Protein Alignment Usp8 and usp-50

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_507513.2
• Gene: usp-50 / 180175
• WormBaseID: WBGene00008441
• Length: 811
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 107/545 - (19%)
• Similarity: 167/545 - (30%)
• Gaps: 182/545 - (33%)

  Fly   202 MAAG---RSDGTVDLYDLEKRQLITQTPGAGGGGGAGAGGGGGGGGQPVR--------------- 248
            ||||   .:.|.|.:..|..|:::....|....||.....|..|..:.||
 Worm     1 MAAGVMVTATGAVVILYLLSRRIVWARNGEDDSGGELGKSGRSGRRRIVRRPAQAPATWLETIST 65

  Fly   249 -----CVTFDES-GKCLLVGTAAGITVV----GWEPDREYDRIDSNWCQLGDMKIAG--TKLL-- 299
                 ..|:.|: ||..:...|.||..:    |..|.... ...||..:|...:|..  |:||
 Worm    66 LSETLRFTYSETLGKWPIADLAFGINYLMRRQGNFPTASV-YAGSNCIELKGPEIIMDLTELLRF 129

  Fly   300 -----------FGTY-EDASVTIHAVPLGQLRAFYNPQNPQ----PPTFT-HNQTSRKS---FSR 344
                       |..: |.|..|...|.|         |.|:    .|.|| ...|:.|.   ..|
 Worm   130 LTLCMLFSKKPFAVFLESAGYTHEDVLL---------QKPKAGIMQPAFTIIRDTNSKCILLLIR 185

  Fly   345 GSGKVRLSIGGGAGGGPSAGHSPDAGQDGELGSGNGGGMSPNLNIEMIDEEDATYAGGSAFEFDV 409
            |:..::.::....|......||          ..:.||:| ||.:
 Worm   186 GTHSIKDTLTAATGAVVPFHHS----------VLHDGGLS-NLVL-------------------- 219

  Fly   410 PAGHPKCSLEAMGNGGGGSTVAAGGVP--AVPTDMPAFPAGP-------GEGVGGPATVPLVNSH 465
              |:..|          |...||..:.  :||..:.|....|       |..:|| .|..|:.
 Worm   220 --GYAHC----------GMVAAARWIAKLSVPCLLKALDENPSFKVQIVGHSLGG-GTASLLT-- 269

  Fly   466 YLVREEMHMYNLNTLDYYPLP--KGHVPEPEK----------EDFPVNNAQPPDYAPKSATQPGT 518
            |::||:....:.....:.|..  ...:.|..|          :..|..:|...|......|....
 Worm   270 YILREQKEFASATCFTFAPAACMTWDLAESGKHFITTIINGSDLVPTFSASSVDDLRSEVTSSSW 334

  Fly   519 AG---------------YVNGGSAGGGGPAAGKVTSRVSASGR--ASASGGTD--QRRPGSIHGG 564
            :.               |.:..:.|...|:.....::|:.:|.  ...|.||.  .:|...:...
 Worm   335 SNDLRDQVEHTRVLSVVYRSATAIGSRLPSIASAKAKVAGAGAILRPVSSGTQVMLKRAQDVAQA 399

  Fly   565 VGHSR---SAGNLV---RRLATSKSTLELNKLP---------------LNETFAFKKPISRGSSP 608
            |..:|   |:.:.:   ||..:|:...::..:|               |.||.|..:   :|...
 Worm   400 VVQTRSTLSSWSCIGPRRRAISSQLNSKVTDMPEASAIMAERRSTEALLAETVAIDR---KGHKR 461

  Fly   609 IRHQHAHAPPYHGSGSSSSKIQRSE 633
            ..|          |.||||:..|.|
 Worm   462 TEH----------SSSSSSESDRDE 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	24/103 (23%)
		Smc	<361..>511	CDD:440809	30/170 (18%)
		Peptidase_C19R	564..887	CDD:239139	20/91 (22%)
usp-50	NP_507513.2	USP8_dimer	<28..115	CDD:462647	18/87 (21%)
		UCH	478..808	CDD:425685