DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp8 and usp-3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_493434.3	Gene:	usp-3 / 190579	WormBaseID:	WBGene00013506	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	109/359 - (30%)
Similarity:	167/359 - (46%)	Gaps:	80/359 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 GLKNLGNTCYMNSILQCLSNTPQLTEYCIS-DKYKNYISRSNKTNGQVIEEVAALIKELWNGQYK 627
            |::|:||||:||::||.|::..:..||.:| ...::||...               ||..||...
Worm   230 GMRNVGNTCFMNAVLQALASISEFREYIMSLSSLEDYIHDE---------------KEPKNGGNY 279

  Fly   628 CVASRDLRYVVGQYQKI----------------------------FRGVDQQDSHEFLTILMDWL 664
            |       |:..:|:|:                            |||..|.|||||:...||.|
Worm   280 C-------YLTDEYRKLLISQSARSFREPTAPNEFREAFISVCPRFRGFRQHDSHEFMRYFMDSL 337

  Fly   665 HSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLS 729
            |::::     :.|::....:.        |.:.|...|.|.::|:|.|..|...|...:.|.:||
Worm   338 HTEMR-----KCRKLPGMPDD--------KHTPISKYFEGTLQSSVICQTCRNCSNKIDEFMDLS 389

  Fly   730 LELPP--NSNVCQLNQCMDMYFSGERIHGW---NCPSCKTKRDAIKKLDISKLPPVLVVHLKRFY 789
            |::|.  |::..:|:.|:..:|..|.:...   .|..||||:...|::.|.|||.||.:|:|||
Worm   390 LDIPAQRNASKVRLSDCLSTFFKLEMLEKGEKPECAKCKTKQTCSKQMFIRKLPQVLCLHMKRF- 453

  Fly   790 ADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEG-GHYTAFCK 853
              ..|.|   |....:.||:..||:..::......|  |.||.|.::..|.|...| |||.||.|
Worm   454 --RDNGG---KNDAIIDFPMGQLDVTQFLTDDSDEA--PCTYSLQSIIVHIGYGCGSGHYIAFGK 511

  Fly   854 SANYGKWFKFDDQVVSALDSSNVVSSAAYILFYT 887
              ..|:||:|||.||..:|.::|....||:|.||
Worm   512 --RNGRWFQFDDTVVKGVDEAHVSKQKAYVLLYT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	107/356 (30%)
		Peptidase_C19R	564..887	CDD:239139	107/357 (30%)
usp-3	NP_493434.3	zf-UBP	53..111	CDD:366940
usp-3	NP_493434.3	UCH	229..542	CDD:366104	107/356 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14283
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950