Protein Alignment Usp8 and Usp43

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_776115.2
• Gene: Usp43 / 216835
• MGIID: 2444541
• Length: 1132
• Species: Mus musculus
• Alignment Length: 747
• Identity: 154/747 - (20%)
• Similarity: 226/747 - (30%)
• Gaps: 353/747 - (47%)

  Fly   450 RERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGD 514
            |.|:|    ..|.|.....|||:...::.....|.|...|||                   ..||
Mouse    17 RPRRR----RSLRRLLNRFLLALGSRSRSGDSPPRPPAQPSP-------------------YDGD 58

  Fly   515 PD------PTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGR---GLTGLKNLGN 570
            .:      |..||..|..|..||....||:               |....|.   |..||||.||
Mouse    59 GEGGFACAPGPAPASAGSPGPDRPPGSQPQ---------------ISSGDGARPPGAQGLKNHGN 108

  Fly   571 TCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVASRDLR 635
            ||:||:::||||||..|.|:....:|     |:.....:|.|::|||::.||..:|....|.:.:
Mouse   109 TCFMNAVVQCLSNTDLLAEFLALGRY-----RAAPGRAEVTEQLAALVRALWTREYTPQLSAEFK 168

  Fly   636 YVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQ-TLH------VPRQREMISASEKAWLEFTKA 693
            ..|.:|...|:|..|.|:.|||..|:|.:|.||: :.|      :|.:...||...:.....|..
Mouse   169 NAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSAHGLVSEQLPPEVSKISEDLRPSAAPTSL 233

  Fly   694 KESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP------------------------- 733
            ..|.:...|..|.:|::.|..|.|:|.|::.|..:||.:|
Mouse   234 GPSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGL 298

  Fly   734 --------------------------------PN------------------SNV---------- 738
                                            ||                  .||
Mouse   299 AVPILSTVAALRKMVAEEGGVPAEEVILVELYPNGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPG 363

  Fly   739 ----------------------------------------------------------------- 738
                                                                             
Mouse   364 LGTLSAHPSGLSVSPRLPVRDSQRFSGPLHSENRVVFLFCNLVGSGQQASRFGPPFLIREDRTIS 428

  Fly   739 ----------------------------------------------------------------- 738
                                                                             
Mouse   429 WAQLQQCILSKVRCLMRSEVSAQDLGTLFSIRVVGLSLACSYLSPKDNRPLCHWAVDRALHLRRP 493

  Fly   739 ----------------------------------------------CQLNQCMDMYFSGERI--- 754
                                                          |.|::|...|...|::
Mouse   494 GGPPHVKLAVEWDSSVTERLFGSLQEERVQDADSVWRQQQAHQQPSCTLDECFQSYTKEEQLAQD 558

  Fly   755 HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRF--YADPSNSGSYMKKQNYLRFPLENLDMNPY 817
            ..|.||.|:..:..:.||.:..||.:|::|||||  ..:..|     |....::|||..|:|.|:
Mouse   559 DAWKCPHCQVLQQGVVKLSLWTLPDILIIHLKRFCQVGERRN-----KLSTLVKFPLSGLNMAPH 618

  Fly   818 IARAESRA--------------VTPKT------YQLYAVSNHYGTMEGGHYTAFCKSANYGKWFK 862
            :||..:.:              ..|.|      |.||||.||:|:::||||||:|:::..|:|:.
Mouse   619 VARRSTNSKAGPGPWSSWKQPICLPTTYPLDFLYDLYAVCNHHGSLQGGHYTAYCRNSLDGQWYS 683

  Fly   863 FDDQVVSALDSSNVVSSAAYILFY---TWLPP 891
            :||..|.||....|.:..||||||   ..:||
Mouse   684 YDDSTVEALREDEVNTRGAYILFYQKRNSIPP 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809	13/60 (22%)
		Peptidase_C19R	564..887	CDD:239139	125/618 (20%)
Usp43	NP_776115.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		27/123 (22%)
		UBP12	<96..711	CDD:227847	126/624 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	839..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	935..1008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1024..1044
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1057..1106