fly   612 EEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQ------- 669
            ||....:..||.|.....:...|.|||.:....|||..|||:|||:..|:|.||.:||
Mouse   306 EEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVS 370

  Fly   670 TLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP- 733
            ...:.::...:|||.|..:   ....:::..:|.|.:::.|.|:.|..||..::.|.:|||::|
Mouse   371 RSAILQENSTLSASNKCCI---NGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPS 432

  Fly   734 ----------PNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHL 785
                      .|..||.|..|:..:...|.:..   :.|..||.|:.:.||..|.|||..|.:||
Mouse   433 QFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHL 497

  Fly   786 KRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEG-GH 847
            |||:..     :|:  |...|::|||..|||..|:...|:.......|.|.||..|:|:..| ||
Mouse   498 KRFHWT-----AYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVVVHHGSGVGSGH 557

  Fly   848 YTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            |||:  :.:.|:||.|:|..|:..|...|..:.||||||
Mouse   558 YTAY--AVHEGRWFHFNDSTVTVTDEETVGKAKAYILFY 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	120/362 (33%)
		Peptidase_C19R	564..887	CDD:239139	121/362 (33%)
Usp3	XP_006511173.1	zf-UBP	117..191	CDD:366940	3/5 (60%)
Usp3	XP_006511173.1	UCH	245..594	CDD:366104	120/361 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950