DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and USP22

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_056091.1	Gene:	USP22 / 23326	HGNCID:	12621	Length:	525	Species:	Homo sapiens

Alignment Length:	416	Identity:	125/416 - (30%)
Similarity:	195/416 - (46%)	Gaps:	74/416 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 LQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNTCY 573
            :|..|:...|..|.|.|:    ..:|..|:..:.||            |...||.||.||||||:
Human   138 MQGVGEKFSTWEPTKREL----ELLKHNPKRRKITS------------NCTIGLRGLINLGNTCF 186

  Fly   574 MNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLRYVV 638
            ||.|:|.|::||.|.::.:||:::   ......:..::.|:::|.:|.::|.........|.::|
Human   187 MNCIVQALTHTPLLRDFFLSDRHR---CEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLV 248

  Fly   639 GQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFY 703
            ..:.:...|.:|||:||||...:|.||         |..:.....:||  ........:|..:|.
Human   249 WTHARHLAGYEQQDAHEFLIAALDVLH---------RHCKGDDNGKKA--NNPNHCNCIIDQIFT 302

  Fly   704 GQMKSTVKCVACHKESATYESFSNLSLELPPNS------------NVCQ----------LNQCMD 746
            |.::|.|.|..||..|.|.:.|.::||:||.:|            ||..          |..|:.
Human   303 GGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLR 367

  Fly   747 MYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKK-QNYLRF 807
            .:...|.:..   ..|..|.:.:::.|:|.:.|||.|...|||||    .:|....:| ..|:.|
Human   368 RFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF----EHSAKLRRKITTYVSF 428

  Fly   808 PLENLDMNPYIARA-ESR-----------AVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKW 860
            ||| |||.|::|.: |||           ......|.|:||.||.||:|.||||:|.:. :..:|
Human   429 PLE-LDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQ-HKDQW 491

  Fly   861 FKFDDQVVSALDSSNVVSSAAYILFY 886
            ||.||.:::.....:|:.|..|:|||
Human   492 FKCDDAIITKASIKDVLDSEGYLLFY 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	111/361 (31%)
		Peptidase_C19R	564..887	CDD:239139	112/361 (31%)
USP22	NP_056091.1	zf-UBP	63..123	CDD:396634
USP22	NP_056091.1	Peptidase_C19D	176..518	CDD:239125	112/362 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940