DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and H34C03.2

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001293696.1	Gene:	H34C03.2 / 177437	WormBaseID:	WBGene00019259	Length:	980	Species:	Caenorhabditis elegans

Alignment Length:	955	Identity:	186/955 - (19%)
Similarity:	294/955 - (30%)	Gaps:	420/955 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 PRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWK---RQ 381
            |.|:....::..|.||.|........|::.:.:.:.::.| :...|:|:.....:.|.|.   :.
Worm     2 PTPEDVPMDENDAGRVAEGSQDESKTPSREVLKKLLNEVE-MAEMEENEMWYLISQKWWNSLIKA 65

  Fly   382 AAEG--------DGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKE 438
            ..:|        |....:|.:...|.:.|..::..||......|.:.|.|...:.:..:...|:.
Worm    66 VRDGFVDDVGPIDNSQISECRNGSFFLKQRLAEQVDYTPVPEILFKRLERFYHIDDDRRDYIQRR 130

  Fly   439 V------------------EATRNIESK-----------IRERQRLDEQHELERQERER------ 468
            |                  .:.||.:.|           :..|:|:..:..|...:..|
Worm   131 VVRKDGKLCIEVYPRIVHITSARNRDIKADLVLRPDDTMVSLRERVIGELSLSTTDNIRFYVMNG 195

  Fly   469 ----LLAIARETKKHY--------------------KSPTPS---GPPSPGRNLEDVHVVSDSLE 506
                |:..|:....::                    ||.||.   |..|...:.|      |.:|
Worm   196 ENYELIDTAQSIDSYFDTVQKVVVDVEEDGEFFIKGKSATPKSLFGTQSSSSDSE------DDVE 254

  Fly   507 SLLQLTGDPDP---------TIA--PNKAEIP------TFDRA---------------------- 532
            ::::|   |.|         |::  .:|..:|      :|..|
Worm   255 NVVRL---PKPNRHRQFSTSTVSSTSSKLLLPLWAVWLSFREAWWGFSQLWPDTIREAVAFLFGW 316

  Fly   533 --MKPQPRNVER-----TSQRVRDFSPVIG--QNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLT 588
              ::| |....|     .|......||..|  .....|..||.||||||:|.|..|||||.|.|.
Worm   317 WILRP-PSYSSRHGGNGISNSYNSPSPSTGVVTRTTPGACGLSNLGNTCFMASAFQCLSNMPPLR 380

  Fly   589 EYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQ 651
            ||.:::.|:|.|:..|.  |:|.:...|..|:|.:|:|.|..:..|..:.::||:...|.|..||
Worm   381 EYFLANTYQNDINEDNPLGTHGHLAMAVGELMKGMWSGDYASINPRKFKSIIGQFAPRFNGYSQQ 445

  Fly   652 DSHEFLTILMDWLHSDLQTLHVPRQREMISASE------------KAWLEFTKAKESMILHLFYG 704
            |:||.:..::|.||.||..:   :::..|..|:            |:|..:....:|:|:...:|
Worm   446 DAHELMAYVLDGLHEDLNRI---KKKPYIEDSDEDAKLPEAEYAAKSWEVYKMRNDSIIVDTLHG 507

  Fly   705 QMKSTVKCVACHKESATYESFSNLSLELPP----------------------------------- 734
            |:|||:.|..|.|.|..::.|..|||.|||
Worm   508 QLKSTLICPVCEKISIKFDPFGYLSLPLPPKEQIVKQTVIVMFLTRKWAKFSLGITDTTTVEEAE 572

  Fly   735 ----------------------------------------------------------------- 734

Worm   573 RLMLDKLQPEQQHHFVFFHVPSQYHDDITMMRPGDRVRMPGREVYVAEVEHDLQVKGTRLFVAYN 637

  Fly   735 ---------------------------------------------------NSN----------- 737
                                                               |||
Worm   638 RIKLVRSASLPMIYSLPTGYPLTRGFLNDHVFSTTKHFFINPKAVAELGGGNSNDDDSMSGSNSA 702

  Fly   738 ---------------------------------------------VCQ----------------- 740
                                                         |.|
Worm   703 DEREPYKLFVGPPGSTASLPIPPTDDPIPFPDENSHDIYSNFLQIVFQWKDLKIFNQYKGNELIE 767

  Fly   741 ------------LNQCMDMYFSGERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYA 790
                        |.:.:|.:.:.|::   ..|.||.||....|.|:|.:.|||.:|::|||||
Worm   768 REMTVSTRRKVLLQETLDWFTTKEQLGEQDSWYCPQCKKHERATKQLALWKLPEILILHLKRF-- 830

  Fly   791 DPSNSGSYMK----KQNY-LRFPLENLDMNPYIARA-ESRAVTPKTYQLYAVSNHYGTMEGGHYT 849
                  .|.|    |..: :..|:..||:...:|.. ..:|:    |.|.|||.|||::.|||||
Worm   831 ------QYTKWSREKLTWEVVIPVRGLDLTDKVANPNHEKAI----YDLIAVSRHYGSLSGGHYT 885

  Fly   850 AFCKSANYGKWFKFDDQVVSALDSSNVV--------SSAAYILFY 886
            |...:....|||.|:|      .|:|..        ||..|||.|
Worm   886 AIGYNDREQKWFDFND------SSANPTYPPAEPYESSDPYILVY 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	127/590 (22%)
		Peptidase_C19R	564..887	CDD:239139	128/590 (22%)
H34C03.2	NP_001293696.1	DUSP	51..135	CDD:197831	14/83 (17%)
		Peptidase_C19	356..>583	CDD:271592	68/229 (30%)
		Peptidase_C19	<777..925	CDD:271592	55/166 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940